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Radiobiology
Radiobiology Mod 3
20
Health Care
Undergraduate 2
08/28/2021

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Term
Structural proteins
Definition
The body acquires its shape and form from these proteins. Also a source of heat and energy.
Term
Linear energy transfer
Definition
LET: is the amount of energy transferred on average by incident radiation to an object per unit length of track
Term
RBE
Definition
Relative Biologic Effectiveness:
is used to describe the capabilities of radiation with different linear energy transfers to produce a particular biologic reaction
Term
The three levels of biological damage
Definition
Molecular
Cellular
Organic
Term
Ionizing radiation
Definition
radiation with sufficient energy to cause ionization in the medium through which it is penetrating
Term
Apoptosis
Definition
cell death that occurs when cells die without attempting division during the interphase portion of the cell life cycle
Term
Cell survival:
What happens when the dose is increased
Definition
An increase in dose will decrease the survival
Term
Law of Bergonie and Tribendeau
Definition
states that the radiosensitivity of cells is directly proportional to their reproductive activity and inversely proportional to their degree of differentiation
Term
Examples of highly radiosensitive tissue
Definition
Gonads
Bone marrow
Embryonic tissue
Term
Examples of moderately radiosensitive tissue
Definition
Lens
Liver
Skin
Term
Examples of low radiosensitive tissue
Definition
Muscle
Connective tissue
Central nervous system
Term
Direct action
Definition
Caused by compton scattering and photoelectric effect.
Ionization of atoms that cause absorption
Term
Indirect action
Definition
Caused by free radicals that are created by radiation interacting with water
Term
Single-strand break
Definition
Ionizing radiation interacts with DNA macromolecule, transfers energy, and ruptures one of the molecule’s chemical bonds possibly severing one of the sugar-phosphate chain side rails.
Term
Double-strand break
Definition
Further exposure of the affected DNA macromolecule to ionizing radiation can lead to additional breaks in the sugar-phosphate molecular chain.
Term
What are the four subphases of mitosis
Definition
Prophase
Metaphase
Anaphase
Telophase
Term
What is mitosis
Definition
when the nucleus first divides, followed by the division of the cytoplasm
Term
Oxygen enhancement ratio
Definition
When irradiated in an oxygenated state, biologic tissue is more sensitive to radiation than when it is exposed to radiation under anoxic low or no oxygen
Term
What is meiosis
Definition
cell division that reduces the number of chromosomes in each daughter cell to half the number of chromosomes in the parent cell
Term
Two effects of ionizing radiation on DNA
Definition
Single-strand break
Double-strand break
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