- antidepressant, single-mechanism

- selective serotonin reuptake inhibitor (SSRI)

- relatively few SEs, safety in OD

- Zoloft

Sertraline

- antidepressant, single-mechanism

- selective serotonin reuptake inhibitor (SSRI)

- relatively few SEs, safety in OD

- Prozac

Fluoxetine

- antidepressant, single-mechanism

- selective serotonin reuptake inhibitor (SSRI)

- relatively few SEs, safety in OD

- Paxil

Paroxetine

- antidepressant, single-mechanism

- selective serotonin reuptake inhibitor (SSRI)

- relatively few SEs, safety in OD

Fluvoxamine

- antidepressant, single-mechanism

- selective serotonin reuptake inhibitor (SSRI)

- relatively few SEs, safety in OD

- S-enantiomer = Escitalopram

Citalopram

- Dual mechanism, "clean" drug

- Transmission in two amine systems

- Serotonin plus NE

Venlafaxine

- Dual mechanism, "clean" drug

- Transmission in two amine systems

- Serotonin plus NE

Mirtazapine

- Dual mechanism, "clean" drug

- Transmission in two amine systems

- Serotonin plus NE

- Cymbalta

Duloxetine

- Dual mechanism, "clean" drug

- Transmission in two amine systems

- Dopamine plus NE

- Avoid in pts with bulimia or seizures

Bupropion

- Dual mechanism, "dirty" drug

- Limited current use due to SEs and lethality w/ OD

- Tricyclic antidepressants

- (block reuptake of NE and Serotonin)

Amitriptyline

- Dual mechanism, "dirty" drug

- Limited current use due to SEs and lethality w/ OD

- Tricyclic antidepressants

- (block reuptake of NE and Serotonin)

Nortriptyline

- Dual mechanism, "dirty" drug

- Limited current use due to SEs and lethality w/ OD

- Tricyclic antidepressants

- (block reuptake of NE and Serotonin)

Imipramine

- Dual mechanism, "dirty" drug

- Limited current use due to SEs and lethality w/ OD

- Tricyclic antidepressants

- (block reuptake of NE and Serotonin)

Desipramine

- Dual mechanism, "dirty" drug

- Limited current use due to SEs and lethality w/ OD

- Tricyclic antidepressants

- (block reuptake of NE and Serotonin)

Clomipramine

- Monamine Oxidase Inhibitors (MAOIs)

- disable MAO t/o body, increased NE and serotonin

- Irreversible MAOIs

- (fatal in OD, high risk of serotonin syndrome)

Phenelzine

- Monamine Oxidase Inhibitors (MAOIs)

- disable MAO t/o body, increased NE and serotonin

Selgiline transdermal patch

- Mood stabilizer

- treatment for mental disorders

- 1st developed as treatment for epilepsy (anticonvulsant)

Lithium

- Mood stabilizer

- treatment for mental disorders

- 1st developed as treatment for epilepsy (anticonvulsant)

Valproate/Valproic Acid

- Mood stabilizer

- treatment for mental disorders

- 1st developed as treatment for epilepsy (anticonvulsant)

Lamotrigine