Term
| Mutations that completely arrest maturation early in blood cell development give rise to.. |
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Definition
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Term
| Mutations that impair and slow blood cell maturation give rise to the |
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Definition
| myelodysplastic disorders (MDS) |
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Term
| Mutations that cause autonomous overprdxn of mature blood cells (FINISH) |
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Definition
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Term
| Leukemia classifications: |
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Definition
1. acute or chronic
2. myeloid or lymphoid |
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Term
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Definition
~5/100,000
Childhood 80% is ALL
Adulthood 80% is AML |
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Term
| Down Syndrom increases the risk of ALL and AML by |
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Definition
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Term
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Definition
-autosomal recessive
-low birth weight, growth, retardation etc..
-increased risk of AML or ALL by 10% |
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Term
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Definition
| germ line p53 mutation, auto dom, familial clustering of certain cancers: ALL, breast etc... |
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Term
| Identical Twins have a higher risk of developing AML or ALL |
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Definition
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Term
| Exposure to radiation or industrial chemicals decrease chances of AML or ALL |
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Definition
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Term
| Any time an MDS turns into an acute leukemia, prognosis |
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Definition
| is worse than if AML alone |
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Term
| Exposure to certain drugs: alkylating agents & topoisomerase inhibitors |
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Definition
| increase chances of developing acute leukemias |
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Term
| Pre-xisting conditions that increase risk of AML or ALL |
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Definition
-MDS
-Myeloproliferative Disorders
-Paroxysmal Nocturnal Hemoglobinuria
*Leukemias arising from these is conditions are relatively resistant to Tx |
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Term
| Leukemia cells produce manifestations of the disease by infiltrating and replacing the BM and other organs, PRDXN of normal WBC and RBC and Platelets is progressively diminished, resulting in overwhelming infections, severe anemia and life threatening hemorrhage, INFEC (FIISHIN), slide 23 |
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Definition
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Term
| Clinical characteristics of acute leukemias |
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Definition
-anemia
-neutropenia
-thrombocytopenia
-no hepatosplenomegaly with acute, more with chronic |
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Term
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Definition
-morphology
-cytogenetics
-flow cytometry |
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Term
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Definition
M0-no dist features, 5%
M1-few granules, rare Auer Rods
M2-More granules, Occ Auer Rods
M3-Hyper granlary, freq Auer Rods,
(finish) |
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Term
| APL commonly causes what? |
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Definition
| DIC, due to Tissue Factor released from the blasts, and the fibrinolysis from unique plasminogen activators |
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