Term
| Which antidepressants have adverse cardiac effects? |
|
Definition
|
|
Term
| What is the treatment of choice for atypical depression? |
|
Definition
|
|
Term
| What are the contraindications to bupropion? |
|
Definition
| seizure, eating disorders |
|
|
Term
| How should an MAOI-induced hypertensive crisis be treated? |
|
Definition
1) a-blocker IV (phentalomine)
2) chlorpromazine IM or PO
3) nifedipine PO |
|
|
Term
| What is the pharm mechanism of action of mirtazapine? |
|
Definition
|
|
Term
| What SSRI has the longest halflife? The shortest? |
|
Definition
longest - fluoxetine (7-15 days)
shortest - fluvoxamine (15 hrs) |
|
|
Term
| What is the only SSRI with clinically active metabolites? |
|
Definition
|
|
Term
| What is most likely to be the cause of fatality in TCA overdose? |
|
Definition
| cardiac arrhythmia and death |
|
|
Term
| Which TCA has blood levels that are related to its clinical effect and needs to be monitored? |
|
Definition
|
|
Term
| Which benzos are safe to use in pts with compromised hepatic function? |
|
Definition
temazepam
oxazepam
lorazepam |
|
|
Term
| Which benzos are available in parenteral form? |
|
Definition
chlordiazepoxide
diazepam
lorazepam
midazolam |
|
|
Term
| What is the drug of first choice in tx of catatonia? |
|
Definition
| benzos - usually IM Ativan |
|
|
Term
|
Definition
Discontinue antipsychotics
IV hydration
Cooling
Dantrolene
Bromocriptine |
|
|
Term
| What is the most common SE of clozapine? Most severe? |
|
Definition
most common - sedation
most severe - seizures, agranulocytosis, NMS |
|
|
Term
| What is the mechanism by which NMS occurs? |
|
Definition
| blockade of dopamine receptors |
|
|
Term
| What are the SE of lithium |
|
Definition
tremor, nephrogenic DI, wt gain, hypothyroidism, rash
NO adverse affects on respiratory system |
|
|
Term
| What is the treatment of choice for rapidly cycling mood disorder? |
|
Definition
| anticonvulsant agents like valproic acid |
|
|
Term
| What lab test is needed in carbamazepine-treated pts at 2-wk intervals during the first 2 mo of treatment? |
|
Definition
CBC
also, LFT to detect drug-induced hepatitis |
|
|
Term
| What drugs cause drug-induced delayed ejaculation and retrograde ejaculation? |
|
Definition
|
|
Term
| How are EPS treated? (akathisia and acute dystonia) |
|
Definition
akathisia - propranolol
acute dystonia - benztropine or diphenhydramine |
|
|
Term
| Which typical antipsychotic agent is least likely to cause weight gain? |
|
Definition
|
|
Term
| What psychiatric meds cause priapism? |
|
Definition
trazodone
others may include venlafaxine, levodopa, sildenafil |
|
|
Term
| Retinal pigmentation is an adverse effect of which antipsychotic agent? |
|
Definition
| thioridazine (Mellaril) at high doses |
|
|
Term
| What pharm tx is available for OCD? |
|
Definition
| high dose serotonergics - SSRIs, clomipramine, MAOIs |
|
|
Term
|
Definition
| headache, confusion, delirium, memory impairment (no permanent brain damage) |
|
|
Term
| What psych meds require routine monitoring of their serum levels? |
|
Definition
| lithium, desipramine, nortriptyline, valproic acid, carbamazepine |
|
|
Term
| Withdrawal from what substance may cuase grand mal seizure as well as severe anxiety and insomnia? |
|
Definition
| alcohol, benzos, barbiturates, meprobomate (nonbenzo anxiolytic agent with muscle-relaxant properties) |
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