Term
| Cortical/superficial Nephron |
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Definition
1. Loop of Henle does not dip far
2. Renal corpuscle in Renal Cortex
3. Low Filtration Rate |
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Term
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Definition
1. Long loop of Henle
2. Renal Corpuscle in cortico medullary Junction
3. High Filtration Rate
4. Vasa recta
More of these = more water retention |
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Term
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Definition
| Capillary Beds near loops of Henle that help in Concentrating or Diluting Urine |
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Term
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Definition
| matrix protein of glomulurus that stops plasma protein filtration |
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Term
| Juxtaglomerular Apparatus |
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Definition
1. Macula Densa cells
2. renin producing cells
3. extra glomerular cells-mesangial cells (modified smooth muscle) |
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Term
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Definition
| secrete renin into afferent arterioles |
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Term
| Proximal convoluted tubule |
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Definition
-site of most Na active transport because of large mitochondrial number supplying E.
Na/K ATPase creates gradient for
-Na/H antiport
-Na/Glucose symporter
-Na/AA symporter |
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Term
| Thin Ascending Limp of Henle's Loop |
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Definition
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Term
| Thick Ascending Limb of Henel's Loop |
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Definition
-Not permeable to Water
-Diluting Segment
-Symport of Na, Cl, K
Paracellular transport:
Na K Ca Mg |
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Term
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Definition
Inhibits Na reabsorption in Loop of Henle
leading to
excretion of water and Na |
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Term
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Definition
Na and Cl reabsorption
Not permeable to water |
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Term
| Distal Convoluted Tubule & Collecting Duct |
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Definition
| Location of Principal Cells and Intercalated Cells |
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Term
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Definition
ENac channel
Na & Water absorption |
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Term
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Definition
ENac inhibitor in Principal Cells
-potassium sparing diuretic
-Na reabsorption inhibited ->less negative potential in Lumen -> potassium (+) is not driven into lumen -> saved in system
With ADH (vasopressin) -> water absorption |
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Term
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Definition
Acid/Base Balance
H/K ATPase |
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Term
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Definition
-Excreted during Low blood pressure
-Induces cleavage of Angiotensin I to Angiotensin II
-Constriction of Renal Arterioles |
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Term
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Definition
| Inhibitor of CA in proximal tubule |
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Term
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Definition
| Inhibitor of Na, K, Cl cotransporter in Thick ascending limb |
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Term
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Definition
| Distal convoluted tubule inhibitor of Na, Cl |
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Term
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Definition
| ENac channel inhibitor. K saving. Diuretic |
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Term
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Definition
Major Stimulus: increased renin
Nephron Site: PT
Effect on Transport: increased NaCl & Water reabsorption |
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Term
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Definition
Major Stimulus: Increased Angiotensin II & Plasma K
Nephron Site: TAL, DT/CD
Effect: Increased NaCl & Water Reabsorption |
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Term
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Definition
Major Stimulus: Increased BP & ECV
Nephron Site: CD
Effect: Decreased water & NaCl reabsorption |
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Term
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Definition
Major Stimulus: decreased ECV
Nephron Site: PT, TAL, DT/CD
Effect: increased NaCl & water reabsorption |
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Term
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Definition
Major Stimulus: Increased ECV
Nephron Site: PT
Effect: Decreased water & NaCl reabsorption |
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Term
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Definition
Major Stimulus: increased plasma osmolality, decreased ECV
Nephron Site: DT/CD
Effect: Increased water reabsorption |
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