Term
| What does BSE cause in Cows? If ingested? |
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Definition
Cow= Mad Cow Disease
Humans= vCJD |
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Term
| Do Prions contain nucleic acids? |
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Definition
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Term
| What do most Prion diseases cause? |
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Definition
| Spongiform encephalopathies |
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Term
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Definition
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Term
| In what 3 diseases do patients have PrPc mutations? |
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Definition
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Term
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Definition
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Term
| What is CJD misdiagnosed as usually? |
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Definition
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Term
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Definition
| FFI (Fatal Familial Insomnia) |
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Term
| What 2 mutations do you need for CJD and FFI? (Common and unique) |
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Definition
Both need a mutation from Asp-->ASN at 178.
Mutation to Val at 129= CJD
Mutation to Met at 129= FFI |
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Term
| Buzzword: Eating/working with cows in England. |
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Definition
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Term
| If you see formed Plaques in sample it could be what 2 diseases? |
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Definition
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Term
| If you see Spongiform Vacuoles in sample what could it be? |
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Definition
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Term
| PrPc is normally found where? |
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Definition
| Membrane surface on neurons in brain |
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Term
| PrPSc are normally found where? |
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Definition
| Intracellular (once PrPSc's come together, neuron takes them up and stores them in vacuoles) |
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