Term
| What protein synthesis inhibitors act on the 30S ribosome? |
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Definition
| Tetracyclines, Glycylcyclines, Aminoglycosides |
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Term
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Definition
long half life. Can be either IV or PO Category B. Slightly broader than clarithro (except for H.Pylori)
covers strep pneumo, MSSA, lesser gram neg, atypicals, chlamydia. Used in practice for respiratory infections
SE - mainly GI distress
Resistance - altered target site, efflux pumps |
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Term
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Definition
this macrolide is only given PO. covers same as azithro, s. pneumo, MSSA, lesser gram neg, atypicals but NO chylamydia but gets H. Pylori
used in practice for respiratory infections
SE - mainly GI distress
Resistance - altered target site. efflux pump |
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Term
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Definition
additional binding site on the 50S ribosome. Similar to macrolides but ahd less resistance.
Se - visual changes (unique), QT prolongation, hepatotoxicity -> liver failure
stripped of its approval |
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Term
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Definition
IV and PO. Resistance same as macrolides (altered target side and efflux pump).
Typically used in pts with a penicillin allergy, CA-MRSA, cellulits, pneumonia
SE - most likely to cause C. dif diarrhea |
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Term
| name a member of the oxazolidinones |
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Definition
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Term
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Definition
used for MRSA and VRE
interferes with initiation (first step) at 50S ribosome
IV and PO. PO more common w/ 100% bioavailability. The first and only oral agent to treat HA-MRSA
No adjustments needed
SE - myelosuppresion as thrombocytopenia after 2 weeks. Monitor CBCs
DOC after switching from IV Dapto/Vanco |
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Term
| name the one streptogramin |
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Definition
| quinupristin and dalfopristin (synercid) |
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Term
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Definition
quinuprostin and dalfopristin
primarily a gram + agent. VRE (primary role), MRSA, and MSSA
IV only
take home: covers same as dapto and used for VRE |
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Term
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Definition
| tetracycline, doxycycline and minocycline |
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Term
what are tetracyclines used for?
MOA?
Side effects? |
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Definition
atypicals, and CA-MRSA, ricketsial infections (doxy), chlamydia (doxy)
binds 30S ribosome and prevents tRNA recognition
SE - deposition in calcified tissue, photosensitivity (not allergy), GI distress, |
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Term
| in a pt with poor kidney function, what tetracycline would you use? |
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Definition
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Term
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Definition
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Term
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Definition
broad spectrum. CA and HA MRSA, enterococcus, great gram neg (not pseudomonas)
works identical to tetracycline but overcomes reistance.
big downfall is only IV. No adjustment needed for renal dysfunction
used for intra-abdominal infxn and cSSSI |
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Term
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Definition
| all but obsolete. Very toxic. IV only. Gray baby syndrome and aplastic anemia |
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Term
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Definition
| gentamycin, tobramycin, amikacin |
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Term
| gentamycin, tobramycin and amakacin |
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Definition
IV only. covers lesser and greater gram neg and used in synergy against enterococcus. Always use with a beta-lactam unless a UTI
diffuse through porin channel via active transport. inhibits 30s
all eliminated renally. Monitor peaks and troughs
SE - nephrotoxicity, oto/neurotoxicity |
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