Term
| HOW DOES ANTIFIBRINOLYTICS AND INHIBITORS OF ANTICOAGULATION WORK? |
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Definition
| DECREASE PLASMINOGEN ACTIVATION AND PLASMIN ACTIVITY (KEEPS THINGS FROM BREAKING DOWN CLOTS; DOESN'T CAUSE CLOTS). THEY ARE USED TO DECREASE BLOOD LOSS IN THE PERIOPERATIVE PERIOD. |
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Term
| WHAT ARE 5 SIDE EFFECTS OF ANTIFIBRINOLYTICS AND INHIBITORS OF ANTICOAGULATION? |
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Definition
| HYPOTENSION, BRADYCARDIA, ARRHYTHMIAS, THRMOBOSIS, THROMBOCYTOPENIA |
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Term
| WHAT KIND OF SIDE EFFECTS CAN APROTININ CAUSE? |
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Definition
| MAY CAUSE ANAPHYLAXIS AND RENAL FAILURE |
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Term
| WHAT IS THE DOSE OF TRANEXAMIC ACID (CYKLOKAPRON, LYSTEDA)? |
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Definition
| 1GM/100ML OVER AT LEASE 10 MINUTES (FASTER INFUSION MAY CAUSE HYPOTENSION). |
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Term
| WHERE IS TRANEXAMIC ACID (CYKLOKAPRON, LYSTEDA) EXCRETED AT? |
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Definition
| RENAL (USE CAUTION IN RF PT'S) |
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Term
| WHAT IS THE DOSE AND EXCRETION OF AMINOCAPROIC ACID (AMICAR)? |
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Definition
| 5GM/100-250ML OF NS OVER 15-30 MINUTES EXCRETED RENALLY |
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Term
| IS VITAMIN K A FAT OR WATER SOLUBLE VITAMIN? |
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Definition
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Term
| WHERE IS VITAMIN K MOSTLY FOUND IN AND WHAT IS IT SYNTHESIZED BY? |
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Definition
| GREEN LEAFY VEGETABLES AND SYNTHESIZED BY INTESTINAL BACTERIA |
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Term
| WHAT IS THE MOA OF VITMAIN K? |
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Definition
| HELPS LIVER SYNTHESIZE FACTORS II, VII, IX, AND X (VITAMIN K DEPENDENT FACTORS) |
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Term
| WHAT IS THE IM OR SC DOSE OF VITAMIN K? |
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Definition
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Term
| WHAT IS THE IV DOSE OF VITAMIN K? |
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Definition
| 1-10MG IV SLOWLY START AT LOWER END, ESP IN PTS WITH PROSTHETIC VALVES |
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Term
| WHAT IS THE ONSET AND DURATION OF VITAMIN K? |
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Definition
| 6 HRS AND DURATION OF 24 HRS |
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Term
| WHAT ARE 4 SIDE EFFECTS OF VITAMIN K? |
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Definition
| DYSPNEA, CHEST PAIN, ANAPHYLAXIS, THROMBOEMBOLISM |
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Term
| IS SEVERE HEPATIC DISEASE UNRESPONSIVE TO VIT K THERAPY? |
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Definition
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Term
| DESMOPRESSIN (DDAVP) IS A SYNTHETIC POLYPEPTIDE THAT IS STRUCTURALLY SIMILAR TO WHAT? |
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Definition
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Term
| WHAT 2 RECEPTORS DOES DESMOPRESSIN WORK ON? |
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Definition
| V1 RECEPTORS (VSM CONSTRICTION) VS V2 RECEPTORS (ADH). |
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Term
| WHAT ARE 6 INDICATIONS FOR THE USE OF DESMOPRESSIN? |
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Definition
| HEMOPHILIA, VON WILLEBRAND'S DISEASE, UREMIC BLEEDING (FROM EXTREMELY ELEVATED BUN), ANTIPLT DRUG REVERSAL, PLT DYSFUNCTION AFTER SURGERY, CENTRAL DIABETES INSIPIDUS. |
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Term
| IS THE MOA OF DESMOPRESSIN THROUGH THE INTRINSIC OR EXTRINSIC PATHWAY? |
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Definition
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Term
| HOW DOES DESMOPRESSIN WORK IN THE EXTRINSIC PATHWAY? |
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Definition
| DOSE DEPENDENT INCREASE IN FACTOR VIII, PLASMINOGEN ACTIVATOR, AND VWF. VWF CAUSES PLT ADHESION AND AGGREGATION. VIII HELPS ACTIVATE REST OF DOWNSTREAM COAGULATION CASCADE. IN THE KIDNEYS THERE IS INCREASE WATER REABSORPTION/RETENTION |
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Term
| WHAT IS THE INTRANASAL DOSE OF DESMOPRESSIN? |
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Definition
| 300MCG 2 HRS PRIOR TO SURGERY |
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Term
| WHAT IS THE IV/SC DOSE OF DESMOPRESSIN? WHEN SHOULD IT BE GIVEN? |
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Definition
| 0.3-0.5MCG/KG INFUSED OVER 30 MINUTES (GIVE 1 HR BEFORE SURGERY) |
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Term
| WHAT IS THE INTRANASAL AND IV ONSET OF DESMOPRESSIN? |
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Definition
| INTRANASAL IS 30-90 MINUTES. IV IS 30 MINUTES (PEAKS BETWEEN 1.5-2 HRS). |
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Term
| WHAT IS THE DURATION, METABOLISM, AND EXCRETION OF DESMOPRESSIN? |
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Definition
| DURATION IS 3 HRS, METABOLISM IS UNKNOWN, AND EXCRETION IS RENALLY |
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Term
| WHAT ARE 8 SIDE EFFECTS OF DESMOPRESSIN? |
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Definition
| WATER RETENTION, HYPONATREMIA (DILUTIONAL), FLUSHING, HYPERTENSION (VA RECEPTOR RESPONSE), HYPOTENSION (WITH TACHY R/T PROSTAGLANDIN RELEASE), TACHYCARDIA, THROMBOCYTOPENIA, TACHYPHYLAXIS (TYPICAL IF MORE THAN ONE DOSE PER 48 HRS). THE HYPO OR HYPER TENSION IS DEPENDENT ON HOW SENSITIVE PT IS TO DILATION AND CONSTRICTION. |
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Term
| RECOMBINANT FACTOR VIIA IS USED FOR WHAT? |
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Definition
| TREATMENT OF BLEEDING IN HEMOPHILIACS. DIFFICULT TO GET BUT BIGGER PROBLEM IS COST! VERY EXPENSIVE, BUT EFFECTIVE |
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Term
| HOW DOES RECOMBINANT FACTOR VIIA WORK? |
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Definition
| ACTIVATES FACTOR X WHICH GREATLY INCREASES THROMBIN ACTIVITY AND CONVERTS FIBRINOGEN TO FIBRIN. |
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Term
| WHAT IS THE DOSE OF RECOMBIANT FACTOR VIIA? |
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Definition
| DOSE IS 50-100MCG IV EVERY 2 HRS |
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Term
| WHAT IS THE MAIN SIDE EFFECT WITH RECOMBINANT FACTOR VIIA? |
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Definition
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Term
| THE EFFECTS OF RECOMBINANT FACTOR VIIA CAN BE BLOCKED BY WHAT 2 MECHANISMS? |
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Definition
| ACIDOSIS AND HYPOTHERMIA. PH OF AT LEAST 7.2 OR GREATER AND TEMP AT LEAST 33 DEGREES C = 91.4 F |
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Term
| HAS RECOMBINANT FACTOR VIIA BEEN USED FOR REVERSAL OF COUMAIN? |
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Definition
| YES, IN LOWER DOSES (20MCG/KG OR 1.2 MG IV) |
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Term
| FACTOR VIII AND IX CAN BE CONCENTRATED FROM WHERE? |
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Definition
| POOLED PLASMA. SO HEPATITIS TRANSMISSION IS A RISK. RECOMBINANT FACTORS ARE PREFERRED IF AVAILABLE. |
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Term
| WHAT IS THE INITITAL LOASING DOSE FOR FACTOR VIII AND IX? |
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Definition
| FOR FACTOR VIII IS 50 UNITS/KG. REDOSE EVERY 12 HRS BASED ON CLINICAL PRESENTATION. |
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Term
| WHAT IS THE DOSE FOR FACTOR IX? |
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Definition
| 25-100U UNITS/KG LASTS 24 HRS |
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Term
| WHAT DOES PROTHROMBIN COMPLEX CONCENTRATE CONTAIN? |
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Definition
| ALL VITAMIN-K DEPENDENT FACTORS. SOME SOURCES USE THIS TERM FOR FACTOR 9 COMPLEX. |
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