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Damages living systems by ionizing the atoms compromising the molecular structures of the systems. |
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Three characteristics of ionizing radiation are: |
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The average energy deposited per unit length of track. |
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streams of particles called photons, each of which has no mass and no charge. |
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Examples of low LET radiation |
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Examples of High-Let Radiation |
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- Alpha particles,
- Ions of heavy molecules,
- Charges particles released from interactions between neutrons and atoms,
- low-energy neutrons
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High- Let radiation includes particles that possess substantial: |
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a type of white cell play an important roll in fighting infection. |
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Permanent sterilization occurs at |
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where are lymphocytes manufactured in the human body? |
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Examples of distorted chromosomes: |
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- Anaphase bridge
- Dicentric chromosomes
- Ring chromosomes
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Radiosensitivity of the individual cell |
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governs the radiation dose required to cause apoptosis. |
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3 levels of radiation damage: |
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- Molecular
- cellular
- organic systems
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Oxygen enhancement ratio (OER) |
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the ratio of the radiation dose required to cause a particular biologic response of cells or organisms in an oxygen-deprived environment to the radiation dose required to cause an identical response under normal oxygenated conditions. |
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In living system, biologic damage stemming from exposure to ionizing radiation is observed on three levels: |
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- Molecular
- Cellular
- Organic systems
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- Alteration of a chemical involved in mitosis
- Proteins required for cell division not being synthesized
- A change in the rate of DNA synthesis after irradiation
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- Basal cells of the skin
- Blood cells such as lymphocytes and erythrocytes
- intestinal crypt cells
- Reproductive (germ) cells
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As the ___ of radiation increases, so do biologic effects. |
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is relatively insensitive to radiation. |
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Most radiosensitive blood cells |
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