Term
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Definition
Thiazides beta-blockers (Toprol) birth control ethanol each can cause a 50% increase in TG
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Term
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Definition
statin atorvastatin 10,20,40,80 compeling indication for DM (statins in general) First line drug if choice (statins in general) |
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Term
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Definition
statin Simvastatin 5-80mg 20-40mg qHS
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Term
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Definition
statin Pravastatin 40-80mg qd more hyprophilic, less myalgia |
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Term
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Definition
statin Lovastatin 10-80 qd 20mg
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Term
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Definition
statin fluvastatin 40-80mg
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Term
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Definition
statin Rosuvastatin 5-10mg most potent more hydrophilic, less myalgia |
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Term
| statin ADE's and contraindications |
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Definition
ADE: myalgia, myocitis Contraindications: liver disease |
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Term
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Definition
do not add on fibrates or fish oils fibrates are: Lopid- gemfibrozil Tricor- fenofibrate
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Term
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Definition
bile acid resin cholestyramine use: decrease LDL up to 50% when with statin
ADE: increases TG up to 30% contraindicated for TG > 400
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Term
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Definition
bile acid resin colestipol
use: decrease LDL up to 50% when with statin
ADE: increases TG up to 30% contraindicated for TG > 400 least likely to cause myalgias
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Term
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Definition
bile acid resin colesevelam use: decrease LDL up to 50% when with statin
ADE: increases TG up to 30% contraindicated for TG > 400 |
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Term
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Definition
cholesterol absorption inhibitor esetimibe 10mg qd 18% reduction in LDL alone and additional 25% when with a statin
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Term
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Definition
nicotinic acid 500mg-1000mg decrease TG 50% (most)
raise HDL 35% (most) ADE: flushing Contraindications: liver disease, gout *careful in diabetes
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Term
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Definition
Fibrate genfibrozil 600mg increase HDL 20% decrease TG 50% contraindications: kidney/liver patients
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Term
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Definition
Fibrate fenofibrate
600mg increase HDL 20% decrease TG 50% contraindications: kidney/liver patients |
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Term
| taking fibrates while having high TG levels causes |
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Definition
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Term
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Definition
Increase HDL 9%- good Increase LDL 45%- bad |
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