Term
CYP family 1A2
3 inducers?
6 inhibitors? |
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Definition
inducers: Barbiturates(induces all CYP families except CD6)
Rifampin (induces all CYP families)
Omeprazole (only induces here)
inhibitors:Cimetidine (inhibits all CYP families)
Amiodarone (inhibits all CYP families except 2C19)
Selective Serotonin Reuptake Inhibitors (inhibits all CYP families)
Fluoroquinolones(also inhibits 3A4)
Macrolides(also inhibits 3A4)
Grapefruit juice(also inhibits 3A4) |
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Term
CYP family 2C9
2 inducers?
4 inhibitors? |
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Definition
Inducers:
Barbiturates (induces all CYP families except 2D6)
Rifampin (induces all CYP families)
Inhibitors:
Cimetidine (inhibits all CYP families)
Amiodarone (inhibitos all CYP families except 2C19)
Selective Serotonin Reuptake inhibitors (inhibits all CYP families)
Metronidazole (also inhibits 3A4) |
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Term
CYP family 2C19
4 inducers?
3 inhibitors?
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Definition
inducers:
Barbiturates (induce all except 2D6)
Rifampin (induces all cyp families)
phenytoin (also induces 3A4)
Carbamazepine (also induces 3A4)
inhibitors:
Cimetidine (inhibits all cyp families)
Selective serotonin Reuptake inhibitors (inhibits all cyp families)
Omeprazole (only inhibits here) |
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Term
CYP family 2D6
1 inducer?
4 inhibitors?
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Definition
Inducer: Rifampin (induces all cyp families)
Inhibitors:
Cimetidine (inhibits all cyp families)
amiodarone (inhibits all cyp families except 2C19)
Selective serotonin reuptake inhibitors (inhibits all cyp families)
HIV protease inhibitors (also inhibits 3A4) |
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Term
CYP family 3A4
5 inducers?
8inhibitors?
(this isozyme is respnosible for metabolism of 50% of all drugs) |
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Definition
Inducers:
Barbiturates (induces all cyp families except 2D6)
Rifampin (induces all cyp families)
Phenytoin (also induces 2C19)
Carbamazepine (also induces 2C19)
Corticosteroids (only induce here)
Inhibitors:
Cimetidine (inhibits all cyp families)
Amiodarone (inhibits all cyp families except 2C19)
Selective serotonin reuptake inhibitors (inhibits all cyp families)
fluoroquinolones (also inhibit 1A2)
Macrolides (also inhibit 1A2)
Metronidazole (also inhibit 2C9)
Grapefruit juice (also inhibits 1A2)
HIV protease inhibitors (also inhibit 2D6) |
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Term
| What are 4 receptors for the Gs protein that effects adenylyl cyclase to increase cAMP? |
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Definition
1. Beta-1
2. Beta-2
3. D1
4. H2 |
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Term
| What are three receptors for the Gi protein that acts on adenylyl cyclase to decrease cAMP? |
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Definition
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Term
| What are three receptors for the Gq protein that acts on phospholipase C to increase IP/DAG? |
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Definition
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Term
| 2 drugs that will cause idosyncratic methemoglobinemia for which the genetic basis is either abnormal hemoglobins or NADH methemoglobin reductase deficiency |
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Definition
1. nitrites
2. sulfonamides |
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Term
| A drug that will cause idiosyncratic prolonged apnea with the genetic basis being plasma cholineseterase deficiency |
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Definition
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Term
| A drug that causes idiosyncratic neurotoxicity with the genetic basis being N-acetyltransferase deficiency |
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Definition
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Term
| 4 drugs that cause idiosyncratic hemolytic anemia with the genetic basis being glucose-6-phosphate dehydrogenase deficiency |
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Definition
1. primaquine
2. salicylates
3. some sulfnamides
4. quinolones
(idiosyncratic hemolytic anemia: Please Sing Songs Quietly) |
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Term
| 5 drugs that that cause idiosyncratic porphyrias (acute intermittent variegate) with the genetic basis being deficiency of enzyumes of the heme biosynthetic pathway |
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Definition
1. barbiturates
2. phenytoin
3. ethanol
4. griseofulvin
5. estrogens
(idiosyncratic porphyrias: Billions of People Eat Greasy Eggs) |
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Term
| Drugs that cause idiosyncratic malignant hyperthermia with the genetic mechanism being unknown but highly probable |
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Definition
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Term
| Drug that causes idiosyncratic aplastic anemia with the genetic basis being unknown but highly probable? |
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Definition
chloramphenicol
(idiosyncratic aplastic anemia caused by your fav. antibiotic) |
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