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Psych 110
Chapter 5 Research Methods
27
Psychology
Undergraduate 2
03/05/2013

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Term
Experimental Ablation
Definition
Removal or destruction of a portion of the brain of a lab animal
Term
RF Lesion
Definition
Brain lesion produced by passing radio frequency current through a wire in the brain
Term
Excitotoxic lesion
Definition
Lesion produced by an IC injection of an excitatory amino acid
Term
Selective Lesions
Definition
Can lesion particular groups of neurons with specific drugs
Term
Reversible lesions
Definition
Can use an anesthetic such as lidocaine to anesthetize part of the brain during a particular task
Term
Stereotaxic surgery
Definition
-Brain surgery using a stereotaxic apparatus to position an electrode or cannula in a specified position of the brain
Term
Stereotaxic apparatus
Definition
-Holds the animal’s head rigidly in a 3-D coordinate system
Term
Stereotaxic atlas
Definition
collection of drawings or sections of the brain with measurements that provide coordinates
Term
Computerized tomography (CT)
Definition
-The use of device that employs a computer to analyze data obtained by a scanning beam of X-rays to produce a 2-D picture
Term
Magnetic Resonance imaging (MRI)
Definition
technique used to image the interior of the body using the interaction between radio waves & a strong magnetic field
Term
Histological methods
Definition
-Need to verify placement of lesion, electrode, or cannula
-Used to fix, slice, sectioning, ande examine the brain
Term
Formalin
Definition
Aqueous solution of formaldehyde gas
Term
Micrtotome
Definition
Instrument used to produce very thin slices of tissue
Term
Sections
Definition
Slices of brain tissue
Term
Staining
Definition
- Used to see the fine details in the tissure
Term
Immunocytochemistry
Definition
-Localization of the receptor
-Localization of a peptide or protein
-Localization of synthesizing enzyme
Term
Autoradiography
Definition
-Localization of a radioactive ligand
Term
Anterograde labelling
Definition
-Labels cells bodies that give rise to terminal buttons that form synapses with cells in a particular region

1. Chemical taken up by terminal buttons
2. Tansported up to axon to the cell body
3. Use stain to reveal the chemical
Term
Retrograde labelling
Definition
-A recording of the electrical activity from a population of neurons
-Alpha waves: dominant during relaxation (eyes closed)
-Beta waves: dominant when awake & alert (eyes open)
Theta waves: seen in sleep (abnormal if seen in awake adults but normal in children up to 13yrs)
-Delta waves: dominant in stages 3 & 4 of sleep
Term
Microelectrode
Definition
-A fine electrode used to record activity of individual neurons
-Record while the animal is performing behavior
Term
Fos
Definition
-Nuclear protein produced during neural activation
Term
Positron emission tomography (PET)
Definition
Use of a device that reveals the location of a radioactive tracer in a living brain
Term
Functional MRi (fMRI)
Definition
Using MRI signal changes while people are performing tasks to assess areas that could be involved in that particular task performance.
Term
Targeted mutations
Definition
Genes that are mutated purposely to see how the animal behaves without it
Term
Twin studies
Definition
Method for examining the influence of heredity of a particular trait
Term
Fixative
Definition
Chemical used to prepare and preserve body tissue
Term
Electroencephalogram (EEG)
Definition
A recording of the electrical activity from a population of neurons

-Alpha waves: Dominant during relaxation
-Beta waves: Awake and alert
-Theta waves: Sleep
-Dleta waves- Dominant in stages 3 and 4 of sleep
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