Term
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Definition
| the restoration of tissue architecture and function after an injury |
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Term
1) regeneration
2) healing(scar formation) |
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Definition
| the two ways in which repair occurs |
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Term
regeneration
(requires intact CT scaffolding) |
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Definition
the restitution of tissue components identical to those removed or killed(as it was before)
aka growth of tissues and cells to replace lost structures |
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Term
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Definition
| the fibroproliferative response that patches, rather than restores a tissue (=fibrosis, fibrous scar) |
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Term
1)the tissue is intrinsically unable to regenerate(heart)
2)following extensive exudates(organization) ex: inflammatory exudate, pericarditis
3) the underlying CT scaffolding is disrupted/destroyed |
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Definition
| what are the 3 conditions in which fibrosis occurs? |
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Term
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Definition
| what is the clinical consequence of organization? |
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Term
1) framework for cell migration
2) maintain cell polarity for reassembly of multilayer structures
3) cells in the ECM are the source of molecules needed for tissue repair |
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Definition
| what is the ECM scaffold used for? |
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Term
| an apoptotic hepatocyte: following acute hepatitis like yellow fever |
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Definition
| what/where is a councilman body? |
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Term
1) cell proliferation
2) differentiation
3) ECM deposition |
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Definition
| the (3) processes involved in repair |
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Term
-remnants of injured tissue
-vascular endothelial cells
-fibroblasts |
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Definition
| list some of the cell types that proliferate during tissue repair |
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Term
|
Definition
| physiologic tissue proliferaiton vs pathologic = |
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Term
| cyclins(cyclin D)/cyclin dependent kinases(cdk4) |
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Definition
| name the molecules that regulate the cell cycle |
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Term
RB (binds to E2F)
also TP53 ('guardian of the genome' increases as DNA mutations increase. Stops cells at G1 checkpoint) |
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Definition
| list the tumor suppressor genes |
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Term
BAX = apoptosis gene
BCL2 = anti apoptosis gene
Caspases = molecules that carry out apoptosis |
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Definition
| list the apoptosis genes (that are activated when DNA unrepairable) |
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Term
1) labile (continuously dividing tissues ex: skin/mucosa)
2) quiescent (stable tissues ex: liver)
3) non-dividing (permanant tissues) |
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Definition
| 3 groups tissues are divided into based on their proliferative capacity |
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Term
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Definition
| the most common forms of cancer arise from ______ tissues |
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Term
1) epidermis
2) bronchial mucosa
3) oral mucosa
4) cervical mucosa
5) hematopoeitic tissue |
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Definition
|
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Term
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Definition
| labile cells are derived from the division of ___ cells |
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Term
|
Definition
| labile tissues can readily regenerate after injury as long as the pool of _____ are preserved |
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