Term
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Definition
1. carbonic anhydrase inhibitor; alkalize urine + weak diuresis = distally will increase K excretion
2. glaucoma, metabolic alk, get urin alk, Acute Mountain sickness
3. metabolic acidosis, Ca-renal stones, K wasting; Sulfa Allergy; Contra to Cirrhosis bc decr excretion of ammonium |
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Term
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Definition
1. osmotic diuretic, freely filtered
2. give parenterally: decr brain & intraocular pressure
3. first hypoNa and pulm edema, then hyperNa and dehydration |
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Term
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Definition
1. loop diuretic, block Na/K/2Cl pump, excrete Ca/Mg
2. hypercalcemia or kalemia, EDEMA, HTN, anion OD
3. post-diuretic Na-retention; ototoxic, Sulfa rxn
4. Aminoglycosides & ototoxic, NSAIDs & uricosurics blut diuresis; very PRO-bound |
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Term
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Definition
1. loop diuretic, block Na/K/2Cl pump, excrete Ca/Mg
2. hypercalcemia or kalemia, EDEMA, HTN, anion OD
3. post-diuretic Na-retention; ototoxic, Sulfa rxn
4. Aminoglycosides & ototoxic, NSAIDs & uricosurics blut diuresis; very PRO-bound |
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Term
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Definition
1. loop diuretic, block Na/K/2Cl pump, excrete Ca/Mg
2. hypercalcemia or kalemia, EDEMA, HTN, anion OD
3. post-diuretic Na-retention; ototoxic, Sulfa rxn
4. Aminoglycosides & ototoxic, NSAIDs & uricosurics blut diuresis; very PRO-bound |
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Term
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Definition
1. loop diuretic, block Na/K/2Cl pump, excrete Ca/Mg
2. hypercalcemia or kalemia, EDEMA, HTN, anion OD, No Sulfa Rxn!
3. post-diuretic Na-retention; ototoxic
4. Aminoglycosides & ototoxic, NSAIDs & uricosurics blut diuresis; very PRO-bound |
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Term
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Definition
1. distal tube diuretic, block Na/Cl cotransporter & ENHANCE Ca-reabsorption, secreted via OAT proximally
2. HTN, edema, nephrogenic DI, Nephrolithiasis from hyperCa-uric; Osteoporosis
3. hypoK or Na, hyperuricemia, Sulfa Rxn, hyperglycemia/lipidemia
4. AmphoB; NSAIDs & uricosurics blut diuresis |
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Term
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Definition
1. distal tube diuretic, block Na/Cl cotransporter & ENHANCE Ca-reabsorption, secreted via OAT proximally
2. HTN, edema, nephrogenic DI, Nephrolithiasis from hyperCa-uric; Osteoporosis
3. hypoK or Na, hyperuricemia, Sulfa Rxn, hyperglycemia/lipidemia
4. AmphoB; NSAIDs & uricosurics blut diuresis |
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Term
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Definition
1. distal tube diuretic, block Na/Cl cotransporter & ENHANCE Ca-reabsorption, secreted via OAT proximally
2. HTN, edema, nephrogenic DI, Nephrolithiasis from hyperCa-uric; Osteoporosis
3. hypoK or Na, hyperuricemia, Sulfa Rxn, hyperglycemia/lipidemia
4. AmphoB; NSAIDs & uricosurics blut diuresis |
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Term
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Definition
1. K-sparing diuretic, CCD ENaC inhibitor
2. combo tx; less risk of hypoK metabolic alkalosis
3. hyperCl metabolic alk |
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Term
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Definition
1. K-sparing diuretic, CCD ENaC inhibitor
2. combo tx; less risk of hypoK metabolic alkalosis
3. ARF (esp+ indomethacin), Kidney Stones, hyperCl metabolic alk |
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Term
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Definition
1. K-sparing; basolateral aldosterone R antagonist = decr Na in and decr K/H out
2. HF, CIRRHOSIS edema, hyperAldo, mineralcorticoid excess
3. Gynecomastia, impotence from overlap at androgen/progest-R; hyperCl metabolic alk |
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Term
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Definition
1. K-sparing; basolateral aldosterone R antagonist = decr Na in and decr K/H out; more Mineral-R selective
2. hyperAldo, mineralcorticoid excess
3. hyperCl metabolic alk |
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Term
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Definition
1. synthetic vasopressin V2-selective agonist = no vasoconstriction!
(longer 1/2life than endogenous)
2. central DI, coagulopathies of Hemoph A and vWB disease
3. hypoNa
4. lithium = block insertion of aquaporins |
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Term
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Definition
1. vasopressin V1 & V2 antagonist
(lithium would have same effect, tho less predictable)
2. SIADH, CHF
3. HyperNa, nephrogenic DI, ARF
4. lithium
3. many side effects |
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Term
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Definition
1. vasopressin V1 & V2 antagonist
(lithium would have same effect, tho less predictable)
2. SIADH, CHF
3. HyperNa, nephrogenic DI, ARF
4. lithium
3. many side effects |
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Term
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Definition
1. renin inhibitor; very complete RAAS block w/o incr in bradykinin
2. ACE-i induced cough HTN-pts; great with thiazide |
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Term
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Definition
1. inhibit L-type voltage gated Ca++ channels of vascular and cardiac m. = decr PVR
2. HTN
3. AV block, bradycardia, worsen CHF |
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Term
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Definition
1. inhibit L-type voltage gated Ca++ channels of vascular and cardiac m.
2. HTN
3. AV block, bradycardia |
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Term
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Definition
1. inhibit L-type voltage gated Ca++ channels, but more vaso-selective and much less cardiac effects
2. HTN
3. Ankle Edema, tinnitus |
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Term
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Definition
1. ACE-inhibitor; also blunts Aldo release & is K-sparing
2. HTN with HF/CAD/Chronic renal
3. dry cough and angioedema due to incr bradykinin; Keep watch on RENAL fx; Teratogen
exception - NOT used with renal artery stenosis |
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Term
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Definition
1. AngioII-R type1 competitive inhibitor (also blocks Chymase-tissue ACE)
2. no bradykinin cough, less angioedema
3. teratogen, ARF |
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