Term
| Insulin-dependent diabetes mellitus |
|
Definition
- DQ2 and DQ8 increase risk
- DQ 6 is protective
- DR4 can raise or lower risk |
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|
Term
| Abacavir -hypersensitivity in HIV |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
HLA-DQB1*06:02 and
TCR for hypocretin |
|
|
Term
Behset's Disease
(Silk Road Disease) |
|
Definition
|
|
Term
|
Definition
HLA-DQB1*02:01 or
HLA-DQ8
High NPV |
|
|
Term
| Steven-Johnson's Syndrome |
|
Definition
In Asians:
- HLA-B*15:02 in presence of carbamazepine/phenytoin leads to SJS
In Northern Europeans/Asians:
- HLA-B*58:01 in presence of allopurinol leads to SJS |
|
|
Term
| Transfusion related acute lung injury (TRALI) |
|
Definition
Antibodies from donor bind WBC of the recipient and form a complex that clogs the pulmonary vasculature resulting in vascular permeability and pulmonary edema leading to fluid and protein in the alveoli
Symptoms include rapid onset of:
- dyspnea
- cyanosis
- hypotension
- Fever
- Chills
- Pulmonary edema |
|
|
Term
| Platelet refractory patients |
|
Definition
Platelets express HLA class 1 which recipient can have antibodies for leading to the destruction of platelets (refractory disease)
To avoid this, you must match HLA/HLP-1 platelets to the recipient to avoid this |
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