Term
Which drug has weight based dosing, is very lipophilic and has a large VD? |
|
Definition
|
|
Term
What drug should be given with another anti-epileptic because a rapid decrease in brain concentration can cause rapid seizure recurrence? |
|
Definition
|
|
Term
How frequently can Diazepam be repeated if no response? |
|
Definition
|
|
Term
How frequently can Diazepam be repeated if no response? |
|
Definition
|
|
Term
What drug has minimal reidstribution to fat which results in longer DoA in the CNS? |
|
Definition
|
|
Term
What is the max infusion rate of Lorazepam? |
|
Definition
|
|
Term
what is the max dose of Lorazepam to be given? |
|
Definition
|
|
Term
What is the BZD of choice in SE? |
|
Definition
|
|
Term
Which drug may require a higher dose due to tolerance? |
|
Definition
|
|
Term
Lorazepam offers seizure protection for____ |
|
Definition
|
|
Term
Which drug must be given by continuous infusion? why? |
|
Definition
Midazolam; short half life |
|
|
Term
Midazolam may be given by ______ if IV access not available. |
|
Definition
|
|
Term
which drug is first line for refractory SE? |
|
Definition
|
|
Term
Hypotension and respiratory depression are effects of____ |
|
Definition
|
|
Term
Patients respond to midazolam in______ |
|
Definition
|
|
Term
with which drug to PTs return to consciousness more rapidly? |
|
Definition
|
|
Term
Which drug is used if no response to BZDs? |
|
Definition
|
|
Term
Hypotension or cardiac arrhythmias may arise due to _______as the drug vehicle fo _______ |
|
Definition
propylene glycol is the drug vehicle for phenytoin |
|
|
Term
Which drug has an alkaline pH, can cause burning during infusion, and may cause phlebitis and necrosis? |
|
Definition
|
|
Term
Phenytoin is not first line because_____ |
|
Definition
infusion rate is limited and cannot be delivered fast enough |
|
|
Term
max infusion rates for phenytoin? |
|
Definition
50 mg/min in adults .5-1 mg/kg/min in children |
|
|
Term
____is a phenytoin prodrug |
|
Definition
|
|
Term
Fosphenytoin is easier to administer because_____ and therefore does not cause_____. |
|
Definition
it is water soluble and has no propylene glycol; BP or EKG changes |
|
|
Term
Drug's AE's are: Nystagmus, ataxia, BP changes (less than phenytoin), nonallergic parathesias and facial & groin itching |
|
Definition
|
|
Term
Which drug has SEs of apnea and hypoapnea? |
|
Definition
|
|
Term
This drug also has propylene glycol, but may be delivered faster than phenytoin |
|
Definition
|
|
Term
how frequently may phenobarb be given? |
|
Definition
20-30 minutes after 1st dose; a 3rd may be given (10mg/kg) |
|
|
Term
What is given if a PT does not respond to Midazolam? |
|
Definition
|
|
Term
|
Definition
LD followed by continuous infusion |
|
|
Term
Which drug may cause hypotension? |
|
Definition
|
|
Term
This drug should be given with other antiepileptics at therapeutic doses to decrease risk of seizure recurrence upon withdrawal |
|
Definition
|
|
Term
Which drug has comparative efficacy to midazolam and has SEs of metabolic acidosis and arrhythmias? |
|
Definition
|
|
Term
Which drug has a very short t 1/2 to promote rapid awakening on withdrawal? |
|
Definition
|
|
Term
Which drug is extremely rapid onset, extremely lipid soluble, and can provide over 1000 calories/day in lipid form? |
|
Definition
|
|
Term
Which drug must have its acid-base status monitored and maintain hydration to prevent kidney stones? |
|
Definition
|
|
Term
Which drug is not recommended because accumulation can cause CNS toxicity? |
|
Definition
|
|