Term
Enalapril (pril)
ACE Inhibitor |
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Definition
Cough; Increases levels of bradykinin; hypotension; hyperkalaemia |
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Term
Isosartan (sartans)
Angiotensin receptor blocker |
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Definition
Cough; Increases levels of bradykinin; hypotension (less than ACEI) hyperkalaemia |
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Term
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Definition
Bronchoconstriction, bradycardia, AV block, depression, sedation, exacerbate diabetes and mask hypoglycaemia, impotence |
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Term
Verapamil
Ca channel blocker |
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Definition
Cardiac depression, bradycardia, dizziness, constipation, nausea, headache |
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Term
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Definition
Transient expansion, headache, nausea, vomiting |
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Term
Acetazolamide
Carbonic anhydrase inhibitor |
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Definition
Metabolic acidosis, renal stones, renal K+ loss |
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Term
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Definition
Electrolyte imbalance, K+ loss, impotence, hyperuricaemia, glucose intolerance, hypovolaemia, hearing loss, increased Ca and Mg excretion |
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Term
Chlorothiazide, hydrochlorothiazide
Thiazide diuretics |
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Definition
K+ loss, rash, hyperuricaemia, hypercholesterolaemia, glucose intolernace |
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Term
Spironolactone
Aldosterone receptor antagonist (K+ sparring diuretic) |
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Definition
Hyperkalaemia, decreased labido, impotence, menstrual disturbances |
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Term
Amiloride, triamterene
Na+ channel blockers (K+ sparing diuretics) |
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Definition
Hyperkalaemia, hyperuricaemia, minor SEs |
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Term
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Definition
Agranulocytosis, cross placenta and milk, rashes, headache, nausea, joint pains |
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Term
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Definition
Possible allergic reactions |
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Term
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Definition
Hypothyroidism, thyroid cancer (small increase in risk) |
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Term
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Definition
Elderly at risk of angina, arrhythmia, heart failure; osteoporosis |
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Term
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Definition
Hypercalcaemia, hypercalciuria |
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Term
Hormone replacement therapy |
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Definition
Increased risk of cancers (eg breast), adverse cardiovascular effects |
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Term
Raloxifene
Selective estrogen receptor modulator (SERM) |
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Definition
May affect breast and endometrial tissue, adverse cardiovascular effects |
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Term
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Definition
Osteonecrosis of jaw, effect limited after 5 years, GI effects, compliance issues, atypical freactures |
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Term
Densumab
Monoclonal antibody against RANKL |
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Definition
Lacks long term safety and efficacy data |
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Term
Teriparatide
PTH/PTH fragments, bone anabolic agent |
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Definition
Possible increase in osteosarcoma |
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Term
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Definition
Hypoglycaemia, formation of antibodies, local allergic reactions |
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Term
Metformin
Insulin sensitiser |
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Definition
Weight loss, nausea, diarrhoea |
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Term
Thiazolidinediones
TZDs/glitazones Insulin sensitiser |
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Definition
Weight gain, long term safety still unsure |
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Term
Glicazide
Sulphonylureas Insulin secretion |
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Definition
High protein binding, hypoglycaemia, weight gain (stimulate appetite) |
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Term
Repaglinide
Glitinides Insulin secretion |
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Definition
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Term
Acarbose a-glucosidase inhibitors
Oral hypoglycaemic agent |
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Definition
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