Term
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Definition
-Toxic to all dividing cells
-antiarthritic, immunosuppressive
-stops cells in the S phase (dividing cells only)
-used in graft rejection, autoimmune diseases, to treat type IV HS
-MERCAPTOPURINE is the active form |
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Term
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Definition
-Toxic to LYMPHOCYTES
-ANTIBODY made in horses against human lymphocyte preparations (T cells)
-used as a prophylaxis and treatment of graft rejection and aplastic anemia
-ALG binds T lymphocytes and stops cellular immunity NOT antibody formation |
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Term
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Definition
-Toxic to LYMPHOCYTES
-polyclonal human immunoglobulin (mostly IgG)
-no specific target-->used for passive immunity |
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Term
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Definition
-Toxic to LYMPHOCYTES
-technique for PREVENTING HEMOLYTIC DISEASE of the newborn (given to RHESUS - MOTHERS) |
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Term
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Definition
-Toxic to LYMPHOCYTES
-monoclonal ANTIBODY to CD3 surface molecules of thymocytes and mature(primed ) T-cells
-Causes “cytokine release syndrome” |
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Term
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Definition
-Toxic to LYMPHOCYTES
-enzyme |
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Term
| Steroids (glucocorticoids) |
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Definition
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Term
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Definition
Toxic to a sub population of immune cells-->revolutionized organ transplants
-similar to TACROLIMUS
-prevent graft rejection, treats GVHD, severe psoriasis
-very LIPOPHYLIC
-acts on CD4 helper T CELLS but must work before it becomes activated
-very NEPHROTOXIC |
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Term
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Definition
-Toxic to a sub population of immune cells-->also known as FK506
-similar to CYCLOSPORINE
-blocks CALCINURIN COMPLEX and inhibits it from phosphorylating NFAT (prevents graft rejection)
***if treatment with TACROLIMUS doesn't work, can switch to CYCLOSPORINE because receptors are different although mechanism is the same |
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Term
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Definition
-Toxic to a sub population of immune cells
-same uses as CYCLOSPORINE, however also used for STENT therapy for stenosed arteries
-like TACROLIMUS, also binds FK BP, but does NOT block CALCIURIN, instead blocks MAMMALIAN KINASE, mTOR*, which is a key enzyme in the in cell cycle progression-G1, S phase |
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Term
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Definition
-Toxic to a sub population of immune cells
-PRODRUG
-PROPHYLAXIS of transplant rejection
-inhibits INOSINE MONOPHOSPHATE DH, an important enzyme in the de novo guanine nucleotide synthetic pathway
-selectively inhibits T and B cells |
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Term
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Definition
-target INFLAMMATORY CYTOKINES or their receptors
-TNF alpha receptor |
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Term
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Definition
-target INFLAMMATORY CYTOKINES or their receptors
-monoclonal TNF alpha antibody
-can cause hypersensitivity |
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Term
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Definition
| -target INFLAMMATORY CYTOKINES or their receptors |
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Term
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Definition
-anti PARASITIC drug
-enhances T cell response
-adjunctive therapy with 5 FLUOROURICIL and LEUCOVORIN |
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Term
| Bacillus Calmette- Guerin (BCG) |
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Definition
-non specific immunotherapy
-Intravesica l therapy of BLADDER CANCER |
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Definition
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Term
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Definition
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Term
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Definition
-Colony –stimulating factor
-Granulocyte colony - stimulating factor --> used to promote NEUTROPHILS in cases of neutropenia
-Promotes myeloid recovery in patients given high dose chemotherapy |
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Term
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Definition
-Colony –stimulating factor
-stimulates both GRANULOCYTIC and MACROPHAGE progenitor cells and the mature cells
-Promotes MYELOID RECOVERY in patients given high dose chemotherapy |
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Term
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Definition
-Colony –stimulating factor (human growth factor)
-stimulating committed erythroid precursors, resulting in erythropoesis
-therapy in conjunction with adequate iron intake, and with ANEMIA therapy |
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Term
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Definition
-Colony –stimulating factor
-used to treat the ANEMIA, NEUTROPENIA and THROMBOCYTOPENIA associated with high –dose chemotherapy |
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