Term
| Single occupancy theory-intensity |
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Definition
| number or receptor occupied |
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Term
| Single occupancy theory-maximum response |
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Definition
| all receptors have drug molecules attached |
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Term
| Modified occupancy theory |
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Definition
| different drugs have different affinity for receptor sites |
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Term
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Definition
| drugs have different abilities to stimulate receptors |
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Term
| Minimum effective concentration |
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Definition
| amoutn of drug required to produce a therapeutic effect |
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Term
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Definition
| level of drug that results in serious adverse effects |
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Term
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Definition
| drug concentration between the minimum effective concentration and the toxic concentration |
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Term
| Factors that influence that dose of a drug |
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Definition
1. potency and efficacy
2. Maintenance, & loading dose
3. Therapeutic index |
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Term
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Definition
| amount of drug needed to produce effect |
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Term
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Definition
| How well a drug produces its effect |
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Term
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Definition
| Shows the relationship between dose of drug & response it produces |
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Term
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Definition
| induced response; response will reach a plateau |
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Term
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Definition
| large change in dose/small change in effect |
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Term
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Definition
| small changes in dose/large change in effect |
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Term
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Definition
| the dose that continues to keep the drug in the desired therapeutic range |
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Term
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Definition
| Large than the standard dose used to quickly achieve steady state |
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Term
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Definition
| Evenly distributed concentration of a drug. rate of administration = rate of drug. takes 4-5 half-lives |
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Term
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Definition
| The time needed to reduce the plasma concentration of a drug to 50% |
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Term
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Definition
The drug margin of safety. Ratio of efffective dose to lethal dose.
TI= LD50/ED50 |
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Term
| median effective dose ED50 |
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Definition
| The dose needed to produce a therapeutic effect in 50% of the drug-tested populations |
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Term
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Definition
| The dose that is lethal to 50% of the drug-tested populations |
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Term
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Definition
| Dangerous drug, monitor closely |
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Term
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Definition
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Term
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Definition
| Drugs customized for patients with specific gnetic similarities. DNA testing prior to drug therapy |
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Term
| Causes of adverse effects |
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Definition
| Too much of a therapeutic response. Other pharmacodynamic effect. |
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Term
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Definition
| Altered physiologic reaction. Anaphylaxis |
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Term
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Definition
| Unusual, abnormal, or peculiar response to a drug |
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Term
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Definition
| Injury to the CNS. S/S: drowsiness, auditory and visual disturbances, restlessnesss, nystagmus, tonic-clonic seizures |
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Term
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Definition
| Injury to the liver. Manifestatiosn: hepatitis, jaundice, elevated liver enzymes, fatty infiltration of the liver |
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Term
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Definition
| Injury to the immune system |
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Term
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Definition
| Injury to the kidneys. Manifestation: acute tubular necrosis |
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Term
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Definition
| Injury to the heart. Characteristics: transient cardiac arrhythmias, depression of myocardial function, CHF |
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Term
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Definition
| Injury to eighth cranial nerve: inner ear or auditory nerve damage. S/S: tinnitus, sensorineural hearing loss, lightheadedness, vertigo, nausea and vomiting |
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Term
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Definition
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Term
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Definition
| When we block muscular cholinergic |
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Term
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Definition
| Bone marrow depression, affects levels of blood products (RBC, platelets) |
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Term
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Definition
| Mask signs and symptoms of infection |
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Term
| Drug interactions: drug-drugs |
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Definition
| Prescriptions, OTC, herbal, vitamin supplements |
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Term
| Drug interactions: Drug-food |
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Definition
| Grapefruit juice, milk, vitamin K, tyramine |
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Term
| Drug interactions: GI absorption |
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Definition
| Drug binding in GI tract, motility, ph, intestinal flora |
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Term
| Pharmacodynamic interactions: additive effect |
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Definition
| (1+1=2) one drug, then another drug=two |
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Term
| Pharmacodynamic interactions: synergistic effect |
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Definition
| (1+1=3)when two different drugs= a greater effect. |
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Term
| Pharmacodynamic interactions: Potentiation |
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Definition
| (1/2 + 1=2) when one of the drugs is increased |
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Term
| Pharmacodynamic interactions: Antagonistic interactions |
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Definition
| (1 +1=0)Two drugs together and then neither one of them work |
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Term
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Definition
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Term
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Definition
| Patient may be more likely to have adverse reactions |
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