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Sedative/Anxiolytic
Pharmacology
30
Medical
Professional
01/21/2012

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Cards

Term
Three barbiturates
Definition
phenobarbital pentbarbital and thiopental
Term
half life of Barbs from longest to shortest
Definition
phenobarbital>pento>thiopental
Term
Barb activity in CNS
Definition
any state of sedation

decrease in % of REM sleep

NO analgesia
Term
what is tolerance to barbs due to
Definition
induction of P-450
Term
what are barbs contra'd in
Definition
patients w/porphyria
Term
Benzo prototype
Definition
diazepem
Term
Activity of benzos
Definition
sedative
anxiolytic
anticonvulsant
muscle relaxant
amnesia
Term
advantages of benzos
Definition
do NOT induce p450 and lower withdrawal syndromes
Term
mech of action for benzo
Definition
increase amount of Cl- by GABA a receptor
Term
what alpha receptors are known for sedative effects
Definition
alpha 1 and 3
Term
clinical use of benzo
Definition
emotional and somatic symptoms
low levels of depression
anxiety w/organic dz
muscle relaxants
Term
adverse rxn of benzo
Definition
teratogenic effect in first trimester
Term
Half life of benzo from longest to shortest
Definition
diazepam>alprazolam>chlordiazepoxide
Term
Benzo that is well absorbed IM
Definition
Lorazepem
Term
use of benzos in sleep disorders
Definition
sleep disorders assoc w/depression
Term
benzo antag
Definition
flmazenil
Term
GABA a agonists
Definition
zolpidem, zaleplon, and eszopiclone
Term
GABA ag that causes decrease in REM sleep
Definition
eszoplicone
Term
GABA ag with the shortest half life
Definition
Zaleplon
Term
what is zaleplon metabolized by?
Definition
aldehyde oxidase and CYP3A4
Term
what is eszopiclone metabolized by
Definition
CYP3A4 and CYP2E1
Term
adverse effect of eszopiclone
Definition
memory impairment
Term
This GABA ag causes dizziness, diarrhea and GI irritation
Definition
zolpidem
Term
residual daytime sedation occurs w/ what Benzo
Definition
zolpidem and eszopiclone
Term
comb of zolpidem w/SSRI
Definition
visual hallucinations
Term
Buspirone mech of action
Definition
5-HT
Term
clincial use of bisiprone
Definition
antianxiety ONLY
LONG LATENCY 4-6 weeks
Term
drug interaction of buspirone
Definition
displace digoxin
Term
Anti histamine
Definition
Hydroxyzine
Term
greater ataxia and memory disturbance: benzo or bus
Definition
Benzo
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