Term
| you can have something that will only be toxic to the thing you want to kill and spare everything else in the body (ex: arsenic derivatives for syphilis) |
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Definition
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Term
| not exclusive and not specific; these substances are more toxic to whatever cells you are aiming to kill, but not toxic to those alone |
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Definition
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Term
| specific to experimental conditions, practical utility in clinical toxicology controversial; dose required to kill 50% of population |
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Definition
| median lethal dose (LD50) |
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Term
| taking a large dose of barbiturates on its own versus taking it with alcohol --> interactions! |
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Definition
| Concurrent exposure to other toxins |
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Term
| its not the amount that matters but that you administer locally-- inhaled or IV it is one of the most toxic things on earth |
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Definition
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Term
| very toxic; if you administer it on a mucous membrane it causes respiratory arrest |
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Definition
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Term
| systemically or IV at a very low dose can cause 50% of a mouse population to be killed. If you give it orally the LD50 is 10g/kg, It is 1000 times less toxic orally than IV. |
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Definition
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Term
| Generally, antibacterial, not necessarily naturally derived |
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Definition
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Term
| end point is probabilistic; applies to all sorts of cytotoxic insults |
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Definition
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Term
| use maximal tolerable doses, high-dose intermittent pulses, polypharmacy |
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Definition
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Term
| attack the same site, one is displacing the other therefore only experiencing benefit from one that binds better |
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Definition
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Term
| attacks two physically distinct points on a pathway-- combo better than sum of parts |
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Definition
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Term
| cells are sensitive to these agents when they are in a metabolic state (when they are rapidly growing) |
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Definition
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Term
| these agents stop or greatly inhibit metabolism |
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Definition
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Term
| Mixed and matched for tuberculosis therapy |
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Definition
| "cidal" and "static" agents |
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