Term
Common virulence factors for E.Coli |
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Definition
Endotoxin (LPS), Exotoxins for some, Adhesion molecules, capsule, Antibiotic resistance. |
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Term
The Polysaccharide core portion of LPS that is heat stable |
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Definition
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Term
Flagella on motile strains is called |
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Definition
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Term
The capsule is also called |
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Definition
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Term
What does E.Coli ferment? What are the products of this fermentation? |
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Definition
Ferments glucose to ACID and GAS |
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Term
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Definition
Gram negative Rods. It contains Lactose, which also makes it a differential medium. |
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Term
The exogenous source via fecally contaminated food or water leads to what type of disease? |
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Definition
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Term
If E.Coli is from an endogenous source it causes these types of diseases... |
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Definition
Extraintestinal diseases, UTIs and neonatal meningitis. |
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Term
What do differences in individual plasmids and integrated prophages lead to? |
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Definition
Differences in degree of virulence |
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Term
ETEC (Enterotoxigenic E.Coli) is the most common cause of... |
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Definition
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Term
Define ETEC, EHEC, STEC, EPEC, EIEC, EAEC, DAEC. |
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Definition
Enterotoxigenic E. Coli (Traveler's)
Enterohemorrhagic E. Coli (Shiga-toxin)
Enteropathogenic E. Coli
Enteroinvasive E. Coli
Enteroaggregative E. Coli
Diffuse aggregative E. Coli |
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Term
What are the different types of pili on different species of E. Coli called? |
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Definition
CFA = colonization factor.
They provide for different types of virulence |
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Term
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Definition
Heat Stable toxin increases cGMP |
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Term
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Definition
Heat-labile toxin increases cAMP |
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Term
STa and LT are toxins associated with which strain of E.coli? |
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Definition
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Term
Describe the pathogenesis of the watery diarrhea associated with ETEC. |
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Definition
LT and STa cause prolonged hypersecretion of Cl- and water and inhibit reabsorption of Na+ leading to fluid in gut leading to watery diarrhea only |
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Term
Treatment of Traveler's Diarrhea |
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Definition
It is self limiting. Replace fluids with ORS (oral rehydration solution) which has Salt, Baking soda, Sugar, and Water. This is also known as Pedialite |
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Term
EHEC/STEC has what toxins? |
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Definition
Shiga-like or Vero toxin (SLT or VT) |
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Term
Your patient has watery, very bloody stool. What is the microbe responsible for this? |
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Definition
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Term
What part of the intestine does EHEC/STEC involved in? |
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Definition
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Term
What are two unique virulence factors that EHEC/STEC posses? |
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Definition
Intimin and Entero-hemolysin, which causes BLOODY poo. |
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Term
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Definition
This is the most common E.coli breakout.
It is in the EHEC family. |
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Term
Organisms efface (rub off) the microvilli and induce polymerization of actin filaments leads to form cuplike pedestal leads to intimin secretion allows intimate attachment to the surface of the host cells (A/E lesions) leads to secrete SLT (production controlled by a lysogenic phage) leads to inhibits protein synthesis by nicking the 60S ribosome.
What organism does this describe? |
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Definition
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Term
This bug carries the Locus of enterocyte effacement pathogenecity island that allows it to encode for the ability to induce attaching and effacing lesions on the host mucosa. |
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Definition
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Term
Maconkey + Sorbitol is a differential for... |
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Definition
non-EHEC. O157:H7 is a non-sorbitol fermented so it will have clear colonies. |
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Term
Outbreaks of EHEC are usually associated with |
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Definition
Fast food hamburger joints (Jack in the Box) |
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Term
Hemolytic-uremic syndrome occurs in what populations and are associated with which strain? |
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Definition
HUS occurs in children and the elderly. It is associated with EHEC and leads to acute renal failure in children. This is seen as thrombotic microangiopathy and thrombocytopenia. |
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Term
Do NOT give antibiotics or antimotility agents for which strain? |
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Definition
EHEC. Remember you may need to give these patients plasmapheresis or blood transfusions. |
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Term
Second most common cause of diarrhea in infants. Infected in utero or during birth. |
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Definition
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Term
Had Bundle-forming pili (BFP) for adherence to form A/E lesions. |
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Definition
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Term
Watery, bloody diarrhea with fever = |
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Definition
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Term
This strain can move laterally within the epithelium. |
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Definition
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Term
Starts at watery diarrhea which could progress to bloody diarrhea with mucus (dysentery) and WBCs in feces. |
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Definition
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Term
This strain is found in the colon AND small intestine |
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Definition
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Term
This strain forms a biofilm on the surface of the microvilli. Leads to diarrhea in babies and HIV patients. |
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Definition
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Term
This strain leads to shortening and rounding of the microvilli leading to hemorrhagic necrosis. |
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Definition
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Term
This strain causes an elongation of microvilli. |
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Definition
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