Term
| antibodies that react with an individual's own endogenous antigenic determinants |
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Definition
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Term
| two genetic factors influencing autoimmune disease |
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Definition
| familial tendencies and HLA associations |
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Term
| What kind of antibodies are present in autoimmune hemolytic anemia? |
|
Definition
| erythrocyte antibodies; antibodies directed against red cells |
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Term
| what test is used to detect autoimmune hemolytic anemia? |
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Definition
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Term
| in idiopathic thrombocytopenic purpura (ITP), what are the antibodies directed against? |
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Definition
| antibodies directed against platelets causing shortened platelet survival |
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Term
| What antibodies are present in Hashimoto's disease? |
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Definition
| cytotoxic antibodies directed against thyroglobulin |
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Term
| what autoimmune disease causes painless enlargement of the thyroid and is 10 to 15 times more frequent in females? |
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Definition
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Term
| What autoimmune disease causes hypothyroidism? |
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Definition
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Term
| In Graves' disease, what is the antibody directed against? |
|
Definition
| cell surface thyroid stimulating hormone (TSH) receptors |
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Term
| what autoimmune diseases are most common in females aged 20-40 years? |
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Definition
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Term
| what autoimmune disease causes hyperthyroidism? |
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Definition
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Term
| What autoimmune disease causes elevated T3, T4, and decreased TSH? |
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Definition
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Term
| what antibody is present in pernicious anemia? |
|
Definition
| antibdoy directed against intrinsic factor (IF) |
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Term
| what autoimmune disease interferes with the absorption of B12? |
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Definition
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Term
| The intrinsic factor antibodies in pernicious anemia are produced by what cells? |
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Definition
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Term
| In infertility, antibodies are produced against what? |
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Definition
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|
Term
| what autoimmune disease causes aggregation of sperm? |
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Definition
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Term
| In Goodpasture's syndrome, what are the autoantibodies directed against? |
|
Definition
| Glomerular basement membrane |
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|
Term
| what autoimmune disease is associated with glomerulonephritis, complement-fixing antibodies, and lung hemorrhage? |
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Definition
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Term
| In Myasthenia gravis, what are the autoantibodies directed against? |
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Definition
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|
Term
| what autoimmune disease is twice as common in females? |
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Definition
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Term
| what autoimmune disease causes abnormal neuromuscular transmission, muscle weakness and fatigability? |
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Definition
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|
Term
| what autoimmune disease has an HLA B8 association? |
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Definition
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|
Term
| what autoimmune disease has complexes of nuclear antigens, immunoglobulins and complement? |
|
Definition
| Systemic lupus erythematosus |
|
|
Term
| what autoimmune disease has immune complexes in circulation and in kidneys? |
|
Definition
| systemic lupus erythematosus |
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|
Term
| what autoimmune disease is associated with decreased serum complement components C3 and C4? |
|
Definition
| Systemic lupus erythematosus |
|
|
Term
| what autoimmune disease is associated with increased sedimentation rate, increased serum gammaglobulins, positive ANA, abnormal urinalysis, LE cells? |
|
Definition
| systemic lupus erythematosus |
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|
Term
| what autoimmune disease is associated with immunological hyperreactivity resulting in increase cellularity of synovial membranes? |
|
Definition
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|
Term
| what autoimmune disease is associated with an IgM antibody against IgG? |
|
Definition
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|
Term
| what autoimmune disease causes joint erosion? |
|
Definition
|
|
Term
| what three types of tests can be used to detect autoantibodies? |
|
Definition
| immunofluorescence, agglutination tests, and radioimmunoassay (RIA) |
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Term
| Three techniques used in treatment of autoimmune disorders |
|
Definition
| Metabolic control or replacement therapy, anti-inflammatorydrugs, and immunosuppressive drugs |
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|
Term
| cyclosporin A, azathioprine, cyclophosphamide and methotrexate are all types of what? |
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Definition
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|
Term
| steroids, salicylates, ibuprophen and gold salts are all types of what? |
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Definition
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|
Term
| vitamin B12 is used to treat what autoimmune disease? |
|
Definition
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|
Term
| insulin is used to treat what autoimmune disease? |
|
Definition
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|
Term
| anti-thyroid drugs are used to treat what autoimmune disease? |
|
Definition
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|
Term
| Thymectomy is used to treat what autoimmune disease? |
|
Definition
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