Term
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Pacil)
Citalopram (Celexa)
Escitalopraom (Lexapro) |
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Definition
SSRIs
MECH: Prevent re-uptake of serotonin
USE: 1st line in depression
SE: Sexual dysfxn; anorexia; serotonin syndrome
NOTES: Not for use with MAOIs --> Serotonin syndrome |
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Term
Imapramine
Amitriptyline
Trimimipramine
Nortiptyline
Desipramine
Clomipramine
Dexepin |
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Definition
Tricyclic Antidepressants
MECH: Inhibits reuptake of NE & serotonin to increase availability in synaptic cleft
USE: Tx depression, but NOT 1st line
SE: Arrhythmia; antihistaminic; antiadrenergic; antimuscarinic
NOTES: Not with pts with existing conduction problem; Tx OD with sodium HCO3- |
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Term
Phenelzine
Tanylcypromine
Isocarboxazid |
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Definition
MAOIs
MECH: Prevent activation of NE, serotonin, DA; MAO-A for serotonin; MAO-B for NE
USE: Refractory depression; NOT 1st line
SE: Orthostatic HTN; hypertensive crisis; serotonin syndrome
NOTES: Avoid tyramine-foods --> hypertensive crisis |
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Term
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Definition
SNRI
MECH: Serotonin and NE reuptake inhibition
SE: Increased BP; sexual dysfxn; anorexia |
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Term
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Definition
NDRI
MECH: NE and DA reuptake inhibition
SE: Lowers seizure threshold
NOTES: Not for pts with seizure disorders, eating disorders or on MAOIs |
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Term
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Definition
NARIs
MECH: NE and serotonin agonist
NOTES: Useful in malnourished or have sleep problems |
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Term
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Definition
SARIs
MECH: Inhibits prevention of serotonin reuptake
USE: Sleeping aid when used at lower doses
SE: Arrhythmias; priapism |
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