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Psych/Neuro EXAM 1
Psych/Neuro EXAM 1 Gable Intro
23
Pharmacology
Graduate
08/16/2011

Additional Pharmacology Flashcards

 


 

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Term
public perceptions of mental illness
Definition
due to emotional weakness
caused by bad parenting
victim's fault; can will it away
incurable
consequence of sinful behavior
has a biological basis; involves the brain
Term
DSM-IV Axis I
Definition
clinical (psychiatric) disorders

EX) OCD, schizophrenia, ADHD
Term
DSM-IV Axis II
Definition
personality disorders, mental retardation
Term
DSM-IV Axis III
Definition
general medical conditions
Term
DSM-IV Axis IV
Definition
psychosocial and environmental problems

problems with primary support group (divorce)
educational problems (illiterate)
occupational problems (unemployed)
housing problems (homeless)
Term
DSM-IV Axis V
Definition
Global Assessment of Functioning

ranges from 0-100

normal = 80-90
< 30 = actively psychotic
< 20 = suicidal or homicidal
Term
DSM-IV clinical disorders
Definition
disorders diagnosed in childhood (ADHD)
dementia and delirium
psychotic disorders (schizophrenia)
affective disorders (major depression; bipolar disorder)
anxiety disorder (OCD, panic disorder)
somatoform disorder (hypochondriasis) - not treated with drugs
dissociative disorders - not treated with drugs
substance use disorders (alcohol, cocaine)
eating disorders
sleep disorders
Term
psychiatric patient assessment
Definition
HPI: worries, preoccupations, changes in mood, suspicions, delusions or hallucinatory experiences, recent changes in sleep, appetite, libido, concentration, memory, or behavior, including suicidal or aggressive behaviors

past psychiatric history: chronology of past episodes of mental illness

family and social history

general medical history and physical exam

laboratory evaluation

medication history
Term
The Mental Status Exam
Definition
the cornerstone of the psychiatric interview

AMSIT

Appearance
Mood and Affect
Sensorium
Intelligence
Thought
Term
factors for appearance
Definition
age, race, gender, grooming, dress, hygiene, dentition

BEHAVIOR: attitude, psychomotor activity, eye contact, gait, posture, impulse control, abnormal movements

SPEECH: rhythm, rate, tone; poverty of speech, neologisms (making up words) difficulty with word finding, clanging (rhyming everything)
Term
factors for mood
Definition
how the patient feels

depressed < dysphoric < euthymic < elevated < euphoric

[image]
Term
factors for affect
Definition
how the patient displays that mood to the world

range:
full - showing emotion appropriately
restricted - not showing all emotion
blunted
flat - not showing any emotion at all; seen in schizophrenia

appropriate vs. not appropriate
Term
factors for sensorium
Definition
orientation (time, place, person, circumstance)
memory (especially recent)
calculations (serial 7 subtractions)
Term
factors for intelligence
Definition
current level of functioning
vocabulary
complexity of concept
Term
factors for thought
Definition
form (process)
content
abstracting ability
insight and judgment (poor, fair, good)
Term
abnormalities in thought form (process)
Definition
thought form is the expression of thoughts

goal-oriented (linear) thoughts are connected and presented in a logical manner

abnormalities:
circumstantial
tangential - goes off on tangents and may never answer the question (mania)
flight of ideas - going from one idea to the next very fast
loose associations - ideas are not connected (schizophrenia)
concrete thinking - what brought you to the hospital? a car (children, low IQ, schizophrenia)
thought blocking - lose the thought and is silent
Term
abnormalities in thought content
Definition
thought content is inner beliefs: what are you thinking about?

abnormalities:
delusion
suicidality
thought insertion - someone is inserting thoughts into their brain
thought broadcasting - ideas are being broadcasted out
ideas of reference - the TV is talking to me directly
hypersexuality
false perceptions - hallucinations
Term
role of dopamine (DA)
Definition
involved in Parkinson's disease, schizophrenia, depression, ADHD

involved in the reward system

primary receptor of interest:
D2 blockade - involuntary movements (extrapyramidal system); hyperprolactinemia (sexual dysfunction); decrease in positive symptoms
D2 activation - psychosis; antiparkinsonian effect; psychomotor activation; enhanced motivation and cognition
Term
role of norepinephrine (NE)
Definition
plays a role in depression, ADHD

2 primary receptors of interest: alpha1 and beta

alpha1:
activation - vasoconstriction, increased blood pressure
blockade - orthostatic hypotension (dizziness), reflex tachycardia, priapism

beta:
activation - increased heart rate, bronchial dilation, increased glucose, tremor
blockade - reduce heart rate, reduce tremor, bronchoconstriction, peripheral vasoconstriction
Term
role of serotonin
Definition
plays a role in depression, anxiety, eating disorders

receptors of interest:
5HT-1a - antagonism involved with anxiety
5HT-2a - antagonist cause decrease in negative symptoms
5HT-1d - blood flow (migraines)
5HT-2c - appetite (blockade = weight gain)
5HT-3 - antagonism = anti-nausea
Term
role of GABA
Definition
plays a role in anxiety, seizure activity

primary receptors of interest:
GABA-A - suppresses excess activity (seizures); alcohol, benzodiazepines, barbiturates act here
GABA-B - muscle relaxation; GHB, baclofen act here
Term
role of acetylcholine
Definition
blockage of muscarinic receptors = anticholinergic effects:

blurred vision
dry mouth
urinary retention
constipation
memory impairment
exacerbation of narrow angle glaucoma
sinus tachycardia
Term
role is histamine
Definition
several psychotropic medications possess antihistamine effects (diphenhydramine, quetiapine)

receptors of interest:
H1 - blockage = sedation, weight gain
H2 - blockage = reduces acidity in stomach
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