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Pulmonary Mechanics
Gas Physics/Physiology
24
Medical
Graduate
10/23/2010

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Cards

Term
What is external respiration?
Definition
*Everything outside the body up until gas enters the blood stream through the lungs
Term
What is internal respiration?
Definition
*Gas going to blood stream for cells to make ATP
Term
What is the goal of respiration?
Definition

*To make ATP for using energy from phosphate bonds

*Occurs d/t krebs (citric acid cycle) or oxidative (B-oxidation) phosphorylation

Term
What is dalton's law?
Definition

*The sum of the individual gases in the container = the total pressure in the system

*Force is applied when molecule bounces off wall

*Every force has a magnitude (amount) and a vector (direction)

Term
How much in mmHg is 1 atmosphere or the pressure at "Miami beach" or sea level?
Definition
*760mmHg
Term
Why can warmer hair "hold" more water?
Definition

*Molecules are moving faster and offers a greater opportunity for molecules to get in and more space available

*Warmer = more energy for water to leave liquid state to gaseous state

Term
Pressure= ?/?
Definition
*Force/Volume
Term
How much oxygen can you dissolve in 100mL of blood?
Definition
*Solubility: 0.003mL O2/ (100mL blood/1mmHg pO2)
Term
What is the pp of water that saturates 37 degrees at 100% humidity?
Definition
*47mmHg
Term
The pO2 must drop from above _____ torr to _____ torr to lose the 1st O2 from Hgb.
Definition

*>100 torr

*40 torr

Term
What is the p50 on the oxyhemoglobin dissociation curve?
Definition
*27mmHg
Term
A decrease in Hgb affects the O2 ___________.
Definition
*Carrying Capacity
Term

What is the PO2 at which blood is:

a. 100% saturated

B. 90% saturated

C. 75% saturated 

D. 50% saturatred

Definition

A. 100 pO2

B. 60 pO2

C. 40pO2

D. 27pO2

Term
When are the 3rd and 4th hgb utilized?
Definition
*When the pO2 is REALLY low- 10-27 torr
Term
A decrease in pH will ______ p50.
Definition
*increase
Term
What is replaced in fetal hemoglobin?
Definition

*B chains, which results in a shift to the left.

*Fetus isn't breathing so circulating maternal blood from the placenta. The low p50 enables infant to be able to bind and extract from blood via diffusion.

Term
What is the approx. saturation in the fetus?
Definition
*~90%
Term
How is CO2 distributed throughout your body?
Definition

*5% is dissolved

*30% Carbamino compounds

*65% Bicarbonate ion 

Term
What CO2 storage method is the primary method for moving CO2 out of the tissue beds and to the lung?
Definition
*Bicarbonate Ion
Term
What does carbonic anhydrase do?
Definition
*Speeds up the formation of H2CO3 from H2O and dCO2
Term
What is HCO3 exchanged with in the RBC?  What is this called?
Definition

*Exchanged with Cl-

*Cl- diffuses into the RBC and causes a negative "chloride shift" or the "hamburger phenomena"

Term
At what level of hemoglobin reduction do you turn blue?
Definition

*Can turn blue with a 5gm/dL reduced Hgb

 

Term
What saturations and hbg does a child, Adult, "DRH patient", and a CRF or Trauma pt turn blue?
Definition

Hgb reduced by 5g/dL

*Child: 20g/dL (normal)- Sat 75%

*Adult: 15g/dL- Sat 66%

*DRH: 10g/dL- Sat 50%

*CRF/Trauma: 5-0 g/dL- Sat will be zero before blue

Term
True or False: Pulse oximetry is a very poor measurement and varies greatly depending on O2 sat
Definition
True
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