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Details

Pulm-Pharm
TB pharmocology
28
Pharmacology
Graduate
10/06/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Adverse Effects of Rifamycin
Definition

Hepatotoxic

P450 Inducer

Hypersensitivity

Term
Adverse effects of Isoniazid
Definition

Hepatotoxicity

Neurotoxic: Inhibits B6 uptake

Lupus-like

Phenytoin Interaction

Term
Adverse Effects of Ethambutol
Definition

Optic Neuritis: Red-green, and acuity loss

GI symptoms

Term
Adverse Effects of Pyrazinamide
Definition

Most Hepatotoxic of TB Drugs

Hyperureacemia

Arthralgia

Term
Adverse Effects of Streptomycin
Definition
Nephrotoxicity, Non-reversible Ototoxicity
Term
Adverse effects of Cycloserine
Definition
Psychosis, Peripheral Neuropathy
Term
Mechanism of Rifamycin
Definition
Block B1 unit of RNA Polymerase
Term
Mechanism of Isoniazid
Definition
Block FASII for mycolic acid synthesis
Term
Mechanism of Ethambutol
Definition
Blocks Arabinosyl Transferase
Term
Mechanism of Pyrazinamide
Definition
Block FASI in mycolic acid synthesis
Term
Mechanism of Streptomycin
Definition
Binds 30S subunit of Ribosome
Term
Mechanism of Cycloserine
Definition
Block D-ala-D-ala Synthetase and Ala Racemase
Term
Is Rifabutin used to treat Rifamycin-resistant TB? Why?
Definition
resistance is conferred to both
Term
What populations are fast/slow acetylators of INH?
Definition

Fast: Japanese, Inuits

Slow: Scandenavians, Jews

Term
What toxicity screening test are run for the normal course of TB Treatment
Definition
Liver Function, Renal Function, Vision, Oto, Neuropathy
Term
Excretion of Rifamycin
Definition

Most Biliary

30% by Renal

Term
Is Rifamycin or Rifabutin a high P450 inducer
Definition
Rifamycin
Term
Why is Rifamycin never used alone
Definition
Common Spontaneous Resistance
Term
Which TB Drugs are prodrugs
Definition

Isoniazid,

Pyrinizamine

Term
Aminogycosides besides Streptomycin used in TB Treatment
Definition
Kanamycin and Amikacin
Term
Flouroquinolones used in Tb
Definition
Moxifloxacin (MACand TB), Gatifloxacin
Term
TB Treatment Regimen
Definition

INH+RIF+PZA+ETH->Sensitive->
INH+RIF+PZA(2 months)-> INH+RIF (4 months, 7 months(HIV))

 

Term
Why is ethambutol contraindicated in children under six
Definition
Optic nerve damage is more prevailent in developing children
Term
What drug is current a second line TB drug but may become a first line because of it effectiveness
Definition
Fluoroquinolones esp Moxifloxacin
Term

What TB drug has...

Optic Neuritis

Neuropathy

Lupus-like

Most Hepatotoxic

Psychosis

Ototoxic

Nephrotoxic

Stephen's Johnson's

Hyperureacemia

Arthralgia

P450 Inducer

Definition

Optic Neuritis: Ethambutol

Neuropathy: Cycloserine, Isoniazid

Lupus-like: Isoniazide

Most Hepatotoxic: Pyrazinamide

Psychosis: Cycloserine

Ototoxic: Streptomycin

Nephrotoxic: Streptomycin

Stephen's Johnson's: Rifamycin

Hyperureacemia: pyraznamide

Arthralgia: pyrazinamide

P450 Inducer: Rifamycin

Term
What is the mechanis of isoniazid neurotoxicity?
Definition
B6 uptake inhibition
Term

Which of the quadruple therapy drugs can killed intracellular Mycobacterium?

Which requires a low pH to activate?

Definition

Isoniazid and Pyrazinamide

Low pH: pyrazinamide

Term
How does resistance to Isoniazid occur?
Definition

FASII mutation

Catalase-Peroxidase Mutation

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