Term
| Mechanism of Action (MOA) |
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Definition
| manner in which molecular targets are affected by the drug |
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Term
| Pharmacological (PCOL) effects |
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Definition
| The end points of the signal transduction events |
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Term
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Definition
| Cause the patient to stop taking the drug |
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Term
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Definition
| Medications and Health Conditions that Pose Considerable Risk |
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Term
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Definition
| Predictable reactions, some are merely bothersome |
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Term
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Definition
| Elicits a response from tissue |
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Term
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Definition
| the drug with the greatest pharmacological effects |
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Term
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Definition
| Effects are less than full agonist |
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Term
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Definition
| Causes an effect opposite to that of the agonist |
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Term
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Definition
| Prevention of activity of an agonist |
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Term
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Definition
| Binds at the same site on the receptor of agonist (overcome by giving more agonist) |
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Term
| Non-competitive Antagonist |
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Definition
| Binds at a different site than the agonist (never overcome by giving more agonist) |
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Term
| Un-competitive Antagonist |
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Definition
| Can bind at a different site than the agonist even when the agonist is bound |
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Term
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Definition
| tendency to bind receptors |
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Term
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Definition
| the ability to initiate a response |
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Term
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Definition
| capacity of a single drug-receptor complex to evoke a response |
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Term
| Allosteric Model of Drug Action |
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Definition
| Receptors exists in more than one configuration |
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Term
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Definition
| phenomenon of drug metabolism whereby the concentration of drug is greatly reduced before it reaches the systemic circulation |
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Term
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Definition
| fraction of unchanged drug that reaches the systemic circulation following administration by any route |
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Term
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Definition
| Time required for the plasma concentration of a drug to be reduced by 50% |
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Term
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Definition
| Transfer of drug from its site of administration to the blood |
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Term
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Definition
| Transfer of drug from blood to tissues; process by which a drug reversibly leaves the blood and enters the extracellular fluid or cells |
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Term
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Definition
| Enzymatic conversion of drugs to more polar compounds |
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Term
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Definition
| Removal of drugs from the body |
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Term
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Definition
| a process by which a drug induces more enzymes to be produced by the liver, other drugs will be metabolized faster |
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Term
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Definition
| when an enzyme is unavailable for metabolism of one drug because a second drug is being metabolized at the same time (First drug will be metabolized slower) |
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Term
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Definition
| the range of plasma drug concentrations with a high probability of therapeutic success |
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Term
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Definition
| Combination results in an effect of one that is greater than expected |
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Term
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Definition
| Additive effects of 2 drugs that share the same pharmacological effects |
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Term
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Definition
| Combination results in pharmacological effects that are greater than the maximum effects of either given alone |
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