Term
| Signs of Streptococcus pneumoniae Pneumonia |
|
Definition
Rales, Dull Sounds
CXR: Lobar Consolidation
WBC: Elevated |
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|
Term
| Morphology of S. pneumoniae |
|
Definition
| Gram (+) diplococci/laceletpairings |
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Term
|
Definition
| Catalase(-), Optochin Sensitive, Alpha-Hemolytic, Detergent/Bile Lysis |
|
|
Term
| Diagnosis of S. pneumoniae |
|
Definition
Culture
Latex Agglutination of Capsular Antigen
Quelling Reaction |
|
|
Term
|
Definition
| Staph aureus, Streptococcus pneumoniae, Pseudomonas aeruginosa, Legionella pneumoniae |
|
|
Term
| Transmission of S. pneumoniae |
|
Definition
| Endogenous or Respiratory Secretions |
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|
Term
| Suseptibility to S. pneumoniae |
|
Definition
| Trauma, DM, Smoking, Alcohol, Chronic Lung Disease, Malignany, Chronic Antibiotics, Narcotics, Renal Failure |
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|
Term
| Pathology of S. Pneumoniae |
|
Definition
| Inflamation, Edema and Pus Formation |
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|
Term
| Complications of S. Pneumoniae |
|
Definition
| (#1)Otitis Media, (#1)Meningitis, Bacteremia, Sinusitis |
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|
Term
| S.pneumoniae Virulence Factors |
|
Definition
IgA Protease
Pneumolysin
Capsule: Higher density increases Virulence, 80 Serotypes, 23 cause 90% of pneumonias from S. pneumoniae |
|
|
Term
| Immunity to S. pneumoniae |
|
Definition
Innate: C3b, Phagocytosis
Adaptive: IgG(Phagocytosis), IgM(complement) |
|
|
Term
| Treatment of S. pneumoniae |
|
Definition
Ampicillin/ B-lactams-> Fluroquinolones or Vancomycin
50% PBP Alterations |
|
|
Term
| Prevention of S. pneumoniae |
|
Definition
Vaccine:
1)Susceptible (elder/Immunosupressed): 23 polysacciride Immunization
2)Children 7 Polysacchirides bound to protein |
|
|
Term
| Strep pneumoniae Buzz Words |
|
Definition
| Lobar Consolidation, Acute Onset, Shaking Chill, Pink/Red Sputum |
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|
Term
| Morphology of Klebsiella pneumoniae |
|
Definition
|
|
Term
| Epidemiology of K. pneumoniae |
|
Definition
|
|
Term
| Virulence Factors of K. pneumoniae |
|
Definition
|
|
Term
| Lab Diagnosis of K.pneumoniae |
|
Definition
MBE, or Mackonkey agar,
Biochem tests |
|
|
Term
|
Definition
| Klebsiella pneumoniae, E. cloi, Enterobacter |
|
|
Term
| Presentation of K. pneumoniae Pneumonia |
|
Definition
| Necrotizing Pneumonia with Currant Jelly Bloody Sputum |
|
|
Term
| Morphology of Pseudomonas aeroginosa |
|
Definition
| Aerobic, Motile, Gram(-) Rods |
|
|
Term
| Virulence of P.aeruginosa |
|
Definition
Enterotoxin A: Adp-ribosylation of EF-2
Endo,Exo,Enterotoxins
Hemolysin, Leucocidin, Preoteolytic Enzymes
Capsule, Pilli |
|
|
Term
| Epidemiology of P.aeruginosa |
|
Definition
| Intestine, Skin, 15% of Nosocomial Pneumonias |
|
|
Term
| Susceptibility to P.aeruginosa |
|
Definition
| Extensive Burns, CF with Ventilator, Predisposition |
|
|
Term
| Complications of P.aeruginosa |
|
Definition
| Osteomyelitis, Bacteremia |
|
|
Term
| Lab Characteristics of P aeruginosa |
|
Definition
| Oxidase(+), Pneumocyanin, Pneumoverdin |
|
|
Term
| Pseudomonas aeroginosa Treatment |
|
Definition
| Susceptibility Test, followed by combo therapy |
|
|
Term
| Morphology of Mycoplasm pneumoniae |
|
Definition
| Small, Pleomorphic, coccobacillus, w/o cell wall |
|
|
Term
| Mycoplasm pneumoniae Culture |
|
Definition
| Complex Media: Sterols, Lipoprotein, 5% CO2 |
|
|
Term
| Pneumonias that require a source for infection |
|
Definition
| Legionella pneumonphila, Coxiella burnetii, Mycobacterium avium |
|
|
Term
| Epidemiology of Mycoplasm pneumoniae |
|
Definition
| 15% of Pneumonias, 50%of PAPs |
|
|
Term
| Pathogenesis of M. pneumoniae |
|
Definition
| Cytoadhesins PI with ROS prodution |
|
|
Term
| Presentation of M.pneumoniae |
|
Definition
Nonproductive Cough,Patchy Infiltrate (CXR)
1-2wk incubation-> PAP-> 1-4wk Resolution
Infectious after resolution |
|
|
Term
| Lab Diagnosis of M.pneumoniae |
|
Definition
Antigen Serology
Cold Agglutination Titer
Culture: Fried Egg on Sterol,lpa,CO2 |
|
|
Term
| Treatment of M.pneumoniae |
|
Definition
| Doxacycline or Erythromycin |
|
|
Term
| Morphology of Legionella pneumophila |
|
Definition
|
|
Term
| Lab Testing of L. pneumonphila |
|
Definition
Oxidase(+), Catalase(+)
Culture on Buffered Charcoal Yeast Agar |
|
|
Term
| Epidemiology of Legionella pneumonphila |
|
Definition
Water towers, Shower focets, Air conditioners
Nosocomial, Biofilms, Amoebae
Elderly |
|
|
Term
| Presentation of L. pneumonphila |
|
Definition
| Bronchitis-> Confluent Pneumonia/GI Symptoms-> Abcess-> Shock, DIC |
|
|
Term
| Pathogenesis of Legionella |
|
Definition
| Prevent Phagosome-Lysosome Fusion, Resist Oxidative Damage |
|
|
Term
| Legionella with mild Walking Pneumonia |
|
Definition
|
|
Term
| Transmission of Legionella |
|
Definition
|
|
Term
| Lab Diagnosis of Legionella |
|
Definition
Culture BCYE
EIA Urine: Picks up 80% Community strain, 20% of Nosocomial Strains
Nucleic Acid: Future |
|
|
Term
|
Definition
| Macrolides (Azithromycin), Fluroquinolones (Levofloxacin) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Chlorine, Heat, Copper/silver agents |
|
|
Term
| Presentation of Chlamydia Psittaci |
|
Definition
| Bird Contact->PAP(w/ photophobia, and severe Headache) -> Consolidation -> 20% mortality |
|
|
Term
|
Definition
Psittacosis: Parrot
Ornithosis: Non-Parrot |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Presentation of Chlamydia pneumoniae |
|
Definition
|
|
Term
| Epidemiology of C.pneumoniae |
|
Definition
| 20% of Young Community Acquired Pneumonia |
|
|
Term
| Diagnosis of C.pneumoniae |
|
Definition
|
|
Term
| Epidemiology of Coxiella burnetii |
|
Definition
Sheep, Cows, Goats
In milk, Placenta, Hydes, Feces, Urine |
|
|
Term
|
Definition
| PAPS-> Hepatitis/ Endocarditis |
|
|
Term
| Disease of Coxiella burnetii |
|
Definition
|
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