Term
| Drugs used to treat GENERALIZED ABSENCE SEIZURES- |
|
Definition
-Ethosuxamide
-Lamotragine
-Valproate
*Clonazepam when ETHOSUXAMIDE doesn't work |
|
|
Term
| drugs used to treat SIMPLE PARTIAL or PARTIAL seizures |
|
Definition
-Valproate
-Carbamazapine
-Phenytoin |
|
|
Term
| Drugs used to treat GENERALIZED TONIC CLONIC SEIZURES |
|
Definition
-Valproate
-Carbamazapine
-Phenytoin |
|
|
Term
| drugs used to treat STATUS EPILEPTICUS |
|
Definition
-Diazepam
-Lorazepam
-Phenytoin
-Phenobarbital |
|
|
Term
|
Definition
-used in STATUS EPILEPTICUS, sometimes in simple partial and generalized T/C seizures
-INDUCES cyp450
-increases length of time GABA channel is open (increasing Cl-)
ADVERSE:
-CNS depressant-->sedating
-dependance liability |
|
|
Term
|
Definition
-absense seizures when ETHOSUX. won't work
-PANIC DISORDER, GAD, some myoclonic *VERY POTENT
-inhibits Ca2+ channels
-increases FREQUENCY of GABA channel opening
-METABOLIZED by cyp 450
ADVERSE:
-sedation
-mood
-ataxia |
|
|
Term
|
Definition
-increases FREQUENCY of GABA channel opening
-used in GEL FORM for acute seizures-->rectal admin.
-adjuvant for myoclonic, partial, general T/C seizures
ADVERSE:
-dependency & tolerance
-CNS depressant
-anterograde amnesia |
|
|
Term
|
Definition
-partial seizures-->first line
-General T/C seizures-->first line
**may EXACERBATE absence or myoclonic seizures
-inhibits voltage gated SODIUM CHANNELS
-must start slowly and increase slowly
-METABOLISED by cyp450 3A4
-rash--> steven johnson (rare)
-teratogen, but BEST OPTION FOR PREGNANT |
|
|
Term
|
Definition
-idiopathic generalized epilepsies
-broad range of uses, but MANY SIDE EFFECTS keep it from being used more
-volt gated NA channels, Ca2+ block, GABA increase all mechanisms
-INHIBITS by cyp 450
-C/I in pregnancy |
|
|
Term
|
Definition
-ABSENCE SEIZURES-->first line drug
-blocks conduction in ACTIVATED T type Ca2+ channels
-METABOLIZED by cyp 450 3A4 (inhibited by Valpo)
ADVERSE:
-rashes--> steven johnson syndrome--> rare |
|
|
Term
|
Definition
-partial, generalized T/C seizures
-slows Na+ channel rate of recovery from inactivation--> only affects channels opened frequently
-NO CNS DEPRESSION***
-INDUCER of cyp 450
ADVERSE:
**cosmetic changes-->acne, hirsutism, facial coarsening
rashes--> SJ syndrome-->rare |
|
|
Term
| what drug is used for TRIGEMINAL NEURALGIA |
|
Definition
|
|
Term
| what drug is used for INFANTILE SEIZURES? |
|
Definition
|
|
Term
| what drugs are CI in patients with a history of PORPHYRIA? |
|
Definition
Phenytoin
Valproate
Carbamazepine |
|
|
Term
| drugs used for MYOCLONIC SEIZURES |
|
Definition
|
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