Term
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Definition
outer cortex --> B-cells, follicles
inner cortex = paracortex --> T-cells, endothelial venules (cells come out!)
medulla --> plasma cells, macrophages |
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Term
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Definition
| central artery --> WHITE PULP: [periarterial lymphatic sheath (T-cells) --> follicles (B-cells)] --> marginal zone (macrophages, APCs) --> RED PULP: [splenic cords (type III collagen) --> splenic sinuses (gotta crawl in!! -- filter!!)] |
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Term
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Definition
| RA + splenomegaly + neutropenia |
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Term
| "sugar-coated" capsule, Gandy-Gamma nodules |
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Definition
congestive splenomegaly
Gandy-Gamma nodules (fibrosis, Fe, Ca) |
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Term
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Definition
cortex -- blood-thymus barrier!! -- thymocytes (immature) + nurse cells (thymic epitheliocytes -- positive selection)
junction -- thymic dendritic cells (negative selection)
medulla -- mature T cells, Hassell's corpuscles (whorls of keratinized epitheliocytes) |
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Term
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Definition
activated by IL-12
secretes IL-2, IL-3, IFN-gamma
inhibited by IL-10 |
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Term
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Definition
activated by IL-4
secretes IL-3, IL-4, IL-5, IL-6, IL-10
inhibited by IFN-gamma |
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Term
| cell activation: Th, Tc, B cell |
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Definition
Th: MHCII+TCR; B7(APC)+CD28(Th)
Tc: MHCI+TCR; IL-2(Th1)+IL-2R(Tc)
B cell: CD40L(Th2)+CD40(B); cytokines |
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Term
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Definition
| CD3, CD4, CD25 (low affinity IL-2 receptor) |
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Term
| where complement and stuff bind on Ig |
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Definition
complement -- CH2 (right by hinge)
other stuff -- CH3 (bottom via FcR) |
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Term
| Ig which end is N vs. C terminal? |
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Definition
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Term
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Definition
1. random recomination -- combinatorial
2. somatic hypermutation -- after stimulation, random mutation, keep ones that bind the best
3. addition of nucleotides during recomb (Tdt) -- junctional diversity |
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Term
| circulatory vs. secretory IgA |
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Definition
circulatory -- monomer
secretory -- dimer (secretory component from epithelial cells) |
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Term
| antigen receptor on B cell |
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Definition
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Term
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Definition
| no peptide --> no T cells (thymus-independent) --> only IgM and no memory!! |
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Term
| why no spleen --> susceptible to encapsulated bacteria |
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Definition
| less IgM --> less C' --> less C3b --> susceptibility to encapsulated organisms |
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Term
| C1 esterase inhibitor deficiency |
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Definition
hereditary angioedema
no ACEi!! |
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Term
|
Definition
pyogenic sinus and respiratory tract infections
more type III hypersensitivity reactions (C3 helps clear ICs!!!!) |
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Term
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Definition
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Term
|
Definition
| IgG and IgM (GM makes classic cars!!) |
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Term
| cytokines secreted by macrophages |
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Definition
| IL-1, IL-6, IL-8, IL-12, TNF-alpha |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
|
Definition
differentiation into Th1
activates NK cells |
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Term
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Definition
septic shock
F, acute phase reactant |
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Term
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Definition
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Term
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Definition
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Term
|
Definition
activates macrophages, Th1
suppresses Th2
increase MHCI and II and antigen presentation in all cells |
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Term
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Definition
inhibit viral protein synthesis and replication
activates NK cells |
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Term
|
Definition
induce differention into Th2
class switch to IgE and IgG |
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Term
|
Definition
class switch to IgA
recruit eosinophils |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
| macrophages (where LPS binds!!!) |
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Term
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Definition
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Term
|
Definition
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Term
|
Definition
|
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Term
| when to give passive immunity |
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Definition
To Be Healed Rapidly
Tetanus
Botulism
Hep B
Rabies |
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Term
| marker of mast cell degradulation |
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Definition
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Term
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Definition
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Term
|
Definition
IgM, IgG
1) opsonize cell OR activate C'
2) recruit neutrophils, macrophages
3) bind normal cells and change functioning |
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Term
| type III hypersensitivity |
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Definition
| IgG complexes --> activate C' --> attract neutrophils --> release lysosomal enzymes |
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Term
| serum sickness -- esp when it happens! |
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Definition
type III
F, urticaria, arthralgias, proteinuria, LAD 5-10 days!!! |
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Term
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Definition
type III
local, following intradermal injection (i.e. immunization!!) --> local edema, necrosis, C' |
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Term
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Definition
| T cells --> activate macrophages |
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Term
which kind of hypersensitivity??
SLE |
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Definition
| III (think of the kidneys!!) |
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Term
which kind of hypersensitivity??
RA |
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Definition
|
|
Term
which kind of hypersensitivity??
PAN |
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Definition
|
|
Term
which kind of hypersensitivity??
hypersensitivity pneumonitis |
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Definition
|
|
Term
which kind of hypersensitivity??
DMI |
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Definition
|
|
Term
which kind of hypersensitivity??
MS |
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Definition
|
|
Term
which kind of hypersensitivity??
GBS |
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Definition
|
|
Term
which kind of hypersensitivity??
Hashimoto's thyroiditis |
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Definition
|
|
Term
which kind of hypersensitivity??
contact dermatitis |
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Definition
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|
Term
blood reaction:
allergic reaction |
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Definition
| type I, against plasma protein |
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Term
blood reaction:
febrile non-hemolytic transfusion reaction |
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Definition
| type II, Ab against donor HLA antigens and WBCs |
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Term
blood reaction:
acute hemolytic transfusion reaction |
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Definition
| type II, pre-formed antibodies to ABO (intravasc hemolysis), antigen on foreign RBC (extravasc hemolysis) |
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Term
|
Definition
bacteria -- sepsis
viruses -- CMB, EBV, VZV, chronic resp/GI viruses
fungi/parasites -- Candida (superficial!!), PCP |
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Term
|
Definition
bacteria -- encapsulated
viruses -- enteroviral (no IgA!!)
fungi/parasites -- Giardia (no IgA!!) |
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Term
|
Definition
bacteria -- Staph, Pseudomonas
Fungi/parasites -- Candida (disseminated!!), Aspergillus |
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Term
|
Definition
Bruton's -- BTK defect (tyrosine kinase) --> blocks formation of immature B-cells --> decreased B cells
hyper-IgM -- defective CD40L --> can't class switch --> high IgM, low everything else
IgA def
common variable immunodef -- acquired defect in B cell maturation --> normal number B cells, low plasma cells, low Igs |
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Term
|
Definition
DiGeorge -- CATCH 22, no thymic shadow
Job's -- failure to prod IFN-gamma; FATED
chronic mucocutaneous candidiasis -- T cell dysfunction
IL-12R def -- decreased Th1 response --> mycobacterial infections, low IFN-gamma |
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Term
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Definition
SCID -- IL-2R defect; adenosine deaminase --> high dATP inhibits ribonucleotide reductase, high adenosine toxic to B/T cells; failure to make MHC II
ataxia-telangiectasia -- ATM defect (DNA repair of non-homologous end joining); low IgA
Wisckott-Aldrich -- X-linked; progressive deletion of B/T cells; TIE; low IgM, high IgE/IgA |
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Term
|
Definition
leukocyte adhesion def -- LFA-1 integrin (type 1), Sialyl Lewis (type 2); no pus, delayed umbilical separation, neutrophilia
Chediak-Higashi syndrome -- defect in lysosomal regulator trafficking gene (LYST) --> MT dysfx in phagosome-lysosome fusion; staph/strep, partial albinism, peripheral neuropathy; large cytoplasmic granules (lysosomes!!)
CGD -- lack NADPH oxidase; catalase + infections; negative Nitroblue!! |
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Term
|
Definition
hyperacute -- min -- preformed anti-donor Ab (type II) --> occludes vessels --> ischemia/necrosis with neutrophils
acute -- wks -- graft MHC is "foreign"; vasculitis with lymphocytes
chronic -- mo-yrs -- graft MHC + self antigen is "foreign"; T-cell AND Ab --> obliterative vasc fibrosis (EXCEPT lungs -- bronchiolitis obliterans)
GVH -- donor T cells activated; rash, jaundice/HSM, diarrhea |
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