Term
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Definition
Fast-acting Na channel blocker used in seizures. Hydrontion
#1 tonic clonic and status epi.
HEPATIC CYP NONLINEAR ELIM BOUND TO PLASMA PROTEINS
CAUSES MOST GINGIVAL OVERGROWTH
from increasing fibroblast prolif.
1. nyastagmus/ataxia
2. hypersentivity (toxic epi)
3. teratogen
4. decreased bone mineral density |
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Term
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Definition
Fast-acting Na channel blocker used in seizures, neuro pain, bipolar
Cyp450 that undergoes AUTOINDUCTION
1. ataxia
2. agranulocytosis
3. hypersensitivity
4. teratogen
5. decreases bone mineral density (through catabolism D3)
-easier to dose than phenytoin. |
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Term
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Definition
Fast-acting Na channel blocker + extra for seizures as adjudicative therapy
undergoes hepatic glucuronidation therefore less interactions
pheny/carbaz = increase elim
valproic = decreased elim
1. cns = dizzy/ASEPTIC MENINGITIS
2. TERATOGEN (lower)
3. HYPERSENSITIVTY RASH <16 |
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Term
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Definition
Fast-acting Na channel blocker + T-type Ca used in seizures. --> COMPLICATED
Na channel blocker, gaba increaser, Ca2 blocker
Phenytoin decreases serum levels due to increased hepatic glucuronidation
THIS INCREASED AMOUNT FREE PHENTOIN VIA COMPITION ALBUMIN
1. Teratogen
2. HEPATOXIC/PANCREATITIS
3. Nausea/vomiting |
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Term
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Definition
T-type Ca2+ channel blocker used in ABSENT SEIZURES
CYP450 W/O ENZYME INDUCTION
GI DISTRESS
BONE MARROW DEPRESSION |
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Term
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Definition
Presynaptic Ca2+ channel (alpha2-delta subunit) modulators
MORE OFTEN NEUROPATHIC PAIN SUCH AS HERPETIC NEURALGIA
RENALLY ELIMINATED THEREFORE NO INTERACTIONS
gabapentin has limited oral bioavailability
1. Weight Gain
2. CNS euphoria/dizzyness |
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Term
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Definition
Presynaptic Ca2+ channel (alpha2-delta subunit) modulators
MORE OFTEN NEUROPATHIC PAIN SUCH AS HERPETIC NEURALGIA
RENALLY ELIMINATED THEREFORE NO INTERACTIONS
gabapentin has limited oral bioavailability
1. Weight Gain
2. CNS euphoria/dizzyness |
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Term
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Definition
synaptic transmission modulator via PRESYNAPTIC VESICLE PROTEIN for adjudicative therapy
RENALLY ELIMINATED
1. fatique/mood swings |
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Term
| Seizure types and treatment |
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Definition
1. Status Epilepticus: phenytoin
2. generalized: phenytoin, carbamazepine, lamotrigine
3. absent: ethosuximide, valproic acid
4. partial: cabamazepine, valproic acid, phenytoin
5. partial adjunctive: lamotrigine |
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Term
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Definition
Paroxysmal depolarizing shifts
The PDS is a slow, long-lasting local depolarization that moves
the neuron close to the threshold for Na+ channel activation.
Caused by T-type Ca2+ channels in absense seizures |
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Definition
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