Term
Urinary Tract Infection:
General |
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Definition
Very large cost to the health care system.
#1 nosocomial infx (30% of total)
#1 community acquired infx
50% of women are >60yo |
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Term
Urinary Tract Infection:
Characteristics |
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Definition
Primarily a female population concern
80% considered to be "uncomplicated" with E.coli as offending bacteria.
10% caused by G+ staph species (Staph a. rising quickly)
Season patterns - patterns specific to individual communities
Elderly have high mortality rate assoc. w/UTIs
When males get UTI → r/t structural abnormality
23% of women have no symptoms |
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Term
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Definition
Asymptomatic presence of bacteria - does not mean infx.
20% of female population at any given time.
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Term
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Definition
1st stage of noticeable bladder infx - Typically mild to moderate - easily treated, often self resolving. (30% have renal tissue involvement with no s/s = caution!)
Onset 24-48 hours post inoculation
Dysuria, pyuria, frequency. Maybe low grade temp. |
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Term
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Definition
Infx of the renal tissue.
Acute or chronic - if chronic → could it cause permanent damage?
Need for aggressive Tx - often IV antibx needed x48 hours followed by oral course 7-10 days
E.coli 80% of the time |
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Term
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Definition
Un/complicated - applies to all locations of UTIs. "Complicated" indicates a co-morbidity. Diabetes or obstructions are largest concern!
"Complicated" = less predictable: E.coli most common. Staph a., Pseudomonas, Klebsiella, Candida.
"Complicated" = full Tx regime: Bactrim, Septra #1 drug. Cipro, Levaquin backups. |
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Term
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Definition
Controls symptoms w/i 3-5 days.
Broad spectrum bacteriocidal. Inhibits DNA production.
Does NOT cross BBB.
Very high degree solubility.
Caution with tendon in pts. ↓ 18 yo
AAPC - Antibiotic Associated Pseudomembranous Colitis |
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Term
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Definition
Broad spectrum bacteriostatic.
↓ Folic acid production → ↓RNA/DNA
High degree of solubility = high concentration in urine.
AE: Hypersensitivity, blood dyscrasias, urine crystal formation. Drug interact: coumadin, oral hypoglycemic agents, cross sensitivity w/Lasix and thiazides |
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Term
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Definition
Broad spectrum bacteriocidal/bacteriostatic.
↓ folic acid production → ↓ RNA/DNA.
High degree of solubility.
AE: GI tract, N/V, itching, rash, blood dyscrasias, anemia, neutropenia, thrombocytopenia. |
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