Term
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Definition
Monocytes, macrophages
DCs
Langerhans
B cells |
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Term
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Definition
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Term
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Definition
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Term
| What happens if an APC encounters a foreign Ag? |
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Definition
Phagocytosis, process
APC MHCII presents the processed Ag to Th0
Th0 CD3 aids in intracellular signal transduction to activate the Th0 cell
Th0's TCR binds to this MHCII/Ag complex |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Activating Th2, B-cells, plasma cells |
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Term
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Definition
| IL 2: T-cell proliferation and inc. production of IL 2 |
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Term
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Definition
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Term
| IFN-gamma and TNF-beta's function is... |
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Definition
| Activating macrophages, CTLs, and NK cells |
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Term
| Macrophages, CTLs, and NK cells provide cellular immunity by directly... |
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Definition
| Attacking and destroying bacteria, virus-infected cells, and tumor cells |
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Term
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Definition
IL 2
IL 4
IL 5
IL 6
IL 10
All stim. B-cell proliferation |
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Term
| Th2 cells aid in which kind of immunity? |
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Definition
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Term
| Describe the sequence of steps in allograft rejection |
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Definition
1. Interstitial DCs w/ foreign MHCII in transplanted tissue
2. Foreign MHCII directly stimulate recipient Th0s
3. Th1s secrete IFN-gamma and TNF-beta, which inc. expression of endothelium adhesion molecules = easier for leukocytes to invade the graft
4. IFN-gamma induces graft cells to express MHCII, which provides more Ab "targets" and inc. stimulation of recipient's immune system
5. Anti-donorMHCII-Ab activate complement, inflamm, plt activation, hemorrhage, thrombosis |
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Term
| Prednisone and (active metabolite) prednisolone: leukocytopenia |
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Definition
1. Lymphocytopenia
2. Dec. monocytes
3. Dec. eosinophils and basophils
4. Inc. neutrophils b/c BM releases more and they marginate less |
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Term
| Prednisone/prednisolone: general effects |
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Definition
1. Leukocytopenia
2. Interference w/ macrophage fxn
3. Interference w/ T-cell fxn
4. Interference w/ IL synthesis |
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Term
| Prednisone/prednisolone: lymphoid tissue |
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Definition
| Dec. in lymph nodes and spleen |
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Term
| Prednisone/prednisolone: IL synthesis |
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Definition
Blocks:
IL 1,2,4,6
IFN-gamma
TNF-beta |
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Term
| Prednisone/prednisolone: random other stuff it does |
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Definition
Dec. activation of Th1
Dec. the inc. MHCII and adhesion molecule expression on the graft |
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Term
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Definition
Binds to cytoplasmic cyclophilin
Cyclosporine-philin complex inhibits calcineurin
Can't dephosphorylate nuclear factor of activated T cells (NFATC)
NFATC can't travel to nucleus and activate genes for IL 2, IL 2R, IFN-gamma, TNF-beta |
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Term
| Cyclosporine: random other stuff it does |
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Definition
| Prevents B-cell proliferation |
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Term
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Definition
Binds to cytosolic protein FKBP in Th cells
Tacrolimus-FKBP complex inhibits calcineurin
Can't dephosphorylate nuclear factor of activated T cells (NFATC)
NFATC can't travel to nucleus and activate genes for IL 2, IL 2R, IFN-gamma, TNF-beta |
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Term
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Definition
Inhibits inosine monophosphate dehydrogenase in lymphocytes
Can't synthesize guanine de novo
Lymphocytes don't have an alternative pathway (like HGRPT) to make guanine |
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Term
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Definition
Anti-CD3-Ab
Blocks TCR binding to MHCII-Ag complex
Th, CTL fxns blocked
No production of ILs and TCR endocytoses
Anergy and removed from circulation by RE system |
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