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Respiratory
Respiratory exam 3
88
Pathology
Undergraduate 2
03/20/2012

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Term
MEDIASTINUM
Definition
THE SPACE BETWEEN THE LUNGS
and is the most outer membrane.
Term
Parietal pleura
Definition
lines the pulmonary cavities adheres to the thoracic wall, the mediastinum, and the diaphragm.
Term
visceral pleura
Definition
closley covers the lungs and is adherent to all its surfaces. This layer is right before the lungs.
Term
Pleural Effusion
Definition
an abnormal collection of fluid or exudate in the pleural cavity
Term
Pleural Space
Definition
space between the between parietal and visceral.
Term
what are the respiratory muscles?
Definition
1)diaphragm: it is the principle muscle of inspiration.
2) accessory muscles of inhalation:
*external intercostals
*scalene
*sternocleidomastoid
3) accessory muscles of exhalation
*internal intercostals
*abd muscles
Term
what are intercostal muscles and what do they do?
Definition
are several groups of muscles that run between the ribs, and help form and move the chest wall. The intercostal muscles are mainly involved in the mechanical aspect of breathing. These muscles help expand and shrink the size of the chest cavity when you breathe. They aid in quiet and forced inhalation, are responsible for the elevation of the ribs
Term
What is lung compliance?
Definition
a measure of the ease of expansion of the lungs and thorax, a measure of change in lung volume that occur with a change in intrapulmonary pressure. It’s determined by the elastin and collagen fibers of the lung, water content, and surface tension.
Important factor is surface tension in the alveoli.
Term
what are three compliances they affect the inflation of the lungs and how easily they can expand?
Definition
elastin and collagen fibers, water content, and surface tension.
Term
what is the purpose of Surfactant?
Definition
is a complex substance containing phospholipids and a number of carbohydrates. This essential fluid is produced by the Type II alveolar cells, and lines the alveoli and smallest bronchioles. Surfactant reduces surface tension throughout the lung, thereby contributing to its general compliance.
Surfactant lowers surface tension, increases lung compliance and ease of inflation, provides for stability and even more inflation of alveoli, and assists in preventing pulmonary edema by keeping alveoli dry.
Term
Surfactant reduces _______________?
Surfactant contains what substance?
Definition
surface tension
phospholipids
Term
What are the types of lung volumes?
Definition
Tidal Volume, Inspiratory Reserve(IRV),
Expiratory Reserve(ERV), Residual Volume.
Term
TIDAL VOLUME (TV)
Definition
THE AMOUNT OF AIR THAT MOVES INTO AND OUT OF THE LUNGS DURING NORMAL BREATHING.
Term
INSPIRATORY RESERVE (IRV)
Definition
THE MAXIMUM AMOUNT OF AIR THAT CAN BE INSPIRED IN EXCESS OF NORMAL TV AFTER A NORMAL BREATH.
Term
EXPIRATORY RESERVE (ERV)
Definition
THE MAXIMUM AMOUNT OF AIR THAT CAN BE EXHALED IN ECCESS OF NORMAL TV BREATHED OUT.
Term
RESIDUAL VOLUME
Definition
THE AIR THAT REMAINS IN THE LUNGS AFTER EXPIRATION, THIS INCREASES WITH AGE.
Term
LUNG CAPACITIES
Definition
VITAL CAPACITY, INSPIRATORY CAPACITY, FUNCTIONAL RESIDUAL CAPACITY, TOTAL LUNG CAPACITY.
Term
VITAL CAPACITY EQUATION
Definition
VC = IRV + TV +ERV AND IS THE AMOUNT OF AIR THAT CAN BE EXHALED.
Term
WHAT IS VITAL CAPACITY
Definition
the maximum amount of air that can inspired in excess of normal + the amount of air that moves into and out of the lungs during normal breathing + the maximum amount of air that can be exhaled in excess of normal TV. (she said to know this)
Term
INSPRIATORY CAPACITY
Definition
AMOUNT OF AIR WE BREATH IN
Term
FUNCTIONAL RESIDUAL CAPACITY
Definition
AMOUNT OF AIR THAT REMAINS IN THE LUNGS AT THE END OF NORMAL EXPIRATION.
Term
TOTAL LUNG CAPACITY
Definition
The sum of all volumes in the lungs.
Term
Nhat are the Dynamic Lung Functions?
Definition
Forced vital capacity, forced expiratory volume, FEV (1.0), minute volume, maximum voluntary ventilation.
Term
Maximum Volutary Ventilation
Definition
amount in and out during a set period of time.
Term
Forced Expiratory Volume
Definition
Term
FEV (1.0) =
Definition
one second
Term
Gas Exchange:
Oxygen moves from ______ into ______?
Definition
alveolar air into blood
Term
Gas Exchange:
Carbon dioxide moves from ____ to ____?
Definition
blood into alveolar air
Term
True or False:
oxygen moves from alveolar air into the blood?
Definition
true
Term
What is the primary function of the lungs?
Definition
ooxygenation of blood and removal of carbon dioxide.
Term
Name the three primary functions of the lungs?
Definition
ventilation, perfusoin, diffusion.
Term
True or False?
C02 could result in acidosis?
Definition
True
Term
Ventilation
Definition
Exchange of gases
Term
Perfusion
Definition
Flow of blood through the pulmonary capillary bed, provides blood flow to the gas exchange portion of the lungs, it filters blood, removes most of the thromboemboli, and serves as a reservior for blood on left side of the heart.
Term
Diffusion
Definition
Refers to the movement of gases in the alveoli and actoss the areolar-capillary membrane, its affected by the pressure of gas across the membrane, the availability of suface area, the thickness is passes through, and the characteristics of the gas.
Term
True or False?
blood will go to parts of the lungs that do have oxygen?
Definition
FALSE!! Blood will ONLY go to parts of the lungs that do not have oxygen!!
Term
Perfusion without ventilation will result in low ventilation. Name an example?
Definition
Incomplete expansion of the lungs such as in atelectasis or shunt.
Term
Shunt
Definition
Refers to blood that moves from the right to left side of the circulation without being oxygenated. There are 2 types, physiologic shunt with mismatching of ventilation and perfusion resulting in insufficient ventilation for O2 usually from destructive lung disease
Term
Name two factors that will interfere with the dead air space?
Definition
Pulmonary embolism and a shunt
Term
What are the normal values for PaO2 and PO2?
Definition
PO2 = represents levels of dissolved oxygen in plasma of arterial blood and are normally > 80mmHg.
PCO2 = 35-45mmHg
Term
Hemoglobin is the main transporter for what?
Definition
oxygen, it carries about 98-99% of oxygen in the blood.
Term
What does P02 represent?
Definition
PO2 represents levels of dissolved oxygen in plasma of arterial blood.
Term
Oxyhemoglobin
Definition
Hemoglobin contains bound O2, a compound formed from hemoglobin on exposure to alveolar gas in the lungs.
Term
A little something about oxygen, you should already know.
Definition
Oxygen moves across membrane through plasma and into red blood cell.
Term
What are the normal values for oxyhemoglobin?
Definition
95-97% saturation
Term
How many oxygen molecules can a hemogobin hold?
Definition
4
Term
What are the normal lab values for ph?
PaO2?
PaCO?
HCO3?
Definition
Ph: 7.35-7.45
PAO2: 80-100
PACO2: 35-45
HCO3: 22-26
Term
What is oxygen capacity?
Definition
the amount of oxygen the blood can hold
Term
How can anemia effect a pt?
Definition
An anemic person may have normal PO2 and hemoglobin saturation level but decreased oxygen content because of the lower amount of hemoglobin for binding oxygen.
Term
Additional information on Effect of anemia.
Definition
Effect of anemia on the oxygen carrying capacity of blood. The hemoglobin can be completely saturated but the oxygen content of blood of reduced. It is the oxygen content of blood that determines the amount of oxygen that is carried in the blood and delivered to tissues. An anemic person may have normal PO2 and hemoglobin saturation level but decreased oxygen content because of the lower amount of hemoglobin for binding oxygen. They would feel tired because of the decreased O2 the cells need.
Term
Oxygen affinity:
•Left shift: A
Definition
Decrease in metabolism, decrease in pcO2, increase in pH, alkaline, decrease in body temp
Term
Oxygen affinity:
•Right shift: C
Definition
Increase in metabolism, increase in temp, increase in Co2, acidic, decrease in pH, anemia, heart failure.
Term
Right shift for oxygen release shows signs of what type of complication?
Definition
Heart failure
Term
Left shift for oxygen release shows signs of what type of complication?
Definition
Alkalosis
Term
What does left shift represent?
Definition
Left shift represents an increased affinity of hemoglobin for oxygen and occurs in situations associated with decrease in tissue metabolism, such as alkalosis, decreased body temp and decreased PCO2 levels. Left shift will also see a decrease in metabolism, decrease in temperatures, and a decrease in CO2, so pt will be alkalotic.
Term
Name a byproduct of oxygen?
Definition
Lactic Acid
Term
If blood released half of its oxygen to the tissue, would that be considered a Left or Right shift?
Definition
Term
Most body tissues have a PO2 of ____mmHg?
Definition
40-60 mmHg
Term
What is the definition for carbaminohemoglobin?
Definition
Carbon dioxide is bound to hemoglobin
Term
What are the normal values for PACO2 or PC02?
Definition
35-45 mmHg
Term
Explain Carbaminohemoglobin?
Definition
Carbaminohemoglobin- the combination of carbon dioxide with hemoglobin is a reversible reaction, in the lungs the highly acidic hemoglobin has a lesser tendency to form carbaminohemoglobin and CO2 is released into alveoli.
35-45
Term
As a pt is exhaling, what is occuring?
Definition
As you exhale you remove CO2 from your blood and also decrease the amount of carbonic acid, raising your blood ph.
Term
?? If you do exhale correctly your blood levels will become? Acidic or Alkalitic?
Definition
Acidic because your body is holding onto the CO2.
Term
Carbaminohemoglobin: just a little note
Definition
Carbaminohemoglobin- the combination of carbon dioxide with hemoglobin is a reversible reaction, in the lungs the highly acidic hemoglobin has a lesser tendency to form carbaminohemoglobin and CO2 is released into alveoli.
35-45
Term
What is the function of Chemoreceptors?
Definition
They can adjust respiration rate
Term
Describe the function of Central Chemoreceptors.
Definition
They measure PCO2 and PH in the cerebrospinal fluid & increase respiration when PCO2 increases or PH decreases.
Term
Describe the function of Peripheral Chemoreceptors (carotid & aorta).
Definition
They measure PO2 in arterial blood & Increase respiration when PO2 is < 60mmhg.
Term
What receptors will kick in if the pts PO2 is less than 60 in the arterial blood?
Definition
Peripheral Chemoreceptors
Term
A receptor in the cerebrospinal fluid is stimulated, what will occur and what is the name of the chemoreceptor?
Definition
The Central Chemoreceptors measure the PCO2 in the cerebrospinal fluid and when they are stimulated the pt. will begin to increase respiration when PCO2 increases or PH decreases.
Term
The ______ group of neurons in respiratory center is concerned with inspiration?
Definition
Dorsal
Term
What two groups of neurons contribute to the function of the respiratory center?
Definition
Pons and Medulla
The pacemaker of the respiratory center results from the cycling of respiratory center with the pons over the Pneumotaxic stimulation and the lower pons over the apneustic center. These two groups (pons, medulla) of neurons contribute to the function of the respiratory center in the medulla.
Term
Apneustic center & The Pneumotaxic center information.
Definition
The Apneustic center has an excitatory effect on inspiration, tending to prolong inspiration. The Pneumotaxic center switches inspiration of assisting in control of respiratory rate and inspiratory volume.
Term
Pneumotaxix inhibits?
Definition
Inspirations
Term
Apneustic?
Definition
Collapsed lung
Term
Where are the Central Chemoreceptors located?
Definition
Medulla. Here they sense changes in the blood carbon dioxide. An increase in carbon dioxide levels produce an increase in ventilation that reaches its peek within one minute.
Term
In general, what do chemoreceptors monitor?
Definition
Blood levels of oxygen, carbon dioxide, and PH and adjust ventilation to meet the changing metabolic needs of the body.
Term
central chemoreceptors?
Definition
these are located in the medulla and sense change in blood carbon dioxide. An increase in carbon dioxide levels produce an increase in ventilation that reaches its peek within one minute.
Term
Where are the Peripheral Chemoreceptors located?
What are they and what do they do?
Definition
Carotic artery and aortic bodies, which are found in the bifurcation of the common carotid arteries and in the arch of the aorta, they monitor oxygen levels, they have little control over ventilation until PO2 dips below 60mmmHg.
Term
What are the types of obstructive Pulmonary disorders?
Definition
Bronchil Asthma
COPE
*Emphysem
*chronic Bronchitis
Term
What does COPD stand for and what is it?
Definition
COPD=Chronic obstructive pulmonary disease is one of the most common lung diseases. It makes it difficult to breathe, it’s chronic and recurrent obstruction. It is usually progressive and may be accompanied by hyper-responsiveness and may be partially reversible
Term
There are two main forms of COPD what are they?
Definition
Chronic obstructive bronchitis & Emphysema.
Chronic Obstructive bronchitis is r/t obstruction of small airway and involves a long-term cough with mucus.
Emphysema: is r/t enlargement of air space and involves destruction of the lung tissue over time, you will see loss of lung elasticity.
Term
ARDS:
Definition
Acute Respiratory distress syndrome; life-threatening lung condition that prevents enough oxygen from getting into the blood. This is also listed under stressor to ventiltion and gas exchange.
Term
Neoplasms:
Definition
Lung cancer. An abnormal new growth of tissue that grows by cellular proliferation more rapidly than normal, continues to grow after the stimuli that initiated the new growth cease, shows partial or complete lack of structural organization and functional coordination with the normal tissue, and usually forms a distinct mass of tissue which may be either benign or malignant.
Term
Obstructive disorders are caused by disorders that increase or decrease the resistnce to airflow and all fall under COPD?
Definition
increase the resistance to airflow.
EX: chronic bronchitis, emphysema, COPD, airflow obstruction ans asthma.
Term
Does Bronchial Asthma affect alveoli?
Definition
NO!! It only affects the airways--not the alveoli! Bronchial Asthma is intermittent and recersible airflow obstruction.
Term
What two mechanisms are considered an airway obstruction?
Definition
Inflammation and Hyper-responsiveness.
Inflammation from obsturction of the lumen of the airway.
Hyper-responsiveness- can be triggered by inflammation. it is the constriction of bronchial smooth muscle-> narrowing from outside.
Term
How can inflammation cause airway obstruction?
Definition
The inflammation process produces episodes of airway obstruction, seen as wheezing, breathlessness, chest tightness, and a cough that is worse at night and morning.
Term
Extrinsic Asthma
Definition
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