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S3.M3.Pharm7
General Anesthesia
16
Pharmacology
Professional
08/03/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
what is BALANCED ANESTHESIA?
Definition
mixing of several drugs in smaller amounts to achieve desired level of effects without the adverse effects of a single drug
Term
general effects of anesthesia on RESPIRATION and BODY TEMPERATURE
Definition
depressed respiration
hypothermia
Term
what is MAC?
Definition
MINIMAL ALVEOLAR CONCENTRATION needed to prevent movement in 50% of patients
**this is ADDITIVE
Term
IV anesthetics
Definition
-thiopental
-propofol
-ketamine
-etomidate
Term
thiopental
Definition
-fast acting
-lipophilic
-lowers CNS blood flow, BP, and respiration
-raises HR
Term
propofol
Definition
-most common IV anesthetic
-short acting
-lipophilic
-lowers CNS blood flow, BP, and respiration
***advantage is that it has LITTLE NAUSEATING EFFECT***
Term
etomidate
Definition
***CVS STABILITY- good for hypotensives
***inhibits adrenocortical stress (CORTISOL) response
Term
ketamine
Definition
not used often
Term
what are the INHALATIONAL ANESTHETICS? other facts?
Definition
-Halothane
-Isoflurane
-Enflurane
-Desflurane
-Sevoflurane
-Nitrous oxide
**low therapeutic index**
Term
what is PARTITION COEFFICIENT
Definition
RATIO of anesthetic concentration in two tissues AT THE SAME PARTIAL PRESSURE
(i.e. less soluble drugs means less needs to go into the blood to reach equal partial pressure)
Term
Halothane
Definition
-not used often
-low MAC, high partition coefficient
***can cause MALIGNANT HYPERTHERMIA*** due to excess Ca2+ release from sarc. reticulum
Term
Isoflurane
Definition
-pungent odor
***used in NEUROSURGERY*** because decreases cerebral vasodilation and O2 consumption-unlike all other INHALATIONAL ANESTHETICS in that way
Term
Enflurane
Definition
more side effects than ISOFLURANE
Term
Desflurane
Definition
very pungent
***CI in ASTHMATICS**
Term
Sevoflurane
Definition
-NOT pungent
**no TACHYCARDIA**
Term
Nitrous Oxide
Definition
-MAC>100
-used in DENTAL PROCEDURES
-causes nausea and vomitting
***causes expansion of air filled cavities***--> CI in patients with pneumothorax, or air in GI, etc.
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