Term
|
Definition
Deposition of
amyloid in the
parenchyma of
the brain which is
toxic to neurons
and
oligodendroglia. |
|
|
Term
|
Definition
Death of cortical,
bulbar and
anterior cells
leads to gliosis
and
demyelination of
long tracts. |
|
|
Term
Basal ganglia
(Parkinson’s) |
|
Definition
Loss of
dopamine
producing cells
in the substantia
nigra |
|
|
Term
|
Definition
Effects the
dorsal root
ganglion
(cerebellar
neurons are
normal)
Exhibit
pyramidal signs. |
|
|
Term
|
Definition
Process of
demyelination of
tracts secondary
to inflammatory
process.
Inflammatory
process leads to
plaque formation
that interferes
with impulse
conduction. |
|
|
Term
|
Definition
Purkinje cells in
cerebellum
degenerate.
Cerebellar nuclei
generally
unaffected. |
|
|
Term
|
Definition
Giant m motor
units have high
metabolic
demand. Over
years of use
(overuse) these
undergo
"premature
exhaustion".
(Fredricks and |
|
|
Term
|
Definition
Asymmetric
weakness, usually
distal at first.
Muscle cramps &
fasciculations Spasticity,
hyperreflexia & +
Babinski
Dysphagia.
Usually do NOT
have bowel and
bladder problems,
or problems with
eye movements |
|
|
Term
|
Definition
Bradykinesia
Resting tremor
Rigidity
Postural
instability Micrographia
Bradyphrenia |
|
|
Term
|
Definition
Ataxia of all 4
limbs, cerebellar
dysarthria,
sensory loss,
absent LE reflexes |
|
|
Term
|
Definition
Visual
disturbance
Paresthesia
Weakness
Ataxia urinary problems |
|
|
Term
|
Definition
Falls,
unsteadiness.
For the pts we
saw vision might
be the first noted problem |
|
|
Term
|
Definition
Muscle
weakness from previously weak ms. Extreme fatigue
Joint and muscle
pain
Cold intolerance
Sleep apnea
Respiratory
difficulties in
patient
previously
ventilated
Dysphagia in
patient who
previously had
bulbar polio.
Progressive
deformities due
to mm
imbalance
Deteriorating
gait |
|
|
Term
|
Definition
exacerbation of
symptoms,
followed by a
period where the
symptoms remit
followed by a
long period
where no new
symptoms
appear. Over
time the patient
gradually
accumulates
some deficits as
a result of each
exacerbation
and worsens. |
|
|
Term
|
Definition
continues to
worsen type of ms |
|
|
Term
|
Definition
patient
has some
symptoms that
remit and is
essentially
disease free
between
exacerbations. type of ms |
|
|
Term
|
Definition
| these pts typically develop cardiac myopathy |
|
|
Term
|
Definition
neuromuscular effects of disease?
Loss of muscle
bulk, possibly
associated with
changes in
metabolism |
|
|
Term
|
Definition
neuroms effects of disease?
Combination of
flaccid and
spastic paralysis
together with
bulbar paralysis
Fasciculations |
|
|
Term
|
Definition
Neuro MS effects of disease?
Rigidity
Pts generally
are not weak
although some
weaknesses
have been
shown later in
the disease. |
|
|
Term
|
Definition
neuroms effects of disease?
Progressive
weakness and
ataxia. |
|
|
Term
|
Definition
Neuro MS effects of disease?
Muscle
weakness,
spasticity, ataxia
and spasms,
depending on
the site of the
plaques. |
|
|
Term
|
Definition
neuro ms effects of disease?
Minimal effects
on strength.
Problem lies in
the scaling of
force and timing
of motor unit
firing. |
|
|
Term
|
Definition
neuro ms effect of disease?
Loss of strength
in muscle
previously
affected by polio
and some mm
previously
unaffected. |
|
|
Term
|
Definition
| glossopharyngeal nerve (IX), vagus nerve (X), and hypoglossal nerve (XII) |
|
|
