Term
|
Definition
- any of a group of viruses that contain two single-strand linear RNA molecules
- carries its genetic blueprint in the form of RNA instead of DNA |
|
|
Term
| Steps of infection caused by retrovirus (5 steps) |
|
Definition
1. Reverse transcriptase is used to make viral DNA from viral RNA
2. cDNA strand is inserted into host chromosome
3. Host-cell RNA polymerase makes virus-related RNA
4. Translated into viral proteins that are used to make the virus envelope.
5. Assembly, budding and release |
|
|
Term
Retroviruses and variability
Reverse transcription is highly error prone
Fast replication cycle
What does this mean?
What effect would this have on a treatment course? |
|
Definition
because of the fast speed in which retrovirus goes thru replication cycle it cause many errors to occurs.
what does this mean? sequence variability
what effect would this have on a treatment course? hard to treat and is constantly changing |
|
|
Term
|
Definition
Virus leads to AIDS
-belongs to a subset of retroviruses called Lentivirus
-HIV infects the CD4+T cells and begins to replicate rapidly
- disables the bodies immune system |
|
|
Term
|
Definition
| when u first get infected. start with a lot of t cells, lose a lot once u get HIV, and then there is a spike. then steadily decrease until there is 0 tcells left |
|
|
Term
| TREATMENT COURSE FOR HIV (4 of them) |
|
Definition
-Highly active antiretroviral therapy (HAART) (most common to start. based on RTI)
-Protease inhibitor based therapy
-2 reverse transcriptase inhibitors + protease inhibitor (very error prone and different viral sequences)
-Extremely regimented to see benefit (takes a long time, and even 1 day of missing medicine could mess it up) |
|
|
Term
|
Definition
-Prevent T-cells that have been infected with HIV from producing new copies of the virus
-Once HIV's genetic material (RNA) is inside DNA, the cell produces genetic material that must be cut up and put together correctly to form new copies of the virus (protease)
-Combination therapy can block the replication of HIV in the blood |
|
|
