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Psychopharmacology Exam 2
Neurons, neurotransmitters, and pathologies
53
Pharmacology
Undergraduate 4
02/13/2023

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Term
Neurons
Definition
What cells transmit information in the form of electrical signaling?
Term
Interneurons
Definition
What type of cells form interacting neural circuits and are involved in conscious sensations, recognition, memory, decision-making, and cognition?
Term
Sensory Neurons
Definition
What types of cells convert physical stimuli into electrical impulses?
Term
Motor Neurons
Definition
What type of cells direct biobehavioral responses in situations of physical risk?
Term
Glial Cells
Definition
What type of cells provide metabolic support, protection, and insulation for neurons?
Term
Astrocytes, Microglia, Schwann cells, and Oligodendroglia
Definition
What are the (4) types of glial cells?
Term
Astrocytes and microglia
Definition
What two types of glial cells perform phagocytosis?
Term
Astrocytes
Definition
What type of glial cells provide structural support, maintain the ionic and chemical environment, perform phagocytosis and store nutrients to provide energy for neurons?
Term
Microglia
Definition
What type of glial cells perform phagocytosis and the immune system of the brain?
Term
Schwann Cells
Definition
What type of glial cells form a myelin sheath on the axons of neurons in the peripheral nervous system, release growth factors following neuron damage, and provide channels to guide neurons to their targets?
Term
Oligodendoglia
Definition
What type of glial cells form the myelin sheath of neurons in the central nervous system and inhibit the regrowth of axons following neuron damage?
Term
Myelin Sheath
Definition
What is the name of the fatty insulation surrounding axons and created by glial cells?
Term
Nodes of Ranvier
Definition
What are breaks in the myelin sheath where action potentials are regenerated?
Term
Increase speed of conduction
Definition
What is the purpose of the myelin sheath?
Term
faster conduction
Definition
With an increase in the thickness of the myelin sheath comes _____.
Term
Convergence
Definition
What is the phenomenon called when a single neuron receives and integrates information from many neurons?
Term
Divergence
Definition
What is the phenomenon called when a single neuron transmits information to a few (but up to thousand of) other neurons?
Term
increase surface area
Definition
What is the purpose of dendritic spines?
Term
rapid change in shape/constantly modified
Definition
What characteristic of dendrites and their spines allow humans to continuously learn new associations?
Term
prolonged synaptic activity
Definition
What can lead to changes in the number, size, and shape of dendritic spines?
Term
fewer or smaller
Definition
What word can be used to describe the dendritic spines of individuals with some mental impairments compared to those without?
Term
Transcription Factors
Definition
What are modified in response to prolonged stress or chronic drug use that change whether or not a protein is made?
Term
epigenetics
Definition
What word can be used to describe changes in genetic expression without affecting chromosomal DNA?
Term
epigenetic
Definition
Methylation, acetylation, and phosphorylation are examples of _____ modification.
Term
cell differentiation
Definition
What purpose do epigenetic modifications serve in a developing fetus?
Term
environmental factors
Definition
Epigenetics can be affected by _____, which is why monozygotic twins who aren't raised together can have different disorders, be more susceptible to addiction than their sibling, or become clinically depressed following abuse or neglect.
Term
Axoplasmic Transport
Definition
What process uses a network of microtubules and neurofilaments (cytoskeleton) and motor proteins to transport proteins to other parts of the cell?
Term
K+, Na+, Cl-, and Ca2+
Definition
What ions are needed for neuronal function and must use ion channel to move?
Term
ligand-gated and voltage-gated
Definition
What are the two types of ion channels that are usually closed but open in response to a stimuli?
Term
phosphate group
Definition
What do second messengers use to regulate the state of ion channels?
Term
Resting Membrane Potential
Definition
What is the difference in electrical charge between the inside and the outside of a cell?
Term
inside is 70 mV more negative
Definition
What is the difference (voltage) between the inside and the outside of a neuron?
Term
electrostatic pressure
Definition
K+ ions flow freely into the cell due to _____.
Term
concentration gradient, electrostatic pressure
Definition
K+ ions reach their equilibrium potential when _____ is balanced with _____.
Term
3 Na+ out, 2 K+ in; against
Definition
What is the number and direction of ion movement facilitated by the sodium/potassium pump? In what directions are the ions moving in relation to their concentration gradient?
Term
depolarization
Definition
Na+ channels opening and allowing Na+ to enter the cell results in _____.
Term
Cl-

K+
Definition
The influx of what ion results in inhibition of an action potential via hyperpolarization?

What ion causes hyperpolarization by flowing out?
Term
excitatory postsynaptic potentials (EPSPs)
Definition
_____ cause small, localized depolarizations that move the membrane potential closer to the threshold for firing
Term
inhibitory postsynaptic potentials (IPSPs)
Definition
_____ cause small, localized hyperpolarizations that move the membrane potential further from the threshold for firing
Term
axon hillock
Definition
Where does the integration of EPSPs and IPSPs occur?
Term
Na+
Definition
What rushes into the cell quickly during the rising phase?
Term
+40mV
Definition
What is the membrane potential after an action potential takes place?
Term
K+
Definition
After an action potential, voltage-gated channels open to move ______ back out of the cell to restore the resting membrane potential.
Term
Na+ channels' inability to reopen
Definition
What causes the absolute refractory period?
Term
relative refractory period
Definition
What is the name for the period of time when the membrane is hyperpolarized and needs more of a stimulus to cause an action potential?
Term
1 millisecond
Definition
How long does an action potential last?
Term
intensity of stimulus
Definition
What is coded by rate of firing?
Term
none/unrelated
Definition
What's the relationship between the size of the action potential and the amount of stimulation?
Term
Nodes of Ranvier
Definition
Saltatory conduction jumps along the axon because action potentials are generated at _____.
Term
Na+/K+ pumps
Definition
What piece of cellular machinery located at Nodes of Ranvier make saltatory conduction more efficient?
Term
local anesthesia, anti-epileptics
Definition
What are the types of drugs that are effective due to blocking voltage-gated Na+ channels?
Term
saxitoxin
Definition
What substance in shellfish exposed to red tides causes death by suffocation due to blockage of voltage-gated Na+ channels?
Term
tetrodotoxin
Definition
What substance in Japanese puffer fish causes death in less than 8 hours by blocking voltage-gated Na+ channels?
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