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Ross S3 Multifaceted Model
Kelley
37
Microbiology
Professional
11/13/2009

Additional Microbiology Flashcards

 


 

Cards

Term
Common virulence factors for E.Coli
Definition
Endotoxin (LPS), Exotoxins for some, Adhesion molecules, capsule, Antibiotic resistance.
Term
The Polysaccharide core portion of LPS that is heat stable
Definition
O antigen
Term
Flagella on motile strains is called
Definition
H antigen
Term
The capsule is also called
Definition
The K antigen
Term
What does E.Coli ferment? What are the products of this fermentation?
Definition
Ferments glucose to ACID and GAS
Term
MacConkey grows ONLY...
Definition
Gram negative Rods. It contains Lactose, which also makes it a differential medium.
Term
The exogenous source via fecally contaminated food or water leads to what type of disease?
Definition
Intestinal disease
Term
If E.Coli is from an endogenous source it causes these types of diseases...
Definition
Extraintestinal diseases, UTIs and neonatal meningitis.
Term
What do differences in individual plasmids and integrated prophages lead to?
Definition
Differences in degree of virulence
Term
ETEC (Enterotoxigenic E.Coli) is the most common cause of...
Definition
Traveler's diarrhea.
Term
Define ETEC, EHEC, STEC, EPEC, EIEC, EAEC, DAEC.
Definition

Enterotoxigenic E. Coli (Traveler's)

Enterohemorrhagic E. Coli (Shiga-toxin)

Enteropathogenic E. Coli

Enteroinvasive E. Coli

Enteroaggregative E. Coli

Diffuse aggregative E. Coli

Term
What are the different types of pili on different species of E. Coli called?
Definition

CFA = colonization factor.

They provide for different types of virulence

Term
How does ST act?
Definition
Heat Stable toxin increases cGMP
Term
How does LT act?
Definition
Heat-labile toxin increases cAMP
Term
STa and LT are toxins associated with which strain of E.coli?
Definition
ETEC
Term
Describe the pathogenesis of the watery diarrhea associated with ETEC.
Definition
LT and STa cause prolonged hypersecretion of Cl- and water and inhibit reabsorption of Na+ leading to fluid in gut leading to watery diarrhea only
Term
Treatment of Traveler's Diarrhea
Definition
It is self limiting. Replace fluids with ORS (oral rehydration solution) which has Salt, Baking soda, Sugar, and Water. This is also known as Pedialite
Term
EHEC/STEC has what toxins?
Definition
Shiga-like or Vero toxin (SLT or VT)
Term
Your patient has watery, very bloody stool. What is the microbe responsible for this?
Definition
EHEC/STEC
Term
What part of the intestine does EHEC/STEC involved in?
Definition
Colon
Term
What are two unique virulence factors that EHEC/STEC posses?
Definition
Intimin and Entero-hemolysin, which causes BLOODY poo.
Term
O157:H7
Definition

This is the most common E.coli breakout.

It is in the EHEC family.

Term

Organisms efface (rub off) the microvilli and induce polymerization of actin filaments leads to form cuplike pedestal leads to intimin secretion allows intimate attachment to the surface of the host cells (A/E lesions) leads to secrete SLT (production controlled by a lysogenic phage) leads to inhibits protein synthesis by nicking the 60S ribosome.

 

What organism does this describe?

Definition

EHEC

O157:H7

Term
This bug carries the Locus of enterocyte effacement pathogenecity island that allows it to encode for the ability to induce attaching and effacing lesions on the host mucosa.
Definition
O157:H7
Term
Maconkey + Sorbitol is a differential for...
Definition
non-EHEC. O157:H7 is a non-sorbitol fermented so it will have clear colonies.
Term
Outbreaks of EHEC are usually associated with
Definition
Fast food hamburger joints (Jack in the Box)
Term
Hemolytic-uremic syndrome occurs in what populations and are associated with which strain?
Definition
HUS occurs in children and the elderly. It is associated with EHEC and leads to acute renal failure in children. This is seen as thrombotic microangiopathy and thrombocytopenia.
Term
Do NOT give antibiotics or antimotility agents for which strain?
Definition
EHEC. Remember you may need to give these patients plasmapheresis or blood transfusions.
Term
Second most common cause of diarrhea in infants. Infected in utero or during birth.
Definition
EPEC
Term
Had Bundle-forming pili (BFP) for adherence to form A/E lesions.
Definition
EPEC
Term
Watery, bloody diarrhea with fever =
Definition
EPEC
Term
This strain can move laterally within the epithelium.
Definition
EIEC
Term
Starts at watery diarrhea which could progress to bloody diarrhea with mucus (dysentery) and WBCs in feces.
Definition
EIEC
Term
This strain is found in the colon AND small intestine
Definition
EIEC
Term
This strain forms a biofilm on the surface of the microvilli. Leads to diarrhea in babies and HIV patients.
Definition
EAEC
Term
This strain leads to shortening and rounding of the microvilli leading to hemorrhagic necrosis.
Definition
EAEC
Term
This strain causes an elongation of microvilli.
Definition
DAEC.
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