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Pulmonary Lecture/Lab 1
Pulmonary Lecture/Lab 1
216
Medical
Graduate
12/04/2015

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Term
4 periods of fetal pulmonary development
Definition
embryonic
pseudoglandular
canalicular
terminal sac
Term
fetal pulmonary develpment: embryonic period duration
Definition
1-4 weeks
Term
fetal pulmonary develpment: embryonic period structures (3)
Definition
larynx
trachea lung buds
bronchia buds
Term
fetal pulmonary develpment: pseudoglandular period duraiton
Definition
5-17 weeks
Term
fetal pulmonary develpment: pseudoglandular period structures (2)
Definition
secondary bronchi
broncho-pulmonary segments
Term
fetal pulmonary develpment: canalicular period duration
Definition
16-25 weeks
terminal and respiratory bronchioles
Term
fetal pulmonary develpment: terminal sac period duration
Definition
26 wks to birth
Term
fetal pulmonary develpment: terminal sac period structures (2)
Definition
pulmonary alveoli
Type II alveolar cells to produce surfactant
Term
fetal pulmonary develpment: which period is the most important? why?
Definition
terminal sac period
period in which Type II alveolar cells which produce surfactant appear
Term
purpose of surfactant
Definition
keeps surface tension on the alveoli keeping them open, otherwise every expiration the alveoli would close
Term
action of birth activity for pulmonary develpment
Definition
pushing fluid out of lungs, expanding alveoli in the first few breaths
Term
improtance of a child crying at birth
Definition
allows for the action of pushing the fluid out to occur
Term
early childhood time frame
Definition
0-4 years up to 7 yrs
Term
structures in early childhood (2)
Definition
increase in # of alveoli
increase in vital capacity
Term
mm of respiration (6)
Definition
diaphragm
SCM
scalenes
upper trap
pec mj
pec mn
Term
primary mm of inspiration
Definition
diaphragm
Term
contraction of the diaphragm does what to the visceral
Definition
pushes them downward
Term
contractino of the diaphragm does what to the lower ribs
Definition
elevates and outwardly expands (bucket-handle action)
Term
which side of the diaphragm will move more
Definition
right side
Term
why will the right side of teh diaphragm move more
Definition
d/t more resistance from abdominal cavity on the right
Term
normal diaphragm excursion at rest
Definition
2 cm
Term
normal diaphragm excursion with full inspiration
Definition
can increase it to 8-10 cm
Term
diaphragm in supine will rest how
Definition
rests high
Term
when in sidelying, which portion will drop to a lower level
Definition
the upper most portion
Term
when in sidelying, which side of the diaphragm has the greatest excursion
Definition
the lower/dependent portion
Term
which side of teh diaphragm will get greater ventilation when in sidelying
Definition
lower/dependent lung
Term
5 accessory mm of respiration
Definition
SCM
scalnes
upper trap
pec mj
pec mn
Term
accessory mm assist in what (3)
Definition
inspiraiton
expiration
role in maintaining posture
Term
relationship between the accessory mm and the ribs
Definition
accessory mm elevate the upper thorax creating the pump handle mvmt pattern for the upper ribs
Term
mvmt of the thoracic cage when the accessory mm contract
Definition
anterior and superior
Term
continuous membranous sacs which cover the lungs
Definition
pleurae
Term
what is the visceral pleura
Definition
surface in contact with the lung
Term
what is the parietal plerua
Definition
ourter portion of pleural sac
Term
what is the pleural space
Definition
space between visceral pleura and parietal plerua
Term
what happens with pleurisy
Definition
pathological inflammatory condition of the pleura in which the pleura becomes inflamed and fills with fluid exudate
Term
Lung contusions and pleurisy both result in what
Definition
pleural effusion
Term
Parts of teh right upper lobe (3)
Definition
Apical
Anterior
Posterior
Term
Parts of the left upper lobe (5)
Definition
Apico-posterior Anterior Posterior Superior Lingula Inferior Lingula
Term
anatomical position of the right apical segment/left apicoposterior segment anteriorly and posterirly
Definition
ant superior to clavicle
post superior to spine of scapula
Term
anatomical position of the right and left anterior segmetns of upper anteriorly and posteriorly
Definition
ant clavicle to 3rd intercostal space or 4th rib
posteriory - trick question
Term
anatomical landmarks of the right and left posterior segmetns of the upper lobe
Definition
spine of scapula to the inferomedial aspect of spine of the scapula
Term
anatomical landmark for the superior border of the lingula
Definition
3rd intercostal space/4th rib
Term
anatomical landmark for inferior border of the lingula
Definition
oblique fissure (6th rib anterior, extending to 4th rib at posterior)
Term
where are the superior and inferior lingular segments divided in terms of anatomical landmarks
Definition
horizonal line at level of 5th rib
Term
anatomical landmarks: superior border of the right middle lobe
Definition
3rd intercostal space/4th rib
Term
anatomical landmarks: inferior border of the right middle lobe
Definition
oblique fissure (6th rib ant extending to 4th rib at post)
Term
anatomical landmarks: where are the medial and lateral segments of the right middle lobe divided
Definition
midclavicular line
Term
4 parts of the lower lobes
Definition
anterior basilar
Lateral basilar
superior basilar
posterior basilar
Term
which parts of the lower lobe can only be seen posteriorly
Definition
superior
po
Term
which parts of the lower lobe have the majority of their structure on the the posterior (3)
Definition
superior basilar
posterior basilar
lateral basilar
Term
anatomical landmarks: superior border of the anterior basilar segment
Definition
oblique fissure
Term
anatomical landmarks: lateral border of the anterior basilar segment
Definition
mid-axillary line
Term
anatomical landmarks: superior border of teh lateral basilar segments
Definition
horizontal line 1" above inferior angle of the scapula
Term
anatomical landmarks: medial border of the lateral basilar segment
Definition
plumb line bisecting inferior angle of the scapula
Term
anatomical landmarks: lateral border of lateral basilar segment
Definition
mid-axillary line
Term
anatomical landmarks: inferior border of lateral basilar segment
Definition
10th intercostal space posteriorly
Term
anatomical landmarks: superior border of superior basilar segments
Definition
inferomedial aspect of spine of scapula
Term
anatomical landmarks: inferior border of superior basilar segment
Definition
inferior angle of the scapula
Term
anatomical landmarks: superior border of teh posterior basilar segment
Definition
inferior angle of the scapula
Term
anatomical landmarks: lateral border of teh posterior basilar segment
Definition
plumb line bisecting inferior angle of scapula
Term
anatomical landmarks: inferior border of posterior basilar segment
Definition
10th intercostal space
Term
diastolic pulmonary pressure
Definition
5-15 mmHg
Term
what helps drain excess interstiital fluid from the pulmonary circulation
Definition
lymphatic circulation
Term
where is the carina located
Definition
bifurcation of the trachea
Term
where is the carina located
Definition
bifurcation of the trachea
Term
the nasal cavity, sinuses, pharynx, larynx, and trachea all make up what for the respiratory tract
Definition
conducting zone
Term
what is the conducting zone
Definition
filter, warm, moisten, and conduct the air into the lungs
Term
purpose of the larynx
Definition
voice box
Term
purpose of the trachea
Definition
connects the pharynx and larynx to the lungs
Term
3 branchings of the lower respiratory tract
Definition
conducting
transitional
respiratory
Term
gas exchange and the conducting zone
Definition
none
Term
gas exchange and the transitional zone
Definition
some
Term
gas exchange and the respiratory zone
Definition
primary gas exchange
Term
terminal respiratory unites end in what
Definition
alveolar sacs or pouches
Term
alveoli count in normal adult lungs
Definition
300 million
Term
alveolar epithelium contains type I and type II cells, which cell accounts for 93% surface and 8% of the # of cells and are thin and broad
Definition
type I
Term
alveolar epithelium contains type I and type II cells, which produces surfactant
Definition
type II
Term
structures to note within the alveoli (3)
Definition
wandering macrophages
Kahn's pores
Lambert canals
Term
purpose of Lambert Canals
Definition
collateral aveolar ventilation
Term
2 major hygiene mechanisms in the lungs
Definition
mechanical
metabolic
Term
mechanical pulmonary hygiene involves what (2)
Definition
coughing
mucocilliary esclator
Term
metabolic pulmonary hygiene involves what
Definition
lysis by wandering macrophages in the alveoli
Term
How does smoking impair lungs? depressed
Definition
cough reflex
Term
How does smoking impair lungs? impaired (2)
Definition
resistance to infection
mucociliary action
Term
How does smoking impair lungs? disease
Definition
small and medium airway
Term
How does smoking impair lungs? increased
Definition
mucous production
Term
Mechanics of ventilation: diaphragm and accessory mm contract resulting in what
Definition
thoracic cavity pressure decreases below atmospheric
Term
Mechanics of ventilation: thoracic cavity pressure decreases belows atmospheric resulting in what
Definition
air rushing into lungs
Term
Mechanics of ventilation: diaphragm and accessory muscles relax resulting in what
Definition
thoracic pressure returns to normal
Term
Mechanics of ventilation: thoracic pressure returns to normal resulting in what
Definition
air leaving the lungs
Term
paradoxical breathing may be present in what pt population
Definition
paraplegic pt
Term
what happens during parodixcal breathing for inspiration
Definition
chest wall moves inward and the abdomen moves outward
Term
what happens during paradoxical breathing for expiration
Definition
chest wall moves outward and the abdomen moves inward
Term
muscles to note for paradoxical breathing
Definition
intercostals and abdominals are paralyzed/weak so they cannot resist inward pull
Term
what is the respiratory neural center
Definition
medulla
Term
if the medulla was the only thing controlling respiration, what would happen
Definition
rate would be slow and irregular
Low TV
Term
What helps the medulla mediate respiration
Definition
2 areas in the pons
Term
How does the pons helps the medulla in respiration
Definition
mediates rate of breathing so that it is even and rythmical
Term
primary drive to breathe
Definition
removal of CO2 from the body
Term
cbemoreceptors for chemical mediation of respiration
Definition
carotid and aortic bodies
Term
what is the first step of chemical mediation of respiration
Definition
blood brain barrier
Term
what is the chemical mediation of respiration through the blood brain barrier
Definition
H+ indirectly signals CO2 levels
Term
what are the chemoreceptors for chemical mediation of respiration sensitive to
Definition
hypoxemia
Term
stimulates of the chemoreceptors for respiration results in what
Definition
increased respiration
Term
what is the neural input for activity in regards to activity
Definition
spinal cord sending info to the medulla
Term
what info does the SC recieve during activity to increase RR
Definition
skeletal mm receptors: stress, tension, metabolic changes
Term
Juxtacapillary or J receptors are stimulated by what
Definition
hyperinflation of the lungs
Term
J receptors are stimulated by hyperinflation of the lungs and respond by causing what
Definition
shortened inspiration or periods of apnea
Term
J receptors play a role in protecting the lungs during times of threat such as what (3)
Definition
chemicals
thermal agents
environmental stressors
Term
action of the J receptors to protect the lungs during times of threat from chemicals, thermal agents, or other environmental stressors
Definition
reduce TV
constrict the bronchial airways to cause increased mucous production and coughing
Term
what is ventilation/perfusion influenced by
Definition
gravity
positioning
Term
as air descends the lung, what increases faster ventilation or perfusion
Definition
perfusion (about 3x faster)
Term
V/Q in sidelying: regional difference in perfusion are influenced greatest by what
Definition
gravity
Term
elasticity is the ability of tissue to do what
Definition
contract/restrict
Term
compliance is a measure of what
Definition
distensibility of the tissue, ability to expand
Term
what is the inverse of elasticity
Definition
compliance
Term
when something restricts motions (muscular, bony, or tissue) is it a problem with elasticity or compliance
Definition
compliance
Term
tendency of molecules to mvoe from high concentration to low concentration
Definition
diffusion
Term
what is responsible for the gas exchange between teh capillary membranes and the alveolar walls
Definition
diffusion
Term
what percentage of O2 is dissolved into the blood plasma
Definition
3%
Term
97% of O2 is carried by what
Definition
hemoglobin
Term
oxygen being carried hemoglobin makes up what metric that is measured
Definition
O2 sat
Term
percentage of oxygen in atmospheric air
Definition
21%
Term
steps in the oxygen transport system (5)
Definition
air quality and inspired O2
airway
lungs and chest wall
diffusion
perfusion
Term
steps in the O2 transport system: airway refers to what
Definition
throat, bronchi, alveoli and any potential blockages in these
Term
steps in the O2 transport system: lungs and chest walls refers to what (3)
Definition
how compliant?
how elastic?
posture (kyphosis, scoliosis)
Term
steps in the O2 transport system: diffusion refers to what
Definition
needing the correct concentration gradient for diffusion to occur
Term
steps in the O2 transport system: perfusion refers to what
Definition
needing the blood supply to move O2/CO2
Term
steps in the O2 transport system: after perfusion (4)
Definition
myocardial function
peripheral circulation
tissue extraction and utilizaiotn of O2
return of partially de-saturated blood and CO2 to the lungs
Term
3 variables to the Oxygen transport system
Definition
O2 delivery (DO2)
O2 consumption (VO2)
Oxygen extraction ratio (OER)
Term
oxygen dissociation curve: dissocitiation referring to what
Definition
release of O2 from hemoglobin
Term
What happens to O2 saturation in partial pulmonary pressures <50 mmHg
Definition
rapidly drops
Term
How log must partial pulmonary pressure be from O2 saturation to rapidly drop
Definition
<50 mmHg
Term
Oxygen dissociation curve: rates of dissociation are increased with what (3)
Definition
increased temperature (core body temp)
high concentrations of CO2 (CO2 attaches to hemoglobin more easily than O2)
low pH (acidosis)
Term
what is hypoxemia (3)
Definition
state of low PaO2
40-60 mmHg
low O2 in the bloodsteam
Term
hypoxemia can lead to what
Definition
hypoxia
Term
what is normal PaO2
Definition
75-100 mmHg
Term
what is hypoxia
Definition
inadequate O2 at the cells
Term
what is hypoxia influenced by (4)
Definition
level of O2
capillary circulation adequacy
hemoglobin levels
carrying capacity
Term
pulmonary functions changes with aging: elastic recoil
Definition
decreased
Term
pulmonary functions changes with aging: chest wall stiffness
Definition
increased
Term
pulmonary functions changes with aging: alveolar capillary sruface area
Definition
decreased
Term
pulmonary functions changes with aging: forced expiratory flow
Definition
decreased
Term
pulmonary functions changes with aging: total residual volume
Definition
increased
Term
pulmonary functions changes with aging: forced vital capacity
Definition
decreased
Term
pulmonary functions changes with aging: maximum inspiratory and expiratory pressure
Definition
decreased
Term
pulmonary functions changes with aging: ventilation perfusion matching
Definition
decreased
Term
pulmonary functions changes with aging: partial arterial pressure oxygen
Definition
decreased
Term
pulmonary functions changes with aging: o2 sat
Definition
unchanged
Term
pulmonary functions changes with aging: pulmonary vascular resistance
Definition
increased
Term
pulmonary functions changes with aging & exercise response: expiratory flow limitation
Definition
increased
Term
pulmonary functions changes with aging & exercise response: minute ventilation
Definition
increased
Term
pulmonary functions changes with aging & exercise response: work of breathing
Definition
increased
Term
pulmonary functions changes with aging & exercise response: arterial hypoxemia
Definition
unchanged/increased
Term
pulmonary functions changes with aging & exercise response: pulmonary artery pressure
Definition
increased
Term
pulmonary functions changes with aging & exercise response: pulmonary wedge pressure
Definition
increased
Term
pulmonary functions changes with aging: peripheral chemoreceptor sensitivity
Definition
decreased
Term
pulmonary functions changes with aging: thoracic cage and lung tissue compliance
Definition
decreased
Term
pulmonary functions changes with aging: rib and jt changes
Definition
arthritic changes
Term
pulmonary functions changes with aging: respiratory muscle O2 demand
Definition
increases
Term
pulmonary functions changes with aging: all changes lead to what
Definition
increased V/Q mismatch
Term
S/S with aging: increased (2)
Definition
SOB
DOE (Dyspnea on exertion)
Term
S/S with aging: decreased
Definition
overall endurance
Term
S/S with aging: may (2)
Definition
have symptoms of pain or discomfort at ribs or rib jts from arthritis
may show postural changes
Term
Tx of respiratory pathology d/t aging: (5)
Definition
deep breathing, timing, and control ex, other compensatory breathing strategies
maintain thoracic mobility as able
maintain functional endurance
energy conservation techniques
supplemental O2 if needed
Term
anatomical landmarks: sternal notch
Definition
bifurcation of the main bronchi and location of carina
Term
anatomical landmarks: medial third of the clavicle
Definition
apex of the lung is 2-3 cm above this point
Term
anatomical landmarks: 6th rib mid clavicular line
Definition
anterior/inferior border of the lungs
Term
anatomical landmarks: 8th rib mid axillary line
Definition
lateral/ifnerior border of the lungs
Term
anatomical landmarks: T10
Definition
posterior border of the lungs
Term
anatomical landmarks: T4
Definition
posterior apex of lower lobes
Term
anatomical landmarks: medial border of the scapulae when the arms are fully ABducted
Definition
line of the oblique fissures
Term
anatomical landmarks: 4th rib on the right side
Definition
line of transverse fissure
Term
anatomical landmarks: right anterior chest: just superior to clavicle
Definition
apical segment
Term
anatomical landmarks: right anterior chest: 2nd-3rd rib mid clavicular line
Definition
anterior segment of upper lobe
Term
anatomical landmarks: right anterior chest: 6th rib just anterior to mid axillary line
Definition
lateral segment of middle lobe
Term
anatomical landmarks: right anterior chest: 4th rib just lateral to sternum
Definition
medial segment of middle lobe
Term
anatomical landmarks: right anterior chest: 7th rib mid-clavicular line
Definition
anteiror basilar segment
Term
anatomical landmarks: left anterior chest: 4th rib just anterior to mid axillary line
Definition
superior lingula of upper lobe
Term
anatomical landmarks: left anterior chest: 6th rib just lateral to sternum
Definition
inferior lingula of upper lobe
Term
anatomical landmarks: right posterior thoracic cage: along paraspinal mm in between spine of scapula an dinferomedial angle
Definition
posterior segment of upper lobe
Term
anatomical landmarks: right posterior thoracic cage: between inferomedial angle and inferior angle of scapula
Definition
superior basilar segment
Term
anatomical landmarks: right posterior thoracic cage: between inferior angle of scapula and 10th intercostal space
Definition
posterior basilar segment
Term
anatomical landmarks: right posterior thoracic cage: between inferior angle and mid-axillary line at the level of 10th intercostal space
Definition
lateral basilar segment
Term
peak expiratory volume normal healthy adult
Definition
3500-4500 mL
Term
peak flow rate for normal healthy adult
Definition
300 L/min
Term
FVC for normal healthy adult
Definition
4.0L
Term
FEV1 for normal healthy adult
Definition
3.0L
Term
IRV
Definition
inspiratory reserve volume
Term
what is inspiratory reserve volume
Definition
additional inspiration volume after tidal volume inspiration
Term
IRV as a % of TLC
Definition
50%
Term
ERV
Definition
expiratory reserve volume
Term
what is expiratory reserve volume
Definition
additional expiration volume after tidal volume expiration
Term
ERV is what % of TLC
Definition
15%
Term
RV
Definition
residual volume
Term
what is residual volume
Definition
air that cannot be expelled from the lungs
Term
residual volume is what % of TLC
Definition
25%
Term
IC
Definition
inspiratory capacity
Term
what is inspiratory capacity
Definition
amount of air that can be inspired after tidal volume expiration
Term
IC is what % of TLC
Definition
60%
Term
VC
Definition
vital capacity
Term
what is vital capacity
Definition
maximum amount of air that can be moved in and out of the lungs
Term
volume of vital capacity
Definition
3500-4500 mL
Term
total lung capacity volume
Definition
5-6 L
Term
what is total lung capacity
Definition
sum of VC+residual volume
Term
TLC
Definition
total lung capacity
Term
TV
Definition
tidal volume
Term
what is tidal volume
Definition
air moved during breathing at rest
Term
normal values for TV
Definition
350-400 mL
Term
what is minute ventilation
Definition
TV x RR
Term
FEV1
Definition
functinoal expiratory volume for 1 second
Term
what is FEV1
Definition
amount of air as a % of VC that can be expired in 1 sec
Term
what is the normal percentage of VC that FEV1 should be
Definition
75-80% of VC
Term
Vd
Definition
anatomical dead space
Term
what is Vd (anatomical dead space)
Definition
air that must move through the conducting respiratory zone with each breath
Term
how much anatomical dead space is there (Vd)
Definition
150 mL
or # of mL = weight in lbs
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