Term
|
Definition
-connective tissue disorder
-AD inheritance
-Fibrillin-1 gene mutt'n (most common) |
|
|
Term
|
Definition
-Ab's to PLT antigens (IIb/IIIa, commonly) --> increased PLT dstrct'n
-chr autoimmune disorder
-Dx of exlusion (other sources of thrombocytopenia; ie, defective megakaryopoiesis would be accompanied by pancytopenia)
- |
|
|
Term
|
Definition
-surface protein, tuberculin (outer surf. protein), & mycolic acid
-"TST" = "PPD", stim's cell-med'd immunity
-gnrt's delayed-type hypersensitivity
-cell wall peptidoglycan thinner than other bact
-M. tuberculosis related to G+ orgs |
|
|
Term
|
Definition
-rapid onset!
-spongiform encephalopathy with axonal degeneration, neuronal loss, gliosis
-accumulated PrP
-rapidly progressive dementia, memory loss, startle myoclonus/other involuntary mvmts
-EEG has high voltage slow waves
-6-12mos to death |
|
|
Term
|
Definition
-common in Parkinson's
-slowly progressions
-P.w/ visual hallucinations, delusions |
|
|
Term
|
Definition
1: AD (risks = age, family Hx, __)
2: vascular dementia (multi-infarct) (risks = HTN, DM, age, atherosclerosis, cardioembolic events) |
|
|
Term
|
Definition
-trinucleotide expansion (CAG repeats)
-AD
-Triad: chorea, behavioral change, dementia |
|
|
Term
|
Definition
-vertical gaze impairment
-dysarthria, disphagia, dementia, ataxia, extrapyramidal symptoms
-slow onset |
|
|
Term
|
Definition
-Nl ~ 40mmHg
-increased (~80) = arteriosclerosis, PDA
-dcrsd = aortic stenosis, mitral valve stenosis |
|
|
Term
|
Definition
-hi HR
-lo SV
-hi SVR
-lo CO |
|
|
Term
|
Definition
-hi HR
-lo SV
-hi SVR
-Nl CO!! |
|
|
Term
|
Definition
-hi HR
-hi SV
-hi CO
-lo SVR |
|
|
Term
|
Definition
-hi HR
-hi SV
-hi CO
-Nl SVR!! |
|
|
Term
| Familial hypercholesterolemia (FH)? |
|
Definition
-disorder from defective gene encoding LDL receptor
-AD
-gene dosing effect (homoZs > heteros) (worse)
- |
|
|
Term
| Class IB antiarrhythmics? |
|
Definition
-for V-tach
-block fast Na+ chnnls
-shorten AP duration
-incrs's excitt'n threshold
-dcrs's excitability of hypoxic heart M
-Lidocaine, mexiletine, tocainide
-modest suppression/sinus automaticity, AV node conduction |
|
|
Term
|
Definition
-ultra short-acting beta-1 adr blocker
-cardioselective
-Esmolol |
|
|
Term
| Class IV antiarrhythmics? |
|
Definition
-Diltiazem
-Verapamil
-Ca++ chnnl blockers
-dcrs & slow SA & AV node conduction |
|
|
Term
| Class 1A antiarrhythmics? |
|
Definition
-Disopyramide
-Procainamide
-dcrs myocard excitability, condct'n velocity, contractility, automaticity
-prolong ERP
-block vagal stim/AV node |
|
|
Term
| Common side effect of ALL Tx? |
|
Definition
| -uric acid kidney stones (incrs'd uric acid prod'n from incrs'd purine brkdn during chemo) |
|
|
Term
| Glossopharyngeal N, distal loc'n? |
|
Definition
-tonsillar fossa
-sensory & taste info from post 1/3 of tongue |
|
|
Term
| Spontaneous speech, fluent & nonsensical? |
|
Definition
-Wernicke's aphasia
-"word salad"
-"Right upper quadrantanopia," dmg to optic radiation fibers running through Wernicke's area to L visual cortex (from LGN) --> R vis. field defect
-patients unaware of disability
-Dmg to superior temporal gyrus (L, usually) |
|
|
Term
|
Definition
-Broca's aphasia
-"broken speech"
-Pts often aware of deficit --> frustrtd |
|
|
Term
| Typical (older) antipsychotics? |
|
Definition
-fluphenazine, halperidol
-high potency
-affinity for DR2s
-Extrapyramidal side effects: akathisia (motor restlessness), parkinsonism, tardive dyskinesia, torticollis (acute dystonia w/ involuntary contractions of neck and frequent displacement to one side) |
|
|
Term
| Atypical (newer) antispychotics? |
|
Definition
-Clozapine, olanzapine, risperidone, quetiapine
-fewer extrapyramidal side effects |
|
|
Term
|
Definition
-palmar: thumb + 2.5 fingers, radial side
-dorsal/volar: tips of thumb + first 2.5 fingers |
|
|
Term
|
Definition
-flexors of forearm
-thenar eminence
-radial lumbricals |
|
|
Term
|
Definition
-Compression of median nerve
-Sx's: pain, parasthesias, M weakness in supplied areas |
|
|
