Term
| What are the drawbacks of creatinine estimating GFR |
|
Definition
Overestimation
Steady State
Variation in Size, Sex, Age, Ethnicity |
|
|
Term
|
Definition
Diabetes 50%
HPTN 35%
GN or Tubulointerstitial
Hereditary
Vasculitities
Idiopathic |
|
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Term
|
Definition
1) >90 Damage w/o GFR loss
2) 60-89 Damage w/ decrease GFR
3) 30-59 Moderate
4) 15-29 Severe
5) <15 End-Stage |
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Term
| How do you slow the progression of Renal disfunction |
|
Definition
Tx Underlying Disease
Tx Co-morbidities
Tx CV Diseases
RAAS Blockage
Tx HPTN
Avoid Obesity and Nephrotoxins |
|
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Term
| What is the adaptation of the kidney to injury |
|
Definition
Increased production of ATNII causing Hyperfiltration
Increases ROS delivery to glomeruli and tubules leading to:
glomerulosclerosis and tubular hypertrophy |
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Term
| What are the names of some equations to estimate GFR? |
|
Definition
Cockroft Gault
MDRD Modification of diet in renal disease |
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|
Term
| What is Crystatin C and how is it used |
|
Definition
Low molecular weight protein produced by all nucleated cells
Used to calculate eGFR independant of muscle mass, sex, ethnicity, and age |
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Term
| What comorbid condition do most patients with a GFR <60ml/min have |
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Definition
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