Term
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Definition
| 5HT 1B, 1D agonist: for migraine |
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Term
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Definition
| 5HT3 antagonist; anti-emetic |
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Term
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Definition
| 5HT4 partial agonist: chronic constipation |
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Definition
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Definition
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Term
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Definition
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Term
| St. John's Wort (contains hyperforin) |
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Definition
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Term
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Definition
| 5HT3 antagonist; anti-emetic |
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Term
| Type of serotonin receptor? Opens K+ channels, inhibits Ca2+ channel, decreases cAMP |
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Definition
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Term
| Type of serotonin receptor? Activate PLC--> IP3, DAG; increase [Ca]in, activate PKC, inactivate K+ channel |
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Definition
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Term
| Type of serotonin receptor? Cation channel; Na+, K+ |
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Definition
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Term
| Type of serotonin receptor? increases cAMP |
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Definition
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Term
Neurotransmitter that can be found:
-enterochromaffin cells in the gut, where it regulates intestinal movements
-platelets, where it helps to regulate hemostasis and blood clotting
-raphe nuclei, neurons of which terminate in hypothalamus,
-limbic system,
-cerebellum
-pineal gland, where it is coverted to melatonin |
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Definition
| Serotonin (5-hydroxytryptamine) |
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Term
| Which serotonin receptor regulates: anti-emesis? |
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Definition
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Term
| Which serotonin receptor regulates: appetite? |
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Definition
| 5HT2c on dopaminergic nerve endings |
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Term
| Which serotonin receptor regulates:behavior? |
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Definition
| balance of 5HT1 and 5HT2 receptors; increased 5HT1 receptors associated w decreased aggression |
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Term
| Which serotonin receptor regulates:cellular and bone growth? |
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Definition
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Term
| Which serotonin receptor regulates: chemoreceptor trigger zone? |
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Definition
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Term
| Which serotonin receptor regulates: chronotropy (+) and inotropy (+)? |
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Definition
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Term
| Which serotonin receptor regulates: endothelial NO synthase activation and vasodilatation? |
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Definition
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Term
| Which serotonin receptor regulates: GI motility? |
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Definition
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Term
| Which serotonin receptor regulates: Insulin release from pancreas? |
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Definition
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Term
| Which serotonin receptor regulates: Platelet aggregation? |
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Definition
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Term
| Which serotonin receptor regulates: Vasoconstriction? |
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Definition
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Term
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Definition
| 5HT1A agonist; for anxiety |
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Term
| Contraindications for 5HT1D,1B agonists? |
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Definition
| Coronary artery disease, angina (because coronary arteries also express these receptors, hence can cause vasoconstriction). Usu used for acute migraine |
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Term
| Triptans (Sumatriptan, almotriptan, eletriptan, naratriptan, frovatriptan, zolmitriptan) |
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Definition
| Acute migraine. Contraindications: coronary artery disease, angina |
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Term
| Serotonin agonists or antagonists? Trazodone, Ketanserin, ritanserin, clozapine, risperidone, olanzapine, trazodone, ondansetron, granisetron, tropisetron, tegaserod |
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Definition
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Term
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Definition
| For depression, priapism; 5HT1, 5HT2A antagonist |
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Term
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Definition
| 5HT2 antagonist: vasodilation, bronchodilation |
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Term
| Clozapine, risperidone, olanzapine |
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Definition
| 5HT2 antagonist; treat psychosis |
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Term
| Ondansetron, granisetron, tropisetron |
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Definition
| 5HT3 antagonist: for nausea, vomiting assoicated w surgery and chemotherapy |
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Term
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Definition
| 5HT4 agonist; irritable bowel syndrome, constipation |
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Term
| Citalopram, Escitalopram, Fluoxetine, Fluxoamine, Paroxetine, Sertraline |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| SNRIs (TCAs) for depression |
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Term
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Definition
| SNRIs (TCAs) for depression |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Hyperforin (St John's Wort) |
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Definition
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Term
| interaction following the concurrent administration of an MAOI and SSRI or TCA |
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Definition
Serotonin syndrome: tachycardia, hypertension, hyperactivity, hyperpyrexia, convulsions, and coma;
especially problematic with fluoxetine because of its long half-life |
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Term
What risk has been associated w the following 3 groups of serotonergic drugs?
Serotonergic vasoconstrictive anti-migraine drugs (ergotamine and methysergide)
Serotonergic appetite suppressant drugs (fenfluramine, chlorphentermine, and aminorex)
Anti-parkinsonian dopaminergic agonists, which also stimulate serotonergic 5-HT2B receptors (pergolide and cabergoline) |
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Definition
| Risk of retroperitoneal and cardiac valve fibrosis |
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