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-RNA Viruses
-RNA Viruses
69
Microbiology
Graduate
12/12/2011

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Cards

Term
What is needed to be included in the viron with all -RNA viruses?
Definition
RNA Dependant RNA polymerase
Term
BUZZWORD: Bullet Shapped
Definition
Rhabdo viruses
Term
What is the main vector for rabies in the US?
Definition
Raccoons
Term
How do you get rabies?
Definition
Getting bit from a rabid animal
Term
In an infected person with Rabies, where would you swab to test for the presence of rabies?
Definition
the saliva
Term
BUZZWORD: Hyrdophobia
Definition
Rabies (Rhabdo virus)
Term
BUZZWORD: Negri bodies
Definition
Rabies (Rhabdo virus)
Term
What major disease does the Filo virus cause?
Definition
Ebola (and Marburg but more rare)
Term
BUZZWORD: Lassoshaped
Definition
Ebola (Filo virus)
Term
Pt presents with bleeding from the eyes, ears, mouth, nose, and downstairs... what do they have?
Definition
Ebola (Filo virus)
Term
How is Ebola transmitted?
Definition
Respiratory and direct contact(blood)
Term
What part of the world is Ebola usually found?
Definition
Africa and England
Term
How is the Bunya virus transmitted?
Definition
mosqutios rodents and ticks (know Rodents for exam)
Term
How do you get Hantavirus Pulmonary Syndrom (HPS)?
Definition
Inhaling Rodent poo =)
Term
What is central to the pathogensis of the HSP virus?
Definition
Functional impairment of vascular endothelium
Term
How do the symptoms of HSP layout?
Definition
First you get a non specific illness (flu like with SOB and Tachycardia) and then BOOM, you enter the cardiopulmonary phase and shit goes down.
Term
What are 3 observations to diagnose HPS?
Definition
1. Area of country
2. Massive pulmonary infection
3. Death
Term
What virus is appears studded due to ribosomal attachment?
Definition
Arena virus
Term
What 3 viruses/infections does the Reo Virus cause?
Definition
1. Reovirus
2. Rotovirus
3. Colorado Tick Fever Virus
Term
What is special about the structure of the reo virus?
Definition
It has a double envelope
Term
How is the rotovirus transmitted?
Definition
Fecal-Oral
Term
What diease does the rotovirus cause?
Definition
Gastroeniritis
Term
What genera of influenza (orthomyxovirus) causes infections of humans/animals/both?
Definition
Influenza A= both
Influenza B+C= humans only
Term
What is hemagglutinin (HA), where is it located, and what types of viruses have it?
Definition
HA= protein on the influenza virus which allows the cells to enter by binding to sialic acid on the host cell. Its located on the envelope on the virus
Term
What is neuramindiase (NA), where is it located, and what ypes of viruses have it?
Definition
NA= enzyme which breaks down mucus that is located on the surface of the envelope on the influenza virus. It also, detaches sialic acid from HA so the virus can bind to other cells.
Term
What type of phenomena occurs about every decade with respect to influenza viruses?
Definition
Antigentic shift
Term
What envelope protein is ALWAYS altered in a antigentic shift?
Definition
HA
Term
Antigenic shift only occurs in which virus (be specific)?
Definition
Influenza A
Term
How does antigenic shift happen?
Definition
Influenza A viruses of 2 different strain infect the same cell. Each virus has 8 different segments that recombine to form a new virus that no one has antibodies for....uh oh
Term
What type of influenza virsus can do Antigenic drift?
Definition
Type A and B
Term
What is Antigenic Drift?
Definition
Small changes in the AA sequence of HA and NA due to RNA polymerases having no proof reading mechanisms.
Term
What is responsible for Pandemics?
Definition
Antigenic shifts
Term
What is responsible for epidemics?
Definition
Antigenic shifts
Term
How is the influenza virus transmitted?
Definition
respiratory droplets
Term
What is characteristic of the flu?
Definition
ABRUPT onset of high fever (102-104)
Headache

*No coryza associated with an influenza infection
Term
Once influenza enters the blood, what is its next target?
Definition
Nothing! Its only confined to the RT!
Term
What is the influnza's virus pathogensis technique? How does it cause disease?
Definition
Cilia are destroyed as well as mucus membrane secreting cells.
Term
What is the most common secondary infection with a influenza infection?
Definition
Strep pneumonia
Term
What form of vaccine is the flu mist?
Definition
Live attenuated.
Term
What 3 infections are caused by the Paramyxovirus?
Definition
Measles, Mumps, RSV
Term
What virus cause the Measles?
Definition
Morbilli virus (Paramyxovirus)
Term
How are the measles transmitted?
Definition
Respiratory droplets
Term
What are the 3 clinical symptoms does a pt with the measles present with?
Definition
3C's:
Cough
Conjunctivitis
Coryza
(photosensitivity sometimes too)
Term
What is the vaccine status for the measles?
Definition
Live-attenuated vaccine
Term
BUZZWORD: Koplik's Spots (on inner cheek)
Definition
Measles (morbilli virus; paramyxovirus)
Term
When are the measles contagious the most (with respect to the onset of symptoms)
Definition
Before the rash shows
Term
Where does the measles rash start?
Definition
Behind the ears and travels down
Term
What causes Subacute Sclerosing pan Encepalitis (SSPE)?
Definition
Measles (morbilli virus; paramyxovirus)
Term
What do you see first with measles, the rash or koplik's spots?
Definition
Koplik's spots in the mouth
Term
What can you see on cell cultures of measles patients?
Definition
Synatia
Term
BUZZWORD: Croup (Seal Cough)
Definition
Parainfluenza
Term
How is the parainfluenza virus transmitted?
Definition
Respiratory droplets
Term
What 3 clinical symptoms can you observe on pts with a infection with the parainfluenza?
Definition
Croup, tachypnea, tachycardia
Term
What will you see notice in a host cellular culture of a pt who is infected with parainfluenza?
Definition
host cell fusion (syncitia). It also causes hemaagglutination
Term
What parainfluenza serotypes give croup?
Definition
1+2
Term
What parainfluenza serotype is active all year round?
Definition
3
Term
What is a tell tale sign of MUMPS?
Definition
Huge ass parotid gland swelling (bilateral)
Term
Route of Mumps infection? (starts where.... can go to where)
Definition
Start in epitheial cells of URT and will go to parotid glands. Next it can enter the blood and go to testes can cause serility
Term
Why is it dangerous for men to have mumps?
Definition
They could become sterile (orchiditis)
Term
How is mumps transmitted?
Definition
Respiratiory droplets / direct contact
Term
BUZZWORD: Bilateral parotiditis
Definition
MUMPS!
Term
What is the vaccine called for MUMPS?
Definition
MMR
Term
What is the most common cause of fatal respiratory tract infections in infants?
Definition
Respiratory Syncital Virus (RSV)
Term
What types of HA and NA does RSV have?
Definition
NONE!
Term
What can RSV do that makes it so dangerous?
Definition
It can form mucus + fibrin plugs that clog the airway.
Term
Where is RSV's target once it hits the blood?
Definition
Nowhere, its localized to the URT
Term
When is RSV usually transmitted (time of year)?
Definition
Winter
Term
Transmission of RSV?
Definition
Respiratory droplets and hands via fomites
Term
BUZZWORD: Prominent Runny Nose
Definition
RSV
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