Term
Risks of Getting Schizophrenia |
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Definition
Identical Twins - 48% Fraternal Twins - 17% Children - 13% Siblings - 9% Parents/Half Siblings - 6% Grandchildren - 5% Nephews/Nieces - 4% Uncles/Aunts/First Cousins - 2% General Population - 1% |
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Term
Schizophrenia Demographics |
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Definition
Approximately - 2.4 Million or 1.1% of population Men and women equally Men appears in late teen/early twenties Women appears twenties/early thirties Women |
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Term
Dopamine hypothesis of schizophrenia |
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Definition
Model attributing symptoms of schizophrenia (like psychoses) to a disturbed and hyperactive dopaminergic signal transduction. |
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Term
Schizophrenia and the Brain |
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Definition
Enlarged Ventricles Experience Destruction of Cortical Gray Matter Over Time Decreased Metabolic Activity in the Prefrontal Brain Area |
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Term
Three Phases of Schizophrenia |
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Definition
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Term
Positive Symptoms of Schizophrenia |
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Definition
Hallucinations, Delusions, Bizarre behavior, disorganized speech |
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Term
Negative Symptoms of Schizophrenia |
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Definition
Affective Flattening, alogia (inability to speak), apathy, anhedonia (inability to experience pleasure), inattentiveness, anergia (lack of energy), avolition (lack of drive), ambivalence, social withdrawal. lack of self care, sleep disturbance |
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Term
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Definition
Auditory, Visual, Olfactory, Tactile (contact), Gustatory |
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Term
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Definition
Delusions of Reference Delusions of Persecution Thought Broadcasting Delusions of Mind Reading Thought withdrawal Thought insertion Delusions of Guilt Delusions of Control Somatic Delusions |
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Term
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Definition
Inappropriate affect, Stereotypies, Self-dialoging, Gesturing, Bizarre grooming |
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Term
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Definition
Loosening of associations Tangentiality Incoherence Confabulation Clang Associations Word Salad Neologisms |
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Term
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Definition
LACK OF DRIVE: Restriction of the initiation of goal directed behavior. The person may sit for a long period of time and show little interest in participating in work, self care or social activities. |
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Term
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Definition
INABILITY TO SPEAK: Poverty of speech, restrictions in fluency and productivity of thoughts and speech. Characterized by brief, laconic, empty replies |
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Term
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Definition
Restrictions in the range and intensity of emotional expression. Face appears immobile and unresponsive, with poor eye contact and reduced body language |
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Term
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Definition
Inability to experience pleasure |
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Term
Other Symptoms of Schizophrenia |
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Definition
Inability to perform abstract thinking (use of proverbs/humor) versus concrete thinking Decreased awareness of environment Substance Abuse |
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Term
Criteria A-C of Schizophrenia |
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Definition
A. Two or more for at least a month - Delusions - Hallucinations - Disorganized Speech - Grossly disorganized or catatonic behavior - Negative Symptoms B. Social/Occupational Dysfunction C. Duration: Six months signs of disturbance which must include one month of active symptoms |
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Term
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Definition
Paranoid Disorganized Catatonic Undifferentiated Residual |
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Term
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Definition
Auditory Hallucinations Preoccupation with delusions that are usually persecutory nature May appear hostile or angry No Symptoms of: flat or inappropriate speech or behavior, catatonic behavior |
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Term
Disorganized Schizophrenia |
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Definition
Disorganized Speech Disorganized behavior Inappropriate or flat affect |
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Term
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Definition
Motoric Immobility a.e.b. catalepsy (including waxy flexibility) or stupor Excessive motor acticity ( that is apparently purposeless and not influenced by external stimuli) |
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Term
Schizophrenia, Undifferentiated |
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Definition
Following Symptoms of Criteria A are present - Delusions - Hallucinations |
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Term
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Definition
Absence of prominent delusions, hallucinations, disorganized speech and grossly disorganized or caratonic behavior Continuing evidence of the disturbance as indicated by presense of negative symptoms or two or more symptoms in Criteria A, example odd beliefs, unusual perceptual experiences. |
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Term
Co-morbidity of schizophrenia and substance use ot abuse |
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Definition
Alcohol abuse 30-50% Cannabis 15-25% Cocaine 5-10% Nicotine 50-90% |
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Term
Early Forms of Treatment for Schizophrenia |
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Definition
Institutionalization Psycho-surgery ECT Insulin Coma Theray Cold Packs Cathartics |
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Term
Treatment Considerations for Schizophrenia |
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Definition
Establish and maintain rapport Assure safety Obtain a thorough psychiatric and physical assessment Monitor and treat symptoms and side effects Involve family and/or care givers |
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Term
Anti-psychotic Medications |
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Definition
Conventional-First generation-Dopamine Antagonists Atypical-Second generation-Serotonin-Dopamine Antagonists |
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Term
Conventional First Generation Medications In order of potency (Increased EPS (Extrapyramidal symptoms), risk NMS - Neuroleptic malignant syndrome) Less potent: More sedating, anticholinergic, orthostatic hypotension, increased risk for seizure |
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Definition
Pim-o-zide (Orap) Flu-phen-a-zine (prolixin) Hal-o-peri-dol (haldol) Thiothixene (Navane) Tri-flu-o-perazine (Stelazine) Per-phen-azine (Trilafon) Lox-apine (loxitane) Proch-lor-perazine (compazine) Chlor-prom-azine (Thorazine) 1st Drug (1955) Thiorid-azine (mellaril) |
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Term
Convential (1st Generation) Antipsychotics |
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Definition
Treat positive symptoms but not negative Major Side effects: EPS, Anticholinergic, NMS, Photosensitivity, Cardiac Haldol, Prolixin) Decanoate are long acting injectables |
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Term
Extra-Pyramidal Side Effects (EPS) |
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Definition
Parkinsonism (tremor, bradykinesia, rigidity) Akathesia Dystonia Tardive dyskinesia |
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Term
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Definition
Resting Rhythmic Course Affects the limbs, head, mouth, tongue |
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Term
EPS: Parkinsonian Bradykinsia |
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Definition
- Impaired body movement, difficulty beginning or maintaining a body motion, inability to perform repetitive, simultaneous or sequential body movements, rigidity - Immobile, expressionless or masked face - Loss of arm swinging when walking, shuffling gait - Decreased fine motor control |
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Term
EPS: Parkinsonian Rigidity |
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Definition
- Cogwheel rigidity
- Leadpipe rigidity |
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Term
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Definition
- Subjective feelings of inner restlessness, urge to move, irritability, panic, impatience, tension, dysphoria - Objective components of crossing and uncrossing legs while sitting, restless legs, lifting feet as if marching on the spot |
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Term
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Definition
- Oculogyric crisis: upwards and outwards deviation of the eyes - Torticollis: Head held turned to one side - Opisthotonic crisis - Buccolingual Crisis: protrusion of tongue, forced jaw opening, facial grimacing, difficulty speaking - Laryngospasm |
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Term
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Definition
All of the skeletal muscles of the body are contracted simultaneously, and the body assumes a position dictated by the strongest muscle groups |
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Term
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Definition
- Involentary random muscle twitching of the mouth, tongue, lips, jaw as well as facial grimacing, movements of the arms, legs, fingers, neck, trunk, hips - Can be mild and reversible or severe and irreversible - Disappears during sleep - Caused by long term exposure to conventional antipsychotics |
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Term
Anticholinergic Side Effects |
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Definition
- Dry mouth, constipation, bowel obstruction - Urinary retention, decreased sex drive - Dilated pupils, blurred vision - Tachycardia, postural hypotension - Decreased bronchial secretions - Lightheadedness confusion, impaired concentration, attention deficit, delirium |
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Term
Neuroleptic Malignant Syndrome - Potentially Fatal (20-30%) |
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Definition
- Severe Muscular Rigidity and dystonia - Respiratory Problems - Extreme Hyperthermia - Tachycardia and hypertension - Confusion, delirium - Agitation and/or akinesia Duration is upto 2 weeks Men and younger more affected High Potency antipsychotics more likely agents Worse with depot forms of medications Treatment: ICU |
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Term
PhotoSensitivity in Conventional AntiPsychotics |
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Definition
Flu-phen-azine (prolixin) Thiothixene (Navane) Perphen-azine (Trilafon) Chlorprom-azine (Thorazine) Thioridazine (mellaril) |
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Term
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Definition
Prolongation of ventricular repolarization (prolonged QT interval) Torsades de pointes - is a polymorphic ventricular tachycardia Sudden Cardiac death - 2X as general population Dose dependent thioridazine and ziprasidone |
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Term
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Definition
Anticholinergic
Benztropine (Cogentin) - Antihistamine
Diphenhydramine (Benadryl)
Trihexyphenidyl (Artane)
Amantadine (Symmetrel) - Anuti-viral
Antihypertensive
Propanolol (Inderal) - reduces tremor |
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Term
Atypical Antipsychotic Medications (also known as Serotonin-Dopamine Antagonists) |
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Definition
Aripiprazole (Abilify) • Asenapine (Saphris) • Clozapine (Clozaril) • Iloperidone (Fanapt) • Lurasidone (Latuda) • Olanzapine (Zyprexa) • Paliperidone (Invega) • Quetiapine (Seroquel) • Risperidone (Risperdal) • Ziprasidone (Geodon) |
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Term
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Definition
• Injected IM • Like all IM medications, aspirate the syringe to ensure no blood is visible prior to injection to assure that you are not hitting a vein. • Risk of PDSS (postinjection delirium sedation syndrome) the patient must be observed for three hours after each injection. • Administered every 2 to 4 weeks. • Depot forms of antipsychotic medications include Haldol (1), Prolixin(1), Zyprexa(2) and Risperdal(2) and some others |
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Term
FDA Recommendations for all patients taking atypical antipsychotic medications |
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Definition
Personal Family History Waist Circumference Blood Pressure Fasting Blood Glucose Fasting Lipid Profile Baseline and then every 4 weeks Body Mass Index WBC |
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Term
Patient Issues with Anti-psychotics |
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Definition
• Smoking: increases risk of tardive dyskinesia
• Alcohol: Additive effect with other CNS depressants
• Dehydration: Can result in decreased excretion through the kidneys
• Nutrition: Decreased protein can result in higher amounts of drug reaching the brain and CNS |
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Term
Non-Pharmacological Treatment Options |
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Definition
• Setting – Hospital – Community – Residential or long term care
• Psychosocial treatment – Psychosocial rehab – Psychoeducation – Individual or family interventions
• Medication – Conventional antipsychotics – Atypical antipsychotics |
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Term
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Definition
• Maintain safety
• Establish trusting relationship
• Promotion of self care
• Provide education, structure, consistency
• Assessment and treatment of co-morbidities
• Collaboration with other disciplines (OT, Expressive Therapists, Social Workers, Psychologists, Psychiatrists, health care administrators, insurance companies) |
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Term
Psychosocial Rehabilitation |
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Definition
• Based on the idea of schizophrenia as a severe, disabling, chronic and incurable illness
• Stresses integration of resources (including psychiatry, case management, PACT, ACT, psycho-education, socialization, vocational planning, medication compliance)
• Goal is to improve outcomes and reduce hospitalization by engaging the client’s strengths |
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Term
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Definition
• Family bears high level of burden.
• Social isolation is a frequent cause of relapse/exacerbation/rehospitalization.
• Negative symptoms militate against socialization and forming relationships.
• Relationship with a trusted provider improves outcomes, reduces need for hospitalization. |
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Term
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Definition
• Driving
• Friendship and family relationships
• Romantic relationships
• Work
• School
• Recreational drinking/drug use
• Medical issues
• Economic downward drift |
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Term
Desired Outcomes in Schizophrenia |
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Definition
• Remain free of harm, and demonstrate absence of violence toward others
• Be able to establish trusting, open relationship with therapist/nurse
• Report or experience no hallucinations
• Report or experience no delusional thought processes • Demonstrate increased socialization skills and decreased isolative behavior
• Demonstrate appropriate affect and improved thought processes
• Report the ability to experience pleasure and improved interest in activities
• Demonstrate improved ability to concentrate and complete tasks
• Demonstrate improved speech patterns and congruent communications
• Adhere to medication regimen as prescribed
• Demonstrate no EPS or adverse reactions to medication regimen
• Verbalize side effects and adverse reactions to report to prescriber
• Verbalize indication, dosage, route and schedule of medication regimen
• Demonstrate ability to complete ADLs with or without assistance
• Demonstrate effective coping patterns
• Utilize appropriate community resources |
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Term
Psychiatric De-escalation |
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Definition
• Use of restraints is typically last resort after de-escalation and prn medications have been attempted • Avoidance of mechanical and chemical restraints begins hours before a crisis arises |
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Term
Nursing Assessment for Preventing Violence |
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Definition
– Checks person needs to be scanning environment
– Check in with patients frequently to nip violence in the bud
• “How are your thoughts today?”
• “How are the voices?”
• “What have you been thinking about lately?”
• “Are your medications helping?”
• “Any problems with side effects?”
• “How did the (fill in blank) go?” |
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Term
Nursing Intervention for Prevention of Violence |
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Definition
– Be friendly and approachable and spend time on the unit and encourage that with your staff
– Feed a psychosis
– Determine if a room change is needed
– When beginning shift make a list of potentially violent or volatile patients and check to see what their medications (prn and standing) are
– Offer PRN medications to relieve distress, anxiety, impulsivity, anger
– Communicate with the patient’s doctor and the nursing administration about any concerns
– Alert other units and security if you think there may be a code call in the near future so they’ll be prepared |
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Term
Inpatient Use of Mechanical and Chemical Restraints |
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Definition
• Use of restraints is highly regulated by state departments of mental health
• Inpatient staff training: – De-escalation techniques – The safe use of mechanical and chemical restraints
• Institutional policy: – Safe staffing – Fast, effective communication among staff members – Continuous Quality Improvement issue – Involvement of the patient |
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Term
The Psychiatric Emergency |
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Definition
• Code team
• The code team leader (chosen at the time of the incident based on amount of experience, knowledge of patient)
• The show of force
• Putting hands on to subdue patient is point of no return
• Immobilize on floor, use a safety blanket for transport to QR, search pockets etc, apply restraints, administer medication, constant one to one arms length supervision, vital signs, monitor intake and output |
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Term
Role of the Charge Nurse Before, During, and After a Restraint |
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Definition
• Calls the code
• Delegates tasks such as restraint team leader
• Makes sure checks person stays on task
• Request cooperation of other patients (i.e.: go to rooms)
• Communicates with the patient’s inpatient psychiatrist and the nursing administration
• Responsible for making sure that doctor’s orders are received, carried out, transcribed
• Responsible for documentation of restraint
• Responsible for staffing the one to one
• Addresses the concerns of the other patients by discussing specific details about the restraint |
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Term
Managing Threatening Behavior in the Community |
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Definition
• At the outpatient and residential setting, dangerous or threatening behavior is managed by calling 911
• No doctor’s order required to call 911
• For adult populations, hospitals are the only sites where chemical and mechanical restraints are allowed |
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