Term
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Definition
| transfer of drug from its site of administration to the blood |
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Term
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Definition
| transfer of drug from blood to tissues; process by which a drug reversibly leaves the blood and enters the extracellular fluid or cells |
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Term
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Definition
| enzymatic conversion of drugs to more polar compounds |
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Term
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Definition
| removal of drugs from the body |
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Term
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Definition
| indicator of how drugs are dispersed among the body compartments |
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Term
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Definition
| time required for the plasma concentration of a drug to be reduced by 50% |
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Term
| 1st Pass Effect/Metabolism |
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Definition
| Orally this occurs from mouth to portal vein to liver. Metabolism occurs in liver. Metabolized drug excreted into bile is reabsorbed into the GI tract. |
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Term
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Definition
| fraction of unchanged drug that reaches the systemic circulation following administration by any route |
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Term
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Definition
| a process by which a drug induces more enzymes to be produced by the liver, other drugs will be metabolized faster |
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Term
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Definition
| when an enzyme is unavailable for metabolism of one drug because a second drug is being metabolized at the same time (first drug will be metabolized slower) |
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