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Reticular Formation
Description and definitions of reticular formation in human brainstem
35
Medical
Graduate
03/15/2012

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Term
The precerebellar nuclei of the reticular formation project to the?
Definition
Cerbellum
Term
Raphe nuclei provide what kind of input and where? Modulates?
Definition
Seritonergic input to brain and spinal cord with modulation of sensory input and consciousness.
Term
Central nuclear group of the reticular formation gives rise to what tract and what other reticular system?
Definition
Gives rise to the reticulospinal tract and the reticular arousal system.
Term
The lateral parvocellular zone coordinates what?
Definition
Coordinates motor/sensory signals for things such as chewing and swallowing.
Term
Respiratory control zones of the reticular formation contain what substructures?
Definition
parabrachial nuclei, superficial medullary neurons and dorsal and ventral respiratory neuronal groups.
Term
Where does precerebellar nuclei receive its afferents from?
Definition
wide area of cortex containing highly intergrated sensory input that then projects to the cerebellum
Term
where do the raphe nuclei lie within the spinal cord? What NT is used?
Definition
extend from the medulla to the midbrain and located near the midline (raphe). Serotonin is the NT. Used for motor and sensory partes
Term
What are the divisions of the raphe nucleus? Implications?
Definition
divided by which way the axons go. Some go rostrally to the brain and some caudally to the spinal cord. Certain drugs affect certain parts
Term
What are the two raphe nuclei in the medulla?
Definition
the raphe nucleus magnus and raphe nucleus pallidus
Term
Where do the neurons of the medullary raphe (magnus and pallidus) project?
Definition
brainstem and spinal cord to affect motor and sensory.
Term
are projections of the magnus bilateral, unilateral, ipsilateral, or contralateral?
Definition
bilateral in the dorsal funiculus of spinal cord.
Term
If you stimulate the raphe nucleus magnus, what effect do you see?
Definition
analgesic w/o loss of tactile sense.
Term
Considering stimulatio of raphe magnus results in analgesia, what superior structure is it going to communicate with?
Definition
central (periaqueductal) gray in the midbrain.
Term
what NT is used by the periaqueductal gray for pain modulation?
Definition
enkephalins
Term
enkephalins are used by pain modulating neurons originating in the central gray. What other substance is similar and can bind the same receptors?
Definition
opiates.
Term
what autonomic functions is the raphe nucleus magnus related to?
Definition
provides preganglionic automonic fibers to the DMN of X, solitary, Spinal 5 for GVE.
Term
what part of the nuclei of the raphe are the magnus and pallidus parts?
Definition
descending parts
Term
The raphe nucleus pallidus performs what function and projections travel where?
Definition
It is located inferior to the magnus and provides motor modulation which travels in the anterior funiculus.
Term
the ascending portions of the nucleus raphe come from what areas of the brain?
Definition
prefrontal cortex, interpeduncular nucleus, and VTA
Term
where do the projections of the ascending nuclei raphe go?
Definition
go to wide areas of the cortex, thalamus, limbics. Pretty much everywhere.
Term
The widespread projections of the raphe nuclei (ascending) use what NT?
Definition
Serotonin. This is why SSRI's are very effective in treatment of Serotonin disorders
Term
What are the primary functions of the central nuclear group?
Definition
related to motor activities, sensory and activation of brainstem and cortex.
Term
the motor related part of the central nuclear group give rise to what tract?
Definition
medullary and pontine reticulospinal tracts.
Term
what controls the central nuclear groups motor function?
Definition
motor cortex, premotor area, cerebellum, superior colliculus and spinal cord.
Term
what is the main output of the central nuclear group?
Definition
motor activity.
Term
in the brainstem, the medial reticulospinal tract is known as the ?
Definition
pontine reticulospinal tract
Term
in the brainstem, the lateral reticulospinal tract is called the ?
Definition
medullary reticulospinal tract.
Term
What does the lateral reticulospinal (medullary) tract do?
Definition
descends bilaterally to spinal cord and inhibits spinal motor neurons and reflexes. Responsible for atonia in REM sleep.
Term
the pontine reticulospinal tract does what?
Definition
descend ipsilaterally and is excitatory to the proximal limb and postural muscles.
Term
what part of the central nuclear group has to do with eye movement?
Definition
Paramedial Pontine Reticular Formation
PPRF
Term
What does the PPRF coordinate?
Definition
lateral and vertical conjugate gaze and more copmlex eye movements.
Term
Where are the sensory receiving nuclei of the central nuclear group?
Definition
just lateral to the motor
Term
where do the efferents of the central nuclei project rostrally and via what route?
Definition
project ventrally through the CTT to the intralaminar nuclei of the thalamus, zona incerta, and substantia inominata (to broad cortex)
Term
what are the two important things carried by the CTT and which is more important?
Definition
taste and reticular projects conveying sensory innervation. The later is more important.
Term
whithout the sensory portions of the central nuclear group, what will the patient show?
Definition
a coma
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