Shared Flashcard Set

Details

PTherapeutics I T2 SE Drugs
Status Epilepticus Drugs
36
Pharmacology
Professional
04/03/2011

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Cards

Term
Which drug has weight based dosing, is very lipophilic and has a large VD?
Definition
Diazepam
Term
What drug should be given with another anti-epileptic because a rapid decrease in brain concentration can cause rapid seizure recurrence?
Definition
Diazepam
Term
How frequently can Diazepam be repeated if no response?
Definition
5 minutes
Term
How frequently can Diazepam be repeated if no response?
Definition
5 minutes
Term
What drug has minimal reidstribution to fat which results in longer DoA in the CNS?
Definition
Lorazepam
Term
What is the max infusion rate of Lorazepam?
Definition
2mg/min
Term
what is the max dose of Lorazepam to be given?
Definition
8mg in 12 h
Term
What is the BZD of choice in SE?
Definition
Lorazepam
Term
Which drug may require a higher dose due to tolerance?
Definition
Lorazepam
Term
Lorazepam offers seizure protection for____
Definition
up to 24 hours
Term
Which drug must be given by continuous infusion? why?
Definition
Midazolam; short half life
Term
Midazolam may be given by ______ if IV access not available.
Definition
IM or buccal
Term
which drug is first line for refractory SE?
Definition
Midazolam
Term
Hypotension and respiratory depression are effects of____
Definition
Midazolam
Term
Patients respond to midazolam in______
Definition
an hour
Term
with which drug to PTs return to consciousness more rapidly?
Definition
Midazolam
Term
Which drug is used if no response to BZDs?
Definition
Phenytoin
Term
Hypotension or cardiac arrhythmias may arise due to _______as the drug vehicle fo _______
Definition
propylene glycol is the drug vehicle for phenytoin
Term
Which drug has an alkaline pH, can cause burning during infusion, and may cause phlebitis and necrosis?
Definition
Phenytoin
Term
Phenytoin is not first line because_____
Definition
infusion rate is limited and cannot be delivered fast enough
Term
max infusion rates for phenytoin?
Definition
50 mg/min in adults
.5-1 mg/kg/min in children
Term
____is a phenytoin prodrug
Definition
fosphenytoin
Term
Fosphenytoin is easier to administer because_____ and therefore does not cause_____.
Definition
it is water soluble and has no propylene glycol; BP or EKG changes
Term
Drug's AE's are: Nystagmus, ataxia, BP changes (less than phenytoin), nonallergic parathesias and facial & groin itching
Definition
Fosphenytoin
Term
Which drug has SEs of apnea and hypoapnea?
Definition
Phenobarb
Term
This drug also has propylene glycol, but may be delivered faster than phenytoin
Definition
Phenobarb
Term
how frequently may phenobarb be given?
Definition
20-30 minutes after 1st dose; a 3rd may be given (10mg/kg)
Term
What is given if a PT does not respond to Midazolam?
Definition
Pentobarb
Term
How is Pentobarb given?
Definition
LD followed by continuous infusion
Term
Which drug may cause hypotension?
Definition
pentobarb
Term
This drug should be given with other antiepileptics at therapeutic doses to decrease risk of seizure recurrence upon withdrawal
Definition
Pentobarb
Term
Which drug has comparative efficacy to midazolam and has SEs of metabolic acidosis and arrhythmias?
Definition
Propofol
Term
Which drug has a very short t 1/2 to promote rapid awakening on withdrawal?
Definition
propofol
Term
Which drug is extremely rapid onset, extremely lipid soluble, and can provide over 1000 calories/day in lipid form?
Definition
Propofol
Term
Which drug must have its acid-base status monitored and maintain hydration to prevent kidney stones?
Definition
Topiramate
Term
Which drug is not recommended because accumulation can cause CNS toxicity?
Definition
Lidocaine
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