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ROB exam 1
psych drugs
107
Pharmacology
Graduate
02/10/2013

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Term
Fluoxetine
Definition
Depression
2D6 inhibitor
Kids, Long 1/2 life, Pulmonary HTN in neonates
Term
Sertraline
Definition
SSRI
Term
Paroxetine
Definition
SSRI 2d6 inhibitor
Term
Citalopram
Definition
SSRI
LONg QT
NTE 40 mg/d
Term
Fluvoxamine
Definition
SSRI
OCD use only
Term
Venlafaxine
Definition
SNRI
ghost tablet
ADR-dd bp increase, discontinuation syndrome
Term
Desvenlafaxine
Definition
SNRI
Ghost tablet
ADR-dd bp increase, discontinuation syndrome
Term
Duloxetine
Definition
SNRI
+Pain from DM neuropathy, fibromyalgia, chronic msc pain
Term
Milnacipran
Definition
SNRI
+Fibromyalgia only
Term
Vilazodone
Definition
SSRI+Partial 5HT Receptor agonist
last line depression
do not use with MAOI
Term
Buspirone
Definition
Anxiety med
Term
Alprazolam
Definition
BZD (xanax)
anxiety
Term
Clonazepam
Definition
BZD
anxiety
Term
Lorazepam
Definition
BZD
anxiety
+seizures, anesthesia, elderly use
Term
Diazepam
Definition
BZD
anxiety for children
Term
Midazolam
Definition
BZD
anxiety+anesthesia
Term
Buproprion
Definition
Antidepressant
CY2D6 inhibitor
Good for sexual dys, wt gain, smoking
Bad for anxiety, seizures
Term
Trazadone
Definition
Antidepressant
+Insomnia
ADR- QT and Priapism
Term
Mirtazapine
Definition
Antidepressant
+Insomnia or Anorexia
ADR-Sedation at low dose, wt gain
Term
Imipramine
Definition
TCA (tertiary)
MDD+Enuresis in kids
Term
Clomipramine
Definition
TCA (tertiary)
+OCD
Not for MDD
Term
Amytriptylline
Definition
TCA (tertiary)
MDD use
Term
Doxepin
Definition
TCA (tertiary)
MDD+Insomnia sleep maintenance
Term
Desipramine
Definition
TCA (secondary)
MDD
Term
Nortriptyline
Definition
TCA (secondary)
MDD
Term
Phenelzine
Definition
MAOI (A)
depression + Hyperphagia/Hypersomnia
ADR-Tyramine foods
Term
Selegine
Definition
MAOI (B)
High dose=MDD, Low dose =PD
24h patch
ADR c tyramine rich foods!
Term
Lithium
Definition
Bipolar Disorder
Intrx- TZD, Nsaid, aceI
ADR-Tremor, Nocturia, Teratogen D
Monitor Renal, Ecg, preggers, thyroid
Term
Chlorpromazine
Definition
Schizo, mania, hiccups
Intrx-2D6 and 3A4 inhibito, QT agent
ADR-EPS, NMS, QTC, Prolactin increase
Term
Haloperidol
Definition
Schizo, Tourettes, sedation (depot) potent
Intx- 2D6 and 3A4 inhibitor, qt agents
adrs- EPS, NMS, QTC, prolactin
Term
Clozapine
Definition
Atypical antipsychotic
Refractory schizophrenia
Adr-Wt gain, seizure, *Agranulocytosis
Term
Risperidone
Definition
Atypical Antipsychotic
Term
Olanzapine
Definition
Atypical antipsychotic
+Depression
Wt Gain!
Term
Quetiapine
Definition
Atypical antipsychotic
+Depression
QT prolongation
Term
Ziprazidone
Definition
Atypical antipsychotic
QTc
Term
Aripiprazole
Definition
Atypical Antipsychotic
+depression
Term
Paliperidone
Definition
Atypical Antipsychotic
Term
Asenapine
Definition
Atypical antipsychotic
dont use it, allergic rxn
Term
Iloperidone
Definition
Atypical antipsychotic
QTc
Term
Lurasidone
Definition
Atypical antipsychotic
Term
Diphenhydramine
Definition
Antihistamine hypnotic
Long onset and duration
tolerance may develop
Term
Doxylamine
Definition
Antihistamine hypnotic
Long onset and duration
tolerance may develop
Term
Triazolam
Definition
Hypnotic BZD
Short onset and short duration
Teratogen
Term
Estazolam
Definition
Hypnotic BZD
teratogen
Term
Temazepam
Definition
Hypnotic BZD
Teratogen
Term
Flurazepam
Definition
Hypnotic BZD
Teratogen
Term
Quazepam
Definition
Hypnotic BZD
Term
Zaleplon
Definition
NBRA hypnotic
sleep onset and maintenance
shortest duration
falls, amnesia, and allergic rxn
Term
Zolpidem
Definition
NBRA hypnotic
sleep onset and maintenance
adr-falls, amnesia, allergic rxn
Term
Eszopiclone
Definition
NBRA hypnotic
sleep onset and maintenance
adr-falls, amnesia, allergic rxn
Term
Ramelteon
Definition
Melatonin Agonist
For falling asleep, fallers, travelers, chronic insomnia, or abuse concerns
Term
Methylphenidate
Definition
Stimulant
ADHD-short, int, and long acting
Term
Dexmethylphenidate
Definition
Stimulant
ADHD-Short and Long acting
Term
Dextroamphetamine
Definition
Stimulant
ADHD-Short and int acting
Term
Amphetamine-Dextroamphetamine
Definition
Stimulant (adderall)
ADHD- Short and long acting (double pulse)
Term
Lisdexamphetamine
Definition
Stimulant
ADHD Long acting
Term
Atomoxetine
Definition
Non Stimulant
ADHD- No abuse potential, can take at night, less effective
Black box for suicidal ideation
Term
Guanfacine
Definition
other ADHD drug
Kids adjunct or replacement to stimulants
Term
Clonidine
Definition
other adhd drug
adjunct or replacement to stimulants
intx- B blockers and CCBs=bradycardia
Adr-sedation and nightmares
Term
Tacrine
Definition
Old cholinesterase inhibitor for dementia
Term
Donepezil
Definition
cholinesterase inhibitor for mild-mod dementia
Intx- DO not use with anticholinergics
Term
Galantamine
Definition
Dementia med
Term
Rivastigmine
Definition
Dementia med (patch)
Term
Memantine
Definition
NMDA Receptor Agonist for moderate-severe dementia
Tamps down brain excitation via glutamate
Term
Sumatriptan
Definition
Migraine
SQ, nasal spray, and fastest onset
Term
Zolmitriptan
Definition
Migraine
ODT
Term
Rizatriptan
Definition
Migraine
ODT
Term
Almotriptan
Definition
Migraine
Term
Eletriptan
Definition
Migraine
Term
Noratriptan
Definition
Migraine tablet
slowest onset, lasts longest
Term
Frovatriptan
Definition
Migraine tablet
slowest onset, lasts longest
Term
Dihydroergotamine
Definition
Migraine ergot
For people not responding to triptans
Term
Ergotamine/caffeine
Definition
Migraine
Dont use
Term
Metoclopramide
Definition
Antiemetic c Migraine
IV
Term
Chlorpromazine
Definition
Also Antiemetic c migraine
IV/IM
adr- akasthesia!
Term
Levodopa
Definition
Parkinson
*On off syndrome *Wearing off syndrome
works on akinetic>tremor>postural instability
Term
Carbidopa
Definition
Parkinson
Blocks levodopa --> dopamine systemically
decrease N/V and orthostatic htn
Term
Entacopone
Definition
Parkinson
COMT inhibitor
Term
Ropinirole
Definition
Dopamine Receptor Agonist
+RLS
Term
Pramipexole
Definition
Dopamine Receptor Agonist
+RLS
Term
Rotigotine
Definition
Dopamine Receptor Agonist
+RLS
Term
Apomorphine
Definition
Dopamine Receptor Agonist
severe immobility
*makes you vomit!
Term
Rasagiline
Definition
MAOI (B)
For Parkinsons
tyramine food htn crisis
Term
Trihexyphemdyl
Definition
Anticholinergic for parkinsons
treat drug induced EPS and drooling
Term
Benztropine
Definition
Anticholinergic for parkinsons
Treat drug induced EPS and drooling
Term
Amantadine
Definition
NMDA Antagonist for parkinsons
for ldopa induced dyskinesias
adrs- Peripheral edema and Livedo reticularis (high dose)
Term
Carbamazapine
Definition
Na Channel antiepileptic
for chronic pain, neuralgia, may make absence and myoclonic sz worse
Autoinduce 2c9 and 3a4
Term
Oxcarbazepine
Definition
Na Channel antiepileptic
same as CBZ but greater hyponatremia
Term
Phenytoin
Definition
Na Channel antiepileptic
Prevent early seizure after TBI/NS
Autoinduces 2C9 and 3A4
ADR- gingival hypertrophy, fever, BMS, hypertrichosis
Term
Fosphenytoin
Definition
Na Channel antiepileptic
like phenytoin but faster admin and less IV complications
Term
Lamotrigine
Definition
Na Channel antiepileptic
for Newly diagnosed absence and bipolar maintenance
Term
Lacosamide
Definition
Na Channel antiepileptic
PR Prolongation!
Euphoria=Sched V
Term
Zonisamide
Definition
Na Channel antiepileptic
*Monitor Bicarb
adr-heat stroke, m acidosis, stones
Term
Rufinamide
Definition
Na Channel antiepileptic
Atonic Seizures
*Shortens QT
Term
Ezogabine
Definition
K channel antiepileptic
ECG monitor for QT
Euphoria=sched V substance
Term
Ethosuximide
Definition
Ca channel antiepileptic
Absence Seizures
Monitor cbc and lft
adr behavioral, hyperactivity adhd and psychoses
Term
Gabapentin
Definition
Ca channel antiepileptic
Post-herpetic neuropathy, RLS
*Not metabolized, increase myoclonic seizure
Term
Pregabalin
Definition
Ca channel antiepileptic
Firbromyalgia and neuropathy
*not metabolized, wt gain, sched V for euphoria
Term
Phenobarbitol
Definition
Gaba AED
autoinducer of 2c9 and 3a4
monitor cbc, lfts, ca, vit d
Term
Clobazam
Definition
gaba aed
BZD for *Atonic Seizure
Term
Clonazepam
Definition
Gaba AEd
BZD for *atonic seizures
Term
tiagabine
Definition
gaba aed
monitor cbc and cmp
New onset *Status Epilepticus/seizures with off label use
Term
Vigabatrin
Definition
Gaba aed
*Monotherapy for infantile spasm
adr-*Retinal toxicity
Term
Valproate
Definition
Use for Mania, migraine proph, AED
Monitor cbc and ammonia
adr-parkinsonism, wt gain, hepatotox, androgens,
teratogen=spina bifida, cleft palate
Term
topiramate
Definition
NMDA Antagonist (monitor bicarb)
Migraine Proph, wt management
adr hypothermia, m acidosis, kidney stones
*Hypospadias!
Term
Felbamate
Definition
Last line seizure med LGS
Adr- Fatal aplastic anemia, require written consent
Hepatic failure
Term
Levatiracetam
Definition
Prevent early seizures following tbi/ns
adr-behavioral
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