Term
what are the Skin manifestations of SLE x4?
what happens to the
brain,
heart,
lungs,
kidneys,
Joints? |
|
Definition
Malar rash, Discoid rash, Photosensitivity, Oral ulcers
B:psycosis, seizures, stroke,
H: pericarditis
L: pluritis
K: membranous glomerulonephritis
J: Arthritis present in 90% |
|
|
Term
| What happens to the head and eyes in SLE? x3 |
|
Definition
Allopecia
eyes: photophobia, retinal leasions( cotton wool spots, blindess |
|
|
Term
what would a CBC show on SLE?
What lab finding is Specific but not sensitive
What Lab finding is Sensitive but not Specific |
|
Definition
decreased: RBC,WBC,Platlets
ANA
Anti-DS,SM |
|
|
Term
What is the treatment for a acute lupus flare?
what is the tx for mildly chronic disease?
what controls progression of the disease? |
|
Definition
High dose bolus of steroids
Hydroxychloroquine (limited to skin and joint
Belimumab |
|
|
Term
what happens in Antiphospholipid Syndrome?
name the antibodies |
|
Definition
IgG and IgM attack phospholipids
Lupus anticoagulant
Anticardiolipin Antibodies |
|
|
Term
What are the ass S&S with Antiphopholipid syndrome?
what are the lab findings |
|
Definition
thrombosis, recurrent spontaneous abortions,
APL= clotting + elevated aPTT and normal PT |
|
|
Term
What is the BITest for APLS?
explain
What is the Most specific test for APLS |
|
Definition
a Mixing study- pt plasma is mixed with normal plasma if (+) the PTT will remain elevated instead of go down
Russell viper venom Test RVVT |
|
|
Term
In Antiphospholipid Syndrome what is the treatment for a spontaneous abortion in the process of happening?
to prevent recurrence? |
|
Definition
no available treatment
Heparin and aspirin to prevent |
|
|
Term
What is another name for Limited Scleroderma?
What are the symptoms? x5 |
|
Definition
CREST syndrome
Calcinosis
Raynaud
Esophageal dysmotility
Sclerodactyly,
Telegiectasis |
|
|
Term
What does slceroderma do to the:
hands
Skin
GI
Renal
Lung
Cardiac
and what is the treatment for each |
|
Definition
Reynaud syndrome -CCB
fibrosis of hands-
esophageal dismotility- PPIs for GERD
Hypertensive crisis -ACEi
Restrictive lung disease-Cyclophosphamide
pulm htn-Bosentan ambrisentan,.....
myocardial fibrosis, pericarditis |
|
|
Term
What is the sensitive but none specific test of Scleroderma
Specific but not sensitive
what is present in about half |
|
Definition
ANA
SCL-70
Anticentromere(extremely specific) |
|
|
Term
| What slows underlying disease in limited scleroderma? |
|
Definition
Crest syndrome
Methotrexate |
|
|
Term
What muscular problems are seen with inflamitory myopathies?
What skin problems are seen with dermatopyosistis? |
|
Definition
difficulty getting up from a seated position or walking up stairs
&
Dysphasia
Malar,
Shawl sign:erythema of face, neck shoulders, upper chest and back
Heliotrpe rash: edema nad purplish discoloration of the eyelids
Gottron papules, scaly patches over the back of the hands |
|
|
Term
What is the BITest for Inflamation myopathies?
MATest? |
|
Definition
BIT: CPK and aldolase
MAT: muscle biopsy |
|
|
Term
What is the treamtent for Polymyositis and Dermatomyositis?
if that does not work?
for skin leasions? |
|
Definition
Steroids
----------
if not work:
Methotrexate, azathioprine, IVIG, mycophenolate
Hydroxychloroquine helps skin |
|
|
Term
What is the treamtent for Polymyositis and Dermatomyositis?
if that does not work?
for skin leasions? |
|
Definition
Steroids
----------
if not work:
Methotrexate, azathioprine, IVIG, mycophenolate
Hydroxychloroquine helps skin |
|
|
Term
What is the most dangerous complication of SLE?
what is the BITest?
What is the BITest on blood?
What is the MATest? |
|
Definition
Lymphoma
Schirmer test- paper on eye to see if dry
Anti SS-A and SS-B (Ro and La) present in 60%
MAT- lip or parotid gland biopsy |
|
|
Term
What is the Best initial therapy for SLE
Drugs? |
|
Definition
sips of water, sugar free gume, fluoride txs, artificial tears
Piocarpine and cevimeline increase acetylcholine and saliva |
|
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