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Respiratory Physiology
Dr. Olson Autumn 2010
42
Veterinary Medicine
Professional
10/11/2010

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Cards

Term
Hypoxia Definition
Definition
Abnormally low oxygen in blood, tissues, and or lungs. Leads to decreased organ function and/or cellular damage
Term
Hypoxemia Definition
Definition
Insufficient blood oxygen levels to meet metabolic requirements
Term
3 Goals of respiratory adjustment as a response to hypoxemia
Definition
Improve oxygenation
Assist in CO2 removal
Improve oxygen delivery to tissues
Term
4 compensatory signs of respiratory distress
Definition
Increased ventilatory drive
Increased work of breathing
Increased cardiac rate
Increased cardiac contractility
Term
7 possible signs of ventilatory failure
Definition
Use of accessory muscles, intercostal retraction, cyanosis, paradoxical respiration, tachycardia, narcosis, coma
Term
Cyanosis definition
Definition
Bluish-purplish color in the tissues due to an increased amount of deoxygenated hemoglobin
Term
What 3 hypoxemic conditions might be difficult to detect cyanosis with?
Definition
Shock (due to vasoconstriction)
CO2 poisoning (MM appear bright red)
Methoglobinemia (MM dark/brownish)
Term
6 causes of hypoxemia
Definition
Inadequate inspired oxygen, Alveolar hypoventilation, ventilation-perfusion mismatch, diffusion impairment, shunt, and abnormal hemoglobin
Term
Which causes of hypoxemia respond to oxygen supplementation?
Definition
Inadequate inspired O2, ventilation perfusion mismatch, diffusion impairment, some shunts,
Term
Which causes of hypoxemia do not respond to oxygen supplementation?
Definition
some shunts,
Term
When does inadequate inspired O2 commonly occur?
Definition
High altitude, anesthetic mistakes
Term
What is alveolar hypoventilation?
Definition
Oxygen flow to the alveoli is decreased
Term
What causes alveolar hypoventilation?
Definition
neuromuscular failure, increased dead space, airway obstruction, primary pulmonary disease, pleural space disorders, severe brain disorders, muscular fatigue, muscular paralysis
Term
What is the most common cause of hypoxemia?
Definition
Ventilation-perfusion mismatch
Term
Where is the V/Q ratio highest? Lowest?
Definition
Top of the lungs, Bottom of the lungs
Term
What is the immediate cause of diffusion impairment?
Definition
Thickened alveolar barrier
Term
What etiologies can cause a diffusion impairment?
Definition
Edema, fibrosis, pneumonia, COPD, Neoplasia
Term
Shunt definition
Definition
Venous blood bypasses oxygenation in lungs and mixes with arteria blood, deceasing PaO2
Term
Examples of shunts
Definition
Collapsed lung lobes, PDA, patent foramen ovale, other ASDs and VSDs
Term
Causes of methemoglobinemia
Definition
methemoglobin reductase deficiencies, oxidizing agents
Term
How should you evaluate airway patency?
Definition
Observing breathing pattern- a non-patent airway= prolonged inspiration with little/no air movement
Term
4 things to do in respiratory crisis (in order of importance)
Definition
Give oxygen, start invasive ventilation measures, catheterize, draw blood
Term
3 signs of paradoxical respiration
Definition
Inward collapse of intercostal spaces
Inward collapse of abdomen
Inward movement of ribs
(all during inspiration)
Term
5 (6?) anatomic locations of respiratory problems
Definition
Upper airways, Lower airways, Pulmonary parenchyma, pleural space, thoracic wall (cardiac?)
Term
Stridor definition
Definition
High pitched inspiratory noise localized to upper airways
Term
Stertor definition
Definition
Snoring/crackling noise associated with the upper airways
Term
Clinical signs of upper airway obstruction
Definition
stridor, stertor, cyanosis, head/neck extension, orthopnea, exercise intolerance, choking, retching, collapse, clawing at face/neck, honking sounds
Term
Orthopnea definition
Definition
Inability to breath in a recumbent position
Term
Clinical sign of lower airway disorders
Definition
forceful expiratory effort
Term
Clinical signs associated with parenchymal disorders
Definition
open mouth breathing, paradoxical resp. cyanosis, nasal flare, coughing, gagging, dyspnea, anxiety, orthopnea, hemoptysis, fever, tachypnea, tachycardia, weakness, depression, anorexia, nasal discharge, panting
Term
What signs are associated with pulmonary parenchymal disorders related to congestive heart failure?
Definition
Crackles, heart murmurs, and arrhythmias
Term
Hemoptysis definition
Definition
Coughing up blood or bloody foam
Term
What defines the pleural space?
Definition
Visceral and parietal pleurae
Term
Why is there normally a small amount of fluid in the pleural cavity?
Definition
Allows for low friction sliding of the pleurae and instantaneous volume changes
Term
What happens if there is a loss of negative pleural pressure?
Definition
The lungs collapse due to elastic recoil
Term
Clinical signs of pleural space disorders
Definition
short shallow breaths, tachypnea, open mouth breathing, cyanosis, dull lung sounds, auscultable fluid line, muffled cardiac sounds, GI sounds
Term
What types of injuries could cause a thoracic wall respiratory disorder?
Definition
rib fractures, flail chest, sucking and penetrating chest wounds, neurologic, muscular, and orthopedic disease of the thorax
Term
Why might thoracic wall disease, parenchymal, and pleural diseases be closely related?
Definition
chest wall injuries can also have pleural effusions, lung contusions, pneumothorax, and hernias associated with them
Term
What are some clinical signs of thoracic wall disorders?
Definition
Signs of resp. distress, cyanosis, increased chest wall movement, segments of ribs that move independently, lack of abdominal/diaphragmatic movement, lack of intercostal muscle movement.
Term
What should serial physical exams assess in patients with respiratory distress?
Definition
respiratory rate & effort, mucous membrane color, auscultation, pulse quality, and capillary refill time
Term
What is the most objective way to measure oxygenation and ventilation?
Definition
Arterial blood gas analysis
Term
Besides arterial blood gases, what are other ways to monitor ventilation?
Definition
Pulse oximetry and end-tidal CO2
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